4.5 Article

Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cytoplasmic localization of Mdm2 in cells expressing mutated NPM is mediated by p53

Dita Strachotova et al.

Summary: Specific C-terminal nucleophosmin (NPM) mutations are associated with acute myeloid leukaemia and cause mislocalization of NPMmut to the cytoplasm. This leads to mislocalization of NPM-interacting partners, including the tumor suppressor p53. We discovered the formation of a ternary complex consisting of NPMmut, p53, and Mdm2, with p53 acting as a bridging link between Mdm2 and NPMmut. Silencing of p53 prevented mislocalization of Mdm2 in the presence of NPMmut.

FEBS JOURNAL (2023)

Article Biochemistry & Molecular Biology

Small molecules enhancers of amyloid aggregation of C-terminal domain of Nucleophosmin 1 in acute myeloid leukemia

Daniele Florio et al.

Summary: The NPM1 mutations in Acute Myeloid Leukemia have been found to affect the nucleolus, and the use of small molecules to enhance amyloid aggregation may provide a novel therapeutic approach for AML progression.

BIOORGANIC CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation

Binsah George et al.

Summary: Mutations in the tumor suppressor gene TP53 are strongly linked to poor survival outcomes in AML patients, particularly in cases with complex cytogenetics or therapy-related AML. Despite the prevalence of TP53 mutations in cancer, targeted therapeutic interventions for these mutations remain limited, highlighting the need for personalized treatment strategies. Understanding the functional differences of p53 mutants is crucial in developing effective therapies for AML patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization

Marketa Sasinkova et al.

Summary: Nucleophosmin mutations causing export from the nucleoli to the cytoplasm are common in AML, leading to altered functions. NSC348884 was studied as a potential inhibitor of NPM oligomerization, but was found to not inhibit oligomer formation, with cytotoxicity instead linked to cell adhesion signaling.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Multidisciplinary

Chemotherapy-Induced Survivin Regulation in Acute Myeloid Leukemia Cells

Petra Otevrelova et al.

Summary: The study identified enhanced survivin expression in AML cells treated with Ara-C, which caused growth arrest and depletion of the mitotic cell fraction. Further investigation revealed that idarubicin reversed Ara-C-induced survivin upregulation in most AML cell lines, while YM-155 caused survivin deregulation and decreased viability in cells resistant to idarubicin treatment. The study also showed considerable changes in the expression levels of other apoptosis-related proteins and the cell-cycle inhibitor p21, indicating off-target effects of YM-155.

APPLIED SCIENCES-BASEL (2021)

Article Cell Biology

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

Lilian C. Russo et al.

Summary: DUSP3 interacts with NPM in the cell nucleus after UV stress, showing high-affinity binding and dephosphorylating specific tyrosines of NPM. This interaction affects HDM2-p53 interaction in the nucleoplasm, leading to increased stability and transcriptional activity of p53, favoring DNA repair and genomic stability.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

AML-Related NPM Mutations Drive p53 Delocalization into the Cytoplasm with Possible Impact on p53-Dependent Stress Response

Ales Holoubek et al.

Summary: The study aims to explore the interaction between NPM and p53, the effect of NPM mutations on p53 in live cells, and the cellular dynamics of NPMmut and p53 after treatment with Selinexor. Results showed that NPM mutations do not affect their interaction with p53, and expression of NPMmut in cells leads to altered p53 regulation and nuclear relocalization post Selinexor treatment, providing new insights for investigating these mutations.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Nucleophosmin in leukemia: Consequences of anchor loss

Barbora Brodska et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

Article Cell Biology

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

Johannes Ristau et al.

CELL DEATH & DISEASE (2019)

Article Biochemistry & Molecular Biology

AML-associated mutation of nucleophosmin compromises its interaction with nucleolin

Marketa Sasinkova et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Low-Dose Actinomycin-D Induces Redistribution of Wild-Type and Mutated Nucleophosmin Followed by Cell Death in Leukemic Cells

Barbora Brodska et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair

Daniel D. Scott et al.

BIOCHEMISTRY AND CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

Yuuki Kozakai et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

The roles of nucleolin subcellular localization in cancer

Caroline Madeleine Berger et al.

BIOCHIMIE (2015)

Article Multidisciplinary Sciences

The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

Hui-Ching Chuang et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Structural polymorphism in the N-terminal oligomerization domain of NPM1

Diana M. Mitrea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

Induction and activation of the p53 pathway: a role for the protein kinase CK2?

David W. Meek et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells

Arsene M. Adon et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest

Luciana E. Giono et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Review Oncology

Nucleophosmin and cancer

Silvia Grisendi et al.

NATURE REVIEWS CANCER (2006)

Article Biochemistry & Molecular Biology

Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing

P Tarapore et al.

FEBS LETTERS (2006)

Letter Biochemistry & Molecular Biology

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

M Krajewski et al.

NATURE MEDICINE (2005)

Article Biochemistry & Molecular Biology

Nucleophosmin is required for DNA integrity and p19Arf protein stability

E Colombo et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Medicine, General & Internal

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

B Falini et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Biochemistry & Molecular Biology

B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1

H Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors

N Issaeva et al.

NATURE MEDICINE (2004)

Review Biochemistry & Molecular Biology

Decision making by p53: life, death and cancer

M Oren

CELL DEATH AND DIFFERENTIATION (2003)

Article Biochemistry & Molecular Biology

Role of protein kinase CK2 phosphorylation in the molecular chaperone activity of nucleolar protein B23

A Szebeni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation

Y Daniely et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Cell Biology

Nucleophosmin regulates the stability and transcriptional activity of p53

E Colombo et al.

NATURE CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Specific phosphorylation of nucleophosmin on Thr199 by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication

Y Tokuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)