4.7 Article

A modular zinc finger adaptor accelerates the covalent linkage of proteins at specific locations on DNA nanoscaffolds

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 6, Pages 1016-1019

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08167f

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan [24651150, 25248038]
  2. Grants-in-Aid for Scientific Research [25248038, 24651150] Funding Source: KAKEN

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A modular adaptor consisting of a sequence-specific DNA binding zinc finger protein and a self-ligating protein-tag was developed to expedite efficient formation of a covalent linkage between an individual protein molecule and the programmed address modified with a tag-substrate on the DNA nanostructure.

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