The E3 ubiquitin ligase MIB1 suppresses breast cancer cell migration through regulating CTNND1 protein level

Breast cancer is one of the most common invasive cancers among women. The leading cause of difficulty in treating breast cancer patients is metastasis. Because cell migration is closely related to breast cancer metastasis, elucidating the detailed mechanism by which breast cancer cells promote their migration is crucial for improving the prognosis of patients. In this study, we investigated the relationship between breast cancer cell migration and Mind bomb1 (MIB1), an E3 ubiquitin ligase. We found that the downregulation of MIB1 promotes the cell migration of MCF7, a breast cancer-derived cell line. Furthermore, knockdown of MIB1 caused a reduction in CTNND1 and thereby impaired E-cadherin membrane localization in the cell boundary region. Taken together, our data suggest that MIB1 might play a role in suppressing breast cancer cell migration.(c) 2023 Elsevier Inc. All rights reserved.

Automated summary

Breast cancer, a common and invasive cancer among women, is often difficult to treat due to metastasis. This study reveals the relationship between breast cancer cell migration and the E3 ubiquitin ligase Mind bomb1 (MIB1). The downregulation of MIB1 promotes cell migration and impairs E-cadherin membrane localization in breast cancer cells, suggesting a potential role of MIB1 in suppressing breast cancer metastasis.