Journal
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/bcpt.13945
Keywords
chlorpyrifos; inflammatory cytokine; lactobacillus; organophosphates; oxidative stress
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Chlorpyrifos has potential toxic effects on non-target organisms. Lactic acid bacteria, through their antioxidant and anti-inflammatory activity, can mitigate the tissue damage induced by chlorpyrifos. The levels of TNF-alpha in the kidneys and testicles were altered by chlorpyrifos exposure, and probiotic treatment restored these levels.
Chlorpyrifos (CPF) has caused many potential toxicities in nontarget organisms. Fewer studies have been conducted on the effects of lactic acid bacteria (LAB) in mitigating tissue damage induced by CPF in vivo. Therefore, we investigated CPF renal and testicular toxicity and the alleviating effect of probiotic lactobacilli, based on antioxidant and anti-inflammatory activity, on induced toxicity in an animal model. Biochemical assays showed that CPF induced oxidative stress along with a change in superoxide dismutase (SOD) and catalase (CAT) activity in a tissue-dependent manner. After treatment with CPF, testicular and renal levels of TNF-alpha were significantly reduced and enhanced, respectively, compared to the control group. The probiotic treatment restored renal and testicular TNF-alpha levels and modulated and blocked the increasing effect of CPF on renal IL-1 beta levels. Testicular IL-1 beta levels in the probiotic-treated and CPF groups demonstrated similar values. Exposure to CPF significantly induced renal histopathological damage that, of course, was completely inhibited by treatment with Lactobacillus casei and the LAB mixture. In summary, CPF showed significant toxicological effects on oxidative stress and the inflammation rate in CPF-exposed rats. Therefore, supplementation with probiotic bacteria may alleviate CPF renal toxicity and mitigate its oxidative stress and inflammation effects.
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