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Article
Multidisciplinary Sciences
Unique amphipathic helix drives membrane insertion and enzymatic activity of ATG3
Taki Nishimura et al.
Summary: Autophagosome biogenesis relies on lipid membrane dynamics and a specific protein-lipid conjugate. The molecular mechanisms of this process, especially the final step of ATG8/LC3 lipidation, have been elucidated. The AH(ATG3) in ATG3 proteins regulates the dynamics and accessibility of the thioester bond, enabling the covalent lipidation of LC3. The unique properties of AH(ATG3) facilitate protein-lipid bilayer association, leading to the remodeling of the lipid bilayer required for autophagosome formation.
SCIENCE ADVANCES (2023)
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