4.8 Article

ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1

Related references

Note: Only part of the references are listed.
Article Cell Biology

Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer

Lin Zhong et al.

Summary: This study found that autophagy-related gene 4B (ATG4B) was overexpressed in advanced gastric cancer (GCa) tumors and was associated with poor prognosis. Researchers identified Azalomycin F4a (Am-F4a) as a potent ATG4B inhibitor through screening a natural compound library. Am-F4a effectively inhibited GCa cell autophagy by directly binding to and inhibiting ATG4B, leading to suppressed tumor growth and reduced cell migration and invasion. Additionally, Am-F4a sensitized tumors to chemotherapy.

CELL DEATH & DISEASE (2022)

Article Biochemistry & Molecular Biology

Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense

Weihong Xie et al.

Summary: Our study identifies E3 ubiquitin ligase NEDD4 as a negative regulator of type I interferon signaling by targeting TBK1 for degradation at the late stage of viral infection. Mechanistically, NEDD4 catalyzes the K27-linked poly-ubiquitination of TBK1 at K344, providing a recognition signal for NDP52-mediated selective autophagic degradation. This reveals the regulatory role of NEDD4 in balancing TBK1-centered type I IFN activation and provides insights into the crosstalk between selective autophagy and antiviral signaling.

CELL DEATH AND DIFFERENTIATION (2022)

Review Biochemistry & Molecular Biology

Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities

Manzar Alam et al.

Summary: TBK1 plays a fundamental role in regulating cellular responses and controlling signaling cascades. Dysregulation of the TBK1 pathway is associated with various pathophysiological conditions. Inhibitors targeting TBK1 have potential therapeutic applications for diseases, including cancer.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Multidisciplinary Sciences

Deacetylation of ATG4B promotes autophagy initiation under starvation

Liangbo Sun et al.

Summary: This study reveals an acetylation-dependent regulatory mechanism that controls the role of ATG4B in autophagy initiation in response to nutritional deficiency. It was demonstrated that the deacetylation of ATG4B at K39 by SIRT2 activates ATG4B during starvation, leading to enhanced interaction with pro-LC3 and promotion of LC3-II formation.

SCIENCE ADVANCES (2022)

Article Cell Biology

USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy

Xibao Zhao et al.

Summary: Research has shown that USP19 plays a crucial role in promoting TBK1 lysosomal degradation through chaperone-mediated autophagy, contributing to immune response and infectious diseases. This study uncovers a novel role for USP19 in CMA-mediated TBK1 degradation.

AUTOPHAGY (2022)

Review Chemistry, Medicinal

Targeting Atg4B for cancer therapy: Chemical mediators

Gaoxia Yang et al.

Summary: Atg4B is a pivotal protein family in macroautophagy/autophagy that regulates the autophagy process and plays a key role in the development of human cancers. Efforts are being made to explore Atg4B inhibitors or activators for the development of novel drugs targeting Atg4B for potential clinical applications.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Medicine, Research & Experimental

Prevention and treatment of COVID-19: Focus on interferons, chloroquine/hydroxychloroquine, azithromycin, and vaccine

Bianza Moise Bakadia et al.

Summary: The ongoing COVID-19 pandemic has spurred discussions on various treatment and prevention methods, with some showing potential effects but also facing controversies. The focus is on finding effective solutions for sustainable pandemic control.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Immunology

Autophagy in inflammation, infection, and immunometabolism

Vojo Deretic

Summary: Autophagy is a crucial cellular protection mechanism that impacts various diseases when disrupted, including infections, autoimmune diseases, and cancer. It plays a role in clearing harmful substances in and out of cells, protecting against inflammatory damage. The article focuses on the role of autophagy in inflammation, as well as its intersections with immunity, metabolism, and organelle functions.

IMMUNITY (2021)

Review Biochemistry & Molecular Biology

Selective Autophagy Receptors in Antiviral Defense

Christophe Viret et al.

Summary: Autophagy is crucial for degrading cellular substrates and defending against viruses; autophagy receptors interact with viral cargoes to facilitate the elongation of autophagic membranes and promote host cell responses to virus infection.

TRENDS IN MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity

Martina Wirth et al.

Summary: Autophagy is a crucial degradative pathway for maintaining cellular homeostasis, with ATG8 proteins playing a central role in autophagosome formation and cytoplasmic cargo delivery. The binding specificity of ATG8 proteins with autophagy adaptors and receptors involves LIR motifs and phosphorylation. This study reveals the binding of a LIR motif in the Golgi protein SCOC to GABARAP, GABARAPL1, LC3A and LC3C, with phosphorylation regulating the affinity of LC3 family binding.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Review Cell Biology

The interplay of autophagy and enterovirus

Lihong Huang et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease

Lina Herhaus et al.

EMBO REPORTS (2020)

Review Immunology

RIG-I-like receptors: their regulation and roles in RNA sensing

Jan Rehwinkel et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Immunology

Double-Stranded RNA Sensors and Modulators in Innate Immunity

Sun Hur

Annual Review of Immunology (2019)

Editorial Material Cell Biology

Antiviral immunity: a link to bile acids

Jing Wang et al.

CELL RESEARCH (2019)

Article Cell Biology

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

Suresh Kumar et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

Jose Norberto S. Vargas et al.

MOLECULAR CELL (2019)

Review Cell Biology

Modulation of Autophagy for Controlling Immunity

Young Jin Jang et al.

CELLS (2019)

Review Pharmacology & Pharmacy

TANK-binding kinase 1 as a novel therapeutic target for viral diseases

Chunyuan Zhao et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

Review Immunology

RIG-I and Other RNA Sensors in Antiviral Immunity

Kwan T. Chow et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

Review Cell Biology

Autophagy balances inflammation in innate immunity

Vojo Deretic et al.

AUTOPHAGY (2018)

Review Microbiology

Autophagy during viral infection - a double-edged sword

Younho Choi et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemistry & Molecular Biology

Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway

Robert Weil et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

Article Biochemistry & Molecular Biology

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1

Shouheng Jin et al.

EMBO JOURNAL (2016)

Article Multidisciplinary Sciences

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Benjamin Richter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity

Vera V. Saul et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates

Min Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

The autophagy machinery is required to initiate hepatitis C virus replication

Marlene Dreux et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Virology

Modification of cellular autophagy protein LC3 by poliovirus

Matthew P. Taylor et al.

JOURNAL OF VIROLOGY (2007)

Article Biochemistry & Molecular Biology

Subversion of cellular autophagosomal machinery by RNA viruses

WT Jackson et al.

PLOS BIOLOGY (2005)

Review Cell Biology

Organization of vesicular trafficking in epithelia

E Rodriguez-Boulan et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Multidisciplinary Sciences

A ubiquitin-like system mediates protein lipidation

Y Ichimura et al.

NATURE (2000)