Journal
AUTOPHAGY
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2023.2247300
Keywords
AMPK; autophagy; carbon starvation; energy metabolism; glucose starvation; Snf1; >
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Macroautophagy/autophagy plays a crucial role in cell survival and maintaining cellular energy homeostasis during starvation or energy stress. Further investigation is needed to understand the specific substrates degraded by autophagy during glucose or energy deprivation and the diverse roles and mechanisms during varying durations of energy starvation.
Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival and maintaining cellular energy homeostasis during starvation or energy stress. Its regulation is intricately linked to cellular energy status. In this review, covering yeast, mammals, and plants, we aim to provide a comprehensive overview of the understanding of the roles and mechanisms of carbon- or glucose-deprivation related autophagy, showing how cells effectively respond to such challenges for survival. Further investigation is needed to determine the specific degraded substrates by autophagy during glucose or energy deprivation and the diverse roles and mechanisms during varying durations of energy starvation.
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