4.6 Article

Residual pain in rheumatoid arthritis: Is it a real problem?

Related references

Note: Only part of the references are listed.
Review Rheumatology

Non-inflammatory pain in inflammatory arthritis

Dhivya Das et al.

Summary: Non-inflammatory pain is common in patients with inflammatory arthritis, and one important cause is concomitant fibromyalgia. Fibromyalgia is common in RA patients, affecting 1 in 5 patients, and is associated with higher disease activity scores. European Alliance of Association for Rheumatology highlights that concomitant fibromyalgia is an important consideration in assessing difficult-to-treat RA.

RHEUMATOLOGY (2023)

Article Rheumatology

Disproportionate articular pain is a frequent phenomenon in rheumatoid arthritis and responds to treatment with sarilumab

Ernest Choy et al.

Summary: This study assessed the effects of IL-6 inhibitor sarilumab on disproportionate articular pain (DP) in patients with rheumatoid arthritis (RA). The results showed that about one-quarter of RA patients experienced DP and sarilumab treatment had a positive effect on DP.

RHEUMATOLOGY (2023)

Review Rheumatology

The Biology of Pain: Through the Rheumatology Lens

Flavia Sunzini et al.

Summary: Chronic pain, especially musculoskeletal pain, is a significant burden on society. In diseases such as rheumatoid arthritis (RA), chronic pain greatly impacts quality of life. Peripheral inflammation plays a crucial role in nociceptive pain, but the coexistence of different pain states suggests the involvement of other mechanisms, such as nociplastic pain. This review focuses on the biology of pain, specifically nociplastic pain in RA.

ARTHRITIS & RHEUMATOLOGY (2023)

Review Rheumatology

Fibromyalgia and centralized pain in the rheumatoid arthritis patient

Deeba Minhas et al.

Summary: This review highlights the frequent coexistence of fibromyalgia and augmented central nervous system processing in individuals with rheumatoid arthritis (RA), which may contribute to persistent pain. IL-6 and Janus kinase inhibitors, in addition to targeting peripheral inflammation, may provide pain relief by acting on both peripheral and central pain pathways.

CURRENT OPINION IN RHEUMATOLOGY (2023)

Article Rheumatology

Early characterization of difficult-to-treat rheumatoid arthritis by suboptimal initial management: a multicentre cohort study

Alessandro Giollo et al.

Summary: The failure to optimize treatment in early rheumatoid arthritis (RA) is associated with difficult-to-treat RA (D2T-RA). Treatment delay beyond 3 months and non-discontinuation of glucocorticoids after 6 months are early predictive features of D2T-RA.

RHEUMATOLOGY (2023)

Review Rheumatology

Points to consider for cost-effective use of biological and targeted synthetic DMARDs in inflammatory rheumatic diseases: results from an umbrella review and international Delphi study

Celeste J. T. van der Togt et al.

Summary: The objective of this study was to develop evidence-based points to consider for cost-effective use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in the treatment of inflammatory rheumatic diseases.

RMD OPEN (2023)

Article Rheumatology

EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis

Gyorgy Nagy et al.

Summary: The EULAR Task Force developed evidence-based points to consider for the management of difficult-to-treat rheumatoid arthritis, covering diagnostic confirmation, evaluation of inflammatory disease activity, pharmacological and non-pharmacological interventions, treatment adherence, functional disability, pain, fatigue, goal setting, self-efficacy, and impact of comorbidities. The strength of recommendations varied from level C to D, with a generally high level of agreement.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Review Immunology

Methotrexate in early rheumatoid arthritis: Is the anchor drug still holding?

Alessandro Giollo et al.

Summary: Treat-to-target is the most fashionable strategy for early rheumatoid arthritis patients. Methotrexate combined with glucocorticoid bridging is the main approach, but it is often used suboptimally. Recent studies have shown that novel targeted synthetic DMARDs, such as JAK inhibitors, in combination with glucocorticoids, have better outcomes in early RA patients, but safety concerns remain.

AUTOIMMUNITY REVIEWS (2022)

Article Rheumatology

Treat-to-target in rheumatoid arthritis: a real-world study of the application and impact of treat-to-target within the wider context of patient management, patient centricity and advanced therapy use in Europe

Peter C. Taylor et al.

Summary: Despite recommendations, the treat-to-target (T2T) approach for rheumatoid arthritis (RA) appears to be suboptimally implemented in clinical practice. Only about two-thirds of patients were reported to be managed using a T2T approach by their rheumatologists, and there was inconsistency between patients and physicians in setting treatment goals.

RMD OPEN (2022)

Review Medicine, General & Internal

Difficult-to-treat rheumatoid arthritis: Current concept and unsolved problems

Ryu Watanabe et al.

Summary: Difficult-to-treat rheumatoid arthritis (D2T RA) is a complex disease state characterized by uncontrolled disease activity, decreased quality of life, and high healthcare utilization. The mechanisms underlying D2T RA and the factors contributing to its difficult-to-treat state are not fully understood, and may vary among patients, sex, country, and race. This article discusses the definition, prevalence, management and therapeutic strategies for D2T RA, as well as a clinical approach to prevent the development of D2T RA.

FRONTIERS IN MEDICINE (2022)

Article Rheumatology

Remission or Not Remission, That's the Question: Shedding Light on Remission and the Impact of Objective and Subjective Measures Reflecting Disease Activity in Rheumatoid Arthritis

Alen Brkic et al.

Summary: This study aimed to explore the differences in remission rates among rheumatoid arthritis (RA) patients using various remission-assessing methods, with a focus on the impact of patient global assessment (PGA) and other clinical variables. The results showed that the inclusion of PGA in remission formulas could significantly affect the classification of patients as being in remission. Pain, fatigue, and morning stiffness were found to be strongly associated with the remission-assessing methods that incorporated PGA. This study challenges the use of PGA in monitoring RA patients in outpatient clinics and recommends the use of measures that are less likely to be influenced by noninflammatory pain and psychosocial factors.

RHEUMATOLOGY AND THERAPY (2022)

Article Rheumatology

The effect of tofacitinib on residual Open pain in patients with rheumatoid arthritis and psoriatic arthritis

Maxime Dougados et al.

Summary: This study analyzed the effect of tofacitinib on residual pain in patients with RA and PsA. The results showed that tofacitinib had a greater reduction in residual pain compared to placebo in RA patients, but its effect was less prominent in PsA patients. The effect of tofacitinib was similar to adalimumab in reducing residual pain.

RMD OPEN (2022)

Article Rheumatology

The Problem of Pain in Rheumatology: Clinical Profiles Associated With Concomitant Diagnoses With Chronic Overlapping Pain Conditions

Titilola Falasinnu et al.

Summary: The co-occurrence of chronic overlapping pain conditions (COPCs) is common among patients with rheumatic diseases, leading to lower quality of life and greater healthcare needs. Black patients have the highest prevalence of COPCs, while Asian patients have the lowest. Patients using public insurance have a higher prevalence of COPCs.

ACR OPEN RHEUMATOLOGY (2022)

Review Rheumatology

EULAR definition of difficult-to-treat rheumatoid arthritis

Gyorgy Nagy et al.

Summary: The Task Force aimed to create recommendations for the underserved patient group with difficult-to-treat rheumatoid arthritis by drafting a definition based on international survey data among rheumatologists, nurses, health professionals, and patients. The definition includes specific criteria for treatment failure and symptom characteristics that are considered problematic by both the healthcare provider and the patient. This proposed EULAR definition can be applied in clinical practice, trials, and serve as a foundation for future research.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Review Rheumatology

Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

Maya H. Buch et al.

Summary: This review focuses on two types of refractory rheumatoid arthritis (RA) patients: those with persistent inflammatory refractory RA (PIRRA) and those with non-inflammatory refractory RA (NIRRA). Identifying individuals with predominant PIRRA or NIRRA is crucial for informing distinct treatment and management approaches for refractory RA.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Rheumatology

Difficult-to-treat rheumatoid arthritis: contributing factors and burden of disease

Nadia M. T. Roodenrijs et al.

Summary: The comprehensive study on D2T RA identified multiple contributing factors, a high burden of disease, and the heterogeneity of D2T RA subgroups. These findings suggest the importance of identifying these factors in daily practice to tailor therapeutic strategies to individual patients.

RHEUMATOLOGY (2021)

Article Rheumatology

The Jak/STAT pathway: A focus on pain in rheumatoid arthritis

Lee S. Simon et al.

Summary: Pain in rheumatoid arthritis can be treated by cytokines regulated by the Jak/STAT pathway, which play important roles in regulating inflammation and pain mechanisms.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

Review Immunology

Systemic rheumatic diseases: From biological agents to small molecules

Piercarlo Sarzi-Puttini et al.

AUTOIMMUNITY REVIEWS (2019)

Article Rheumatology

Defining refractory rheumatoid arthritis

Maya H. Buch

ANNALS OF THE RHEUMATIC DISEASES (2018)

Review Rheumatology

EULAR revised recommendations for the management of fibromyalgia

G. J. Macfarlane et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Article Medicine, General & Internal

Trends in the incidence of chronic fatigue syndrome and fibromyalgia in the UK, 2001-2013: a Clinical Practice Research Datalink study

Simon M. Collin et al.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2017)

Article Immunology

Neuron-immune mechanisms contribute to pain in early stages of arthritis

Francisco R. Nieto et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Review Rheumatology

2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria

Frederick Wolfe et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2016)

Article Rheumatology

How to measure chronic pain: New concepts

Fausto Salaffi et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2015)

Review Rheumatology

The role of sleep in pain and fibromyalgia

Ernest H. S. Choy

NATURE REVIEWS RHEUMATOLOGY (2015)

Review Rheumatology

Nociceptive neurons detect cytokines in arthritis

Hans-Georg Schaible

ARTHRITIS RESEARCH & THERAPY (2014)

Review Rheumatology

Pain in rheumatoid arthritis: a critical review

P. Sarzi-Puttini et al.

REUMATISMO (2014)

Article Rheumatology

Incidence and predictors of secondary fibromyalgia in an early arthritis cohort

Yvonne C. Lee et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

Article Rheumatology

Pain Thresholds in Rheumatoid Arthritis: The Effect of Tender Point Counts and Disease Duration

Louise C. Pollard et al.

JOURNAL OF RHEUMATOLOGY (2012)

Article Rheumatology

Fibromyalgic rheumatoid arthritis and disease assessment

Louise C. Pollard et al.

RHEUMATOLOGY (2010)

Review Clinical Neurology

Pain catastrophizing: a critical review

Phillip J. Quartana et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2009)

Article Rheumatology

Collagen-induced arthritis as a model of hyperalgesia

Julia J. Inglis et al.

ARTHRITIS AND RHEUMATISM (2007)

Article Rheumatology

Preferences for improved health examined in 1,024 patients with rheumatoid arthritis: Pain has highest priority

T Heiberg et al.

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH (2002)