Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 742, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2023.109640
Keywords
RNF106; ESCC; Hippo; LATS2; Ubiquitination
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This study reveals the oncogenic role of RNF106, a modifier of DNA methylation and histone ubiquitination, in esophageal squamous cell carcinoma (ESCC). It is found that RNF106 is involved in ESCC cell migration and invasion, and its expression is associated with poor survival in ESCC patients. Mechanistic studies demonstrate that RNF106 promotes YAP oncogenic function by regulating LATS2 ubiquitination and degradation in ESCC.
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal solid tumors in China, with the 5-year overall survival rate less than 20%. Although the carcinogenic process of ESCC is still not clear, recent studies using whole genomic profiling revealed that dysregulation of Hippo signaling pathway might play important roles in ESCC progression. The ubiquitin-like with PHD and RING finger domain 1 (RNF106) was a modifier of DNA methylation and histone ubiquitination. In this study, we evaluate the oncogenic function of RNF106 in ESCC both in vitro and in vivo. Wound healing and transwell data showed that RNF106 was required for ESCC cell migration and invasion. RNF106 depletion dramatically restrained Hippo signaling targeted gene expression. The bioinformatics analysis displayed that RNF106 was increased in ESCC tumor tissues and related with poor survival in ESCC patients. Mechanistic studies demonstrated that RNF106 was associated with LATS2 and facilitate LATS2 K48-linked ubiquitination and degradation, which subsequently inhibited YAP phosphorylation and promoted YAP oncogenic function in ESCC. Taken together, our study revealed a novel link between RNF106 and Hippo signaling in ESCC, suggesting that RNF106 could be a promising target for ESCC therapy.
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