Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives

The genus Phoma has been explored for a wide range of secondary metabolites signifying a huge range of bioactivities. Phoma sensu lato is a major group that secretes several secondary metabolites. The genus Phoma mainly includes Phoma macrostoma, P. multirostrata, P. exigua, P. herbarum, P. betae, P. bellidis, P. medicaginis, P. tropica, and many more species from the genus that are continuously being identified for their potential secondary metabolites. The metabolite spectrum includes bioactive compounds like phomenon, phomin, phomodione, cytochalasins, cercosporamide, phomazines, and phomapyrone reported from various Phoma spp. These secondary metabolites show a broad range of activities including antimicrobial, antiviral, antinematode, and anticancer. The present review is aimed to emphasize the importance of Phoma sensu lato fungi, as a natural source of biologically active secondary metabolites, and their cytotoxic activities. So far, cytotoxic activities of Phoma spp. have not been reviewed; hence, this review will be novel and useful for the readers to develop Phoma-derived anticancer agents.

Automated summary

The genus Phoma is a major group that secretes a wide range of secondary metabolites with various bioactivities. These metabolites, including phomenon, phomin, phomodione, cytochalasins, cercosporamide, phomazines, and phomapyrone, exhibit antimicrobial, antiviral, antinematode, and anticancer activities. This review highlights the importance of Phoma fungi as a natural source of biologically active secondary metabolites and their potential as anticancer agents.