4.7 Article

G-quadruplex motifs in Neisseria gonorrhoeae as anti-gonococcal targets

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Conserved G-Quadruplex Motifs Regulate Gene Expression in Neisseria meningitidis

Neha Jain et al.

Summary: Conserved G-quadruplex motifs have been found in Neisseria meningitidis, which are linked to essential genes involved in cell adhesion, pathogenesis, virulence, and DNA repair.

ACS INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Ni+2 permease system of Helicobacter pylori contains highly conserved G-quadruplex motifs

Uma Shankar et al.

Summary: This study identified and characterized conserved G-quadruplex motifs in Helicobacter pylori, which may affect the expression and function of nickel transporter genes in the bacterium. Targeting these conserved G-quadruplex motifs with bioactive molecules could potentially be a novel therapeutic approach for combating H. pylori infection.

INFECTION GENETICS AND EVOLUTION (2022)

Article Infectious Diseases

WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017-18: a retrospective observational study

Magnus Unemo et al.

Summary: Global surveillance of gonorrhoea and antimicrobial resistance in Neisseria gonorrhoeae is essential, with data from 2017-18 showing emerging resistance to ceftriaxone, cefixime, azithromycin, and ciprofloxacin. Surveillance has increased since 2015-16, but remains scarce in certain regions. Priorities include improved prevention, early diagnosis, treatment, surveillance, and the development of new antimicrobials and diagnostic tests.

LANCET MICROBE (2021)

Review Biochemistry & Molecular Biology

Regulatory role of Non-canonical DNA Polymorphisms in human genome and their relevance in Cancer

Nirali Pandya et al.

Summary: DNA has the ability to form various polymorphic structures, which play important roles in gene expression and biological functions. Non-canonical structures are involved in regulating gene expression, DNA repair, and other biological processes, and their presence can impact cellular machinery and even contribute to diseases like cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Chemistry, Medicinal

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

Ruben Cebrian et al.

Summary: The study tested a G4-DNA ligand library based on the NDI pharmacophore for its biological activity against Gram-positive and Gram-negative bacteria. The best compound, NDI-10, was found to have different action mechanisms for the two types of bacteria, possibly due to the different prevalence of putative G4-DNA structures in each group.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Microbiology

G-Quadruplex Structures in Bacteria: Biological Relevance and Potential as an Antimicrobial Target

Puja Yadav et al.

Summary: G4 DNA, with its noncanonical structure, plays crucial roles in transcriptional and translational regulation, DNA replication, genome stability, and oncogene expression in eukaryotic genomes. Research on the biological roles of G4 DNA and G4 RNA in plants and bacterial pathogens is showing conservation and potential applications.

JOURNAL OF BACTERIOLOGY (2021)

Review Biochemistry & Molecular Biology

G-quadruplex DNA structures and their relevance in radioprotection

Nitu Kumari et al.

Summary: This review discusses the relationship between DNA secondary structure formation, GC content, and G-quadruplex formation with radiosensitivity of the genome in different organisms. It highlights the role of these factors in shielding the genome from radiation and understanding the evolution of radio protective effects.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

Article Chemistry, Medicinal

Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs

Chiara Platella et al.

Summary: Naphthalene diimides (NDIs) show high potential as anticancer agents by targeting multiple G-quadruplexes simultaneously and demonstrating strong, selective anticancer activity. Analysis of biophysical and biological data yields structure-activity correlations, while in-depth discussion of NDI binding modes to G-quadruplexes is based on available structural models.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

G-Quadruplexes as pathogenic drivers in neurodegenerative disorders

Ernest Wang et al.

Summary: G-quadruplexes (G4s), higher-order DNA and RNA secondary structures with various conformations, play important roles in cellular processes and may have an impact on the pathogenic cascades of neurological diseases. Further research is needed to fully understand their functions and potential implications in disease development.

NUCLEIC ACIDS RESEARCH (2021)

Article Biochemical Research Methods

ShinyGO: a graphical gene-set enrichment tool for animals and plants

Steven Xijin Ge et al.

BIOINFORMATICS (2020)

Review Medical Laboratory Technology

The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae

Daniel H. F. Rubin et al.

TRANSLATIONAL RESEARCH (2020)

Review Cell Biology

The regulation and functions of DNA and RNA G-quadruplexes

Dhaval Varshney et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Characterization of highly conserved G-quadruplex motifs as potential drug targets in Streptococcus pneumoniae

Subodh Kumar Mishra et al.

SCIENTIFIC REPORTS (2019)

Review Biochemistry & Molecular Biology

Parasitic Protozoa: Unusual Roles for G-Quadruplexes in Early-Diverging Eukaryotes

Franck Dumetz et al.

MOLECULES (2019)

Article Medicine, Research & Experimental

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

Subodh Kumar Mishra et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Biochemistry & Molecular Biology

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

Emanuela Ruggiero et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemical Research Methods

shinyCircos: an R/Shiny application for interactive creation of Circos plot

Yiming Yu et al.

BIOINFORMATICS (2018)

Article Multidisciplinary Sciences

Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions

Rosalba Perrone et al.

SCIENTIFIC REPORTS (2017)

Article Chemistry, Multidisciplinary

Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Zoe A. E. Waller et al.

CHEMICAL COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Re-evaluation of G-quadruplex propensity with G4Hunter

Amina Bedrat et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

G4IPDB: A database for G-quadruplex structure forming nucleic acid interacting proteins

Subodh Kumar Mishra et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

nagZ Triggers Gonococcal Biofilm Disassembly

Senthil V. Bhoopalan et al.

SCIENTIFIC REPORTS (2016)

Article Pharmacology & Pharmacy

Methods for in vitro evaluating antimicrobial activity: A review

Mounyr Balouiri et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2016)

Review Microbiology

G-Quadruplexes in Pathogens: A Common Route to Virulence Control?

Lynne M. Harris et al.

PLOS PATHOGENS (2015)

Article Biochemistry & Molecular Biology

A Matter of Location: Influence of G-Quadruplexes on Escherichia coli Gene Expression

Isabelle T. Holder et al.

CHEMISTRY & BIOLOGY (2014)

Article Chemistry, Multidisciplinary

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

Vineeth Thachappilly Mukundan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Biochemistry & Molecular Biology

Quadruplex DNA: sequence, topology and structure

Sarah Burge et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Immunology

Biofilm formation by Neisseria gonorrhoeae

LL Greiner et al.

INFECTION AND IMMUNITY (2005)

Article Biochemistry & Molecular Biology

Prevalence of quadruplexes in the human genome

JL Huppert et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Biochemistry & Molecular Biology

WebLogo: A sequence logo generator

GE Crooks et al.

GENOME RESEARCH (2004)