4.7 Article

Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 92, Pages 16518-16521

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07340e

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Funding

  1. National Natural Science Foundation of China [21322507, 21175072]
  2. Fundamental Research Funds for the Central Universities

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We report that QATPE, an aggregation-induced emission-active tetraphenylethene dye, can be used as a non-sequence-specific ssDNA probe for real-time monitoring of all rolling circle amplification (RCA) reactions, thus making RCA more suitable for biosensing applications.

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