Dosimetric Identification of Gamma-Irradiated Progesterone and Propranolol Hydrochloride by Electron Paramagnetic Resonance Spectroscopy

In this study, radiation sensitivities of progesterone and propranolol hydrochloride samples irradiated with gamma in the 0-25 kGy dose range, which are widely used in medicine, were investigated by electron paramagnetic (EPR) resonance spectroscopy. Since the microwave saturation behavior of free radicals contributing to the spectra may be different, curves of signal intensities of the irradiated samples were obtained in the range of 0-15 mW depending on the microwave power. By using irradiated samples at dose values of 1, 5, 10, 15, 20 and 25 kGy, dose-response curves of the samples were obtained and the most appropriate mathematical functions and correlation coefficients were calculated. In addition, the extinction curves of the signal intensities of the samples were determined to test the stability of the free radicals formed in the irradiated samples at room temperature.

Automated summary

The radiation sensitivities of progesterone and propranolol hydrochloride samples irradiated with gamma rays in the 0-25 kGy dose range were investigated using electron paramagnetic resonance (EPR) spectroscopy. The microwave saturation behavior of the free radicals contributing to the spectra was found to be different, resulting in signal intensity curves obtained in the range of 0-15 mW depending on the microwave power. Dose-response curves were obtained using samples irradiated at dose values of 1, 5, 10, 15, 20, and 25 kGy, and the most appropriate mathematical functions and correlation coefficients were calculated. The stability of the free radicals formed in the irradiated samples at room temperature was tested by determining the extinction curves of the signal intensities.