Journal
ANTIVIRAL RESEARCH
Volume 216, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2023.105672
Keywords
Herpes simplex virus; Antiviral resistance; NGS; UL23 gene; UL30 gene
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This study reports the identification of novel UL23 and UL30 substitutions in immunocompromised patients with HSV1 and HSV2, which contributes to the completion of the HSV1 and HSV2 substitution database and enhances accurate diagnosis of related diseases.
Data on herpes simplex virus (HSV) polymorphism as well as acyclovir (ACV) and foscarnet (FOS) resistance mutations are not exhaustive and may hinder accurate diagnosis by next-generation sequencing (NGS). Here, we report novel UL23 and UL30 substitutions for HSV1 and HSV2 identified in immunocompromised patients treated for hematological malignancies during the last 6 years of HSV resistance surveillance at the University Hospital of Lyon. For HSV1, 35 novel UL23 substitutions and 52 novel UL30 substitutions were identified. For HSV2, 2 novel UL23 substitutions and 12 novel UL30 substitutions were identified. These results allow to complete the database of HSV1 and HSV2 substitutions, related either to polymorphism or to ACV and FOS resistance.
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