Journal
ANTIVIRAL RESEARCH
Volume 218, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2023.105713
Keywords
Enterovirus A71; HFMD; CUR-N399; PI4KB inhibitor; Infection; Antiviral
Categories
Ask authors/readers for more resources
Hand, foot and mouth disease (HFMD) is a common disease that mainly affects young children. This study discovers a broad-spectrum antiviral inhibitor called CUR-N399, which shows therapeutic effects against enterovirus A71 (EV-A71) infection in mice.
Over the years, the hand, foot and mouth disease (HFMD) has sparked epidemics across many countries which mainly affected young children. While symptoms are usually mild, severe complications may arise, and some even lead to death. Such concerns, coupled with the lack of approved vaccines and antivirals to date, create an urgency in the identification of safe therapeutics against HFMD. The disease is mainly transmitted by enteroviruses like enterovirus A71 (EV-A71). Essential for enterovirus replication is the host protein, PI4KB. In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available