Journal
MEDICAL CLINICS OF NORTH AMERICA
Volume 100, Issue 1, Pages 31-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2015.08.004
Keywords
Nociceptive processes; Neuropathic pain; Cold hyperalgesia; Peripheral nerve injury; Wind-up pain; Central sensitization; Pain pathophysiology
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We discuss the complex features of the pathophysiology of chronic pain and the implications for treatment and provide an overview of nociceptive processes, neuropathic pain, cold hyperalgesia, peripheral nerve injury, wind-up pain, central sensitization, and common clinical presentation and diagnostic criteria. Advanced medicine has proven that chronic pain need not involve any structural pathology as pain is a complex biopsychosocial experience. Treatment of the specific mechanisms responsible for pain should be aimed at preventing and or reducing dysfunctional neuro-plasticity resulting from poorly controlled chronic pain. Further study is needed to reduce the probability and of persistent changes that cause chronic pain.
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