4.7 Article

Granzyme B (GZMB)-Positive Tumor-Infiltrating Lymphocytes in Lung Adenocarcinoma: Significance as a Prognostic Factor and Association with Immunosuppressive Proteins

Related references

Note: Only part of the references are listed.
Article Oncology

Preventive effect of tertiary lymphoid structures on lymph node metastasis of lung adenocarcinoma

Sho Wakasu et al.

Summary: This study found that mature tertiary lymphoid structures (TLSs) were associated with a lower frequency of lymph node metastasis and favorable outcomes. Mature TLSs may support antitumor immunity by activating lymphocytes.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

Article Oncology

Granzyme B for predicting the durable clinical benefit of anti-PD-1/PD-L1 immunotherapy in patients with non-small cell lung cancer

Jae Heun Chung et al.

Summary: In this study, we identified the sequential change in granzyme B as a predictive biomarker for immune checkpoint inhibitor therapy in patients with non-small cell lung cancer. Additionally, the change in granzyme B levels was associated with progression-free survival and overall survival.

TRANSLATIONAL CANCER RESEARCH (2022)

Article Oncology

Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB-IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial

Mary O'Brien et al.

Summary: This study evaluated the use of Pembrolizumab as adjuvant therapy for completely resected stage IB-IIIA NSCLC. The results showed that Pembrolizumab significantly improved disease-free survival in both the overall population and the PD-L1 TPS of 50% or greater population.

LANCET ONCOLOGY (2022)

Article Medicine, General & Internal

Adjuvant atezolizumab after adjuvant chemotherapy in resected stage IB-IIIA non-small-cell lung cancer (IMpower010): a randomised, multicentre, open-label, phase 3 trial

Enriqueta Felip et al.

Summary: IMpower010 study demonstrated a disease-free survival benefit with adjuvant atezolizumab versus best supportive care in patients who underwent complete resection followed by adjuvant chemotherapy, especially in the subgroup whose tumors expressed PD-L1 on 1% or more of tumor cells.

LANCET (2021)

Article Multidisciplinary Sciences

Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy

Anh Nguyen et al.

SCIENCE ADVANCES (2020)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Immunology

IDO1 in cancer: a Gemini of immune checkpoints

Lijie Zhai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

Article Medicine, General & Internal

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

S. J. Antonia et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Immunotoxins in cancer therapy: Review and update

Bahman Akbari et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2017)

Article Oncology

Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response

Benjamin M. Larimer et al.

CANCER RESEARCH (2017)

Article Cell Biology

Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis

Yiting Geng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

Article Oncology

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

Luis Martinez-Lostao et al.

CLINICAL CANCER RESEARCH (2015)

Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Medical Laboratory Technology

Surface markers of lymphocyte activation and markers of cell proliferation

Maria Shipkova et al.

CLINICA CHIMICA ACTA (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Review Biochemistry & Molecular Biology

Granzymes in cancer and immunity

S. P. Cullen et al.

CELL DEATH AND DIFFERENTIATION (2010)