4.4 Editorial Material

Marginal Zone

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons

Daxing Gao et al.

Summary: Human herpes simplex virus 1 encephalitis can be caused by inborn errors of the TLR3 pathway, leading to impaired CNS cell-intrinsic antiviral immunity. Deficiencies in TLR3 pathway impair cell-intrinsic immunity to various viruses, and the mechanism involves impaired IFN-alpha/beta induction. Human TLR3 controls constitutive levels of IFNB mRNA and bioactive IFN-beta protein, as well as the basal levels of ISG mRNA in fibroblasts and cortical neurons.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Multidisciplinary Sciences

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Fabien G. Lafaille et al.

NATURE (2012)