Journal
MEDIATORS OF INFLAMMATION
Volume 2016, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2016/9894504
Keywords
-
Categories
Funding
- Ministerio de Economia y Competitividad of Spain [SAF2014-56671-R]
- Universidad CEU San Pablo [USP-BS-APP03/2014]
- Banco de Santander
- Fundacion Universitaria San Pablo CEU
Ask authors/readers for more resources
Midkine (MK) is a cytokine that modulates amphetamine-induced striatal astrogliosis, suggesting a possible role of MK in neuroinflammation induced by amphetamine. To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10mg/kg i.p. four times, every 2 h) in different brain areas of MK-/-mice and wild type (WT) mice. We found that amphetamine-induced microgliosis and astrocytosis are enhanced in the striatum of MK-/-mice in a region-specific manner. Surprisingly, LPS-induced astrogliosis in the striatum was blocked in MK-/-mice. Since striatal neuroinflammation induced by amphetamine-type stimulants correlates with the cognitive deficits induced by these drugs, we also tested the long-term effects of periadolescent amphetamine treatment (3mg/kg i.p. daily for 10 days) in a memory task in MK-/-and WT mice. Significant deficits in the Y-maze test were only observed in amphetamine-pretreated MK-/-mice. The data demonstrate for the first time that MK is a novel modulator of neuroinflammation depending on the inflammatory stimulus and the brain area considered. The data indicate that MK limits amphetamine-induced striatal neuroinflammation. In addition, our data demonstrate that periadolescent amphetamine treatment in mice results in transient disruption of learning and memory processes in absence of endogenous MK.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available