Journal
MEDIATORS OF INFLAMMATION
Volume 2016, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2016/7432845
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Funding
- Chinese Academy of Sciences [161343KYSB20160008]
- National Key Research and Development Program of China [2016YFD0500504]
- National Natural Science Foundation of China [31672457, 31402092]
- Ministry of Agricultural of the People's Republic of China [2015-Z64, 2016-X47]
- Hunan Provincial Science and Technology Department [2016NK2101, 2016WK2008, 2016TP2005]
- King Saud University, through Vice Deanship of Research Chairs
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This study aims to investigate the effects of dietary chitosan (COS) on gastrointestinal pathogen resistance in mice model. For two weeks, a control group of ICR mice received a basal diet whilst the intervention group received the basal diet supplemented with 300mg/kg COS. After two weeks, the mice fed the supplemented diet had a lower body weight. Then enterotoxigenic Escherichia coli (E. coli) was administered to the mice through oral gavage, with each mouse receiving 10(8) CFU. At day 7 after infection, the bacterial load in the jejunum and faeces was significantly lower in the COS group than that in the control group. Moreover, the mRNA and protein levels of IL-1 beta, IL-6, IL-17, IL-18, and TNF-alpha were significantly lower in the group of mice receiving the COS diet; also the jejunal production of toll-like receptor-4 (TLR-4) was suppressed in the COS group. These results indicate the intervention influenced inflammation and controlled E. coli infection.
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