Reply to Correspondence on Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1''

The high-resolution X-ray crystal structure of the ternary complex FtmOx1 center dot 2OG center dot fumitremorgin B and the catalytic mechanism were recently reported by us (DOI 10.1002/anie.202112063). In their Correspondence, Zhang, Costello, Liu et al. criticize our work in several aspects. Herein, we address these questions one by one. These structural clarifications and new computational results further support the CarC-like mechanistic model.

Automated summary

The high-resolution X-ray crystal structure of the ternary complex FtmOx1 center dot 2OG center dot fumitremorgin B and its catalytic mechanism were reported. In response to criticism from Zhang, Costello, Liu et al., the authors address their questions and provide structural clarifications and new computational results that support the CarC-like mechanistic model.