Voltage-Mediated Water Dynamics Enables On-Demand Transport of Sugar Molecules in Two-Dimensional Channels

The constructing of artificial channels with gating functions is an important undertaking for gaining insight into biological process and achieving efficient bionic functions. Typically, controllable transport within such channels relies on either electrostatic or specific interactions between the transporting species and the channel. However, for molecules with weak interactions with the channel, achieving precise gating of the transport remains a significant challenge. In this regard, this study proposes a voltage gating membrane of two-dimensional channels that selectively transport of neutral molecules glucose with a dimension of 0.60 nm. The permeation of glucose is switched on/off by electrochemically manipulating the water dynamics in the nanochannel. Voltage driven-intercalation of ion into the two-dimensional channel causes water to stratify and move closer to the channel walls, thereby resulting in the channel center being emptier for glucose diffusion. Due to the sub-nanometer size dimension of the channel, selective permeation of glucose over sucrose is also achieved in this approach.

Automated summary

The construction of artificial channels with gating functions is crucial for understanding biological processes and achieving efficient bionic functions. In this study, a voltage gating membrane of two-dimensional channels is proposed, which selectively transports neutral glucose molecules with a dimension of 0.60 nm. The permeation of glucose is controlled by manipulating the water dynamics in the nanochannel through electrochemical means. The sub-nanometer size of the channel enables selective permeation of glucose over sucrose.