Recent Developments with Organogermanes: their Preparation and Application in Synthesis and Catalysis

Within the sphere of traditional Pd0/PdII cross coupling reactions, organogermanes have been historically outperformed both in terms of scope and reactivity by more conventional transmetalating reagents. Subsequently, this class of compounds has been largely underutilized as a coupling partner in bond-forming strategies. Most recent studies, however, have shown that alternative modes of activation of these notoriously robust building blocks transform organogermanes into the most reactive site of the molecule-capable of outcompeting other functional groups (such as boronic acids, esters and silanes) for both C-C and C-heteroatom bond formation. As a result, over the past few years, the literature has increasingly featured methodologies that explore the potential of organogermanes as chemoselective and orthogonal coupling partners. Herein we highlight some of these recent advances in the field of organogermane chemistry both with respect to their synthesis and applications in synthetic and catalytic transformations. Organogermanes have historically been underutilized as prospective coupling partners. Recent studies have uncovered alternative activation modes that unlocked their chemoselective and orthogonal reactivity, thereby transforming the germanium motif into the most reactive site on a given substrate. Herein are shown some of the latest advances for organogermane chemistry with respect to their application in synthetic transformations and preparation.image

Automated summary

Within the traditional Pd0/PdII cross coupling reactions, organogermanes have been historically underutilized as coupling partners. Recent studies have discovered alternative activation modes that unlock their chemoselective and orthogonal reactivity, making the germanium motif the most reactive site on a given substrate. Herein, we highlight some of the latest advances in organogermane chemistry, particularly in synthetic transformations and preparation.