Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202308880
Keywords
C-F Activation; Defluorofunctionalization; Fluorine; Synthesis Design; Synthetic Methods
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This article summarizes the development and application of C-F bonds, focusing on the advantages of defluorination reactions in small molecule synthesis and illustrating how defluorofunctionalization can streamline synthesis and enable new reactions. The goal of the article is to educate chemists on the opportunities available for incorporating C-F bonds and exploiting their unique mechanistic pathways.
Much progress has been made in the development of methods to both create compounds that contain C-F bonds and to functionalize C-F bonds. As such, C-F bonds are becoming common and versatile synthetic functional handles. This review summarizes the advantages of defluorinative functionalization reactions for small molecule synthesis. The coverage is organized by the type of carbon framework the fluorine is attached to for mono- and polyfluorinated motifs. The main challenges, opportunities and advances of defluorinative functionalization are discussed for each class of organofluorine. Most of the text focuses on case studies that illustrate how defluorofunctionalization can improve routes to synthetic targets or how the properties of C-F bonds enable unique mechanisms and reactions. The broader goal is to showcase the opportunities for incorporating and exploiting C-F bonds in the design of synthetic routes, improvement of specific reactions and advent of new methods. This review summarizes the advantages of using C-F bonds as functional handles for chemical synthesis. Specific examples are used to illustrate how defluorofunctionalization can streamline small molecule synthesis and enable new reactions. The goal of this review is to educate chemists on the opportunities available for incorporating C-F bonds in synthetic route planning and for exploiting the unique mechanistic pathways available to C-F bonds.image
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