Related references
Note: Only part of the references are listed.
Article
Chemistry, Analytical
Feng Tian et al.
Summary: In this study, an endogenously and sequentially activated signal amplification strategy was constructed to achieve dual color fluorescence imaging of microRNA in living cancer cells. The designed nanoprobe could achieve high precision and reliability for microRNA bioimaging in cancer cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Ling Jiang et al.
Summary: In this study, a novel CRISPR/Cas13a-mediated photoelectrochemical biosensor was proposed for the direct assay of miRNA-21, which showed improved specificity and sensitivity compared to traditional nucleic acid-based strategies. The CRISPR/Cas13a system accurately recognized and efficiently cleaved the target, without the need for complex nucleic acid sequence design. This biosensor demonstrated excellent analysis capability and stability, suggesting promising application prospects in early disease diagnosis and biomedical research.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mengyuan He et al.
Summary: An ultrasensitive molecular beacon probe was developed for microRNA-21 determination using carbon dots as energy donor and organic dye, and graphene oxide as synergistic quencher. The fluorescence of carbon dots was decreased by luminescence resonance energy transfer when conjugated to the molecular beacon. Introducing graphene oxide as a quencher effectively enhanced the energy transfer efficiency. In the presence of microRNA-21, the probe exhibited fluorescence recovery due to the inhibition of the energy transfer process. The probe showed excellent specificity and could be used for miRNA-21 determination in a wide range of concentrations.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Shihua Li et al.
Summary: Photoluminescence (PL) imaging is a critical tool for disease diagnosis, therapeutic evaluation, and surgical navigation. However, developing high-efficiency nanoprobes for in vivo imaging and clinical translation remains a challenge. This review discusses the progress in engineering sub-10 nm ultrasmall luminescent nanoprobes for in vivo PL bioimaging and highlights their unique advantages. The challenges in this field and strategies for improving in vivo PL bioimaging and clinical applications are also addressed.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Fanfan Yu et al.
Summary: Highly luminescent and functionalized gold nanocluster nano-assembled structures were fabricated through poly-l-arginine surface engineering for improved luminescence. These assemblies were used for imaging glutathione molecules in cells and living organisms with low background and high sensitivity.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Shujing Wang et al.
Summary: In this study, a series of multiphoton terpyridine agents were designed and synthesized for fluorescence lifetime imaging microscopy (FLIM). The N-hexylated terpyridine salt, ZA-Hex, showed stronger three-photon aggregation-induced emission (AIE) properties compared to ZA-Mex. These terpyridine derivatives exhibited suitable fluorescence intensities and stable fluorescence lifetimes under different pH conditions, enabling multiphoton fluorescence lifetime imaging. ZA showed good lipid droplet (LD) turn-on fluorescence performance, and ZA-Hex exhibited high specificity for accumulation in mitochondria. This is the first report of terpyridine salts as three-photon AIE probes for multiphoton FLIM imaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chan Yang et al.
Summary: A new two-photon nanoprobe (TP-CHA-MOFs) was developed using MOF as nanocarrier and hairpins as a two-photon fluorescence signal amplifier for intracellular miRNA imaging. The nanoprobe showed high loading capacity, stability, and biocompatibility. It achieved sensitive imaging of intracellular miRNA in tumor cells with different levels and deep tumor tissues.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xin Xu et al.
Summary: This study developed an ATP-responsive DNA nanohydrogel for cancer cells specific fluorescence imaging and chemotherapy. The nanohydrogel disassembled and released the loaded drug after endocytosis by cancer cells and response to high intracellular ATP level. The released drug played a role in fluorescence imaging and chemotherapy of cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zizhong Yang et al.
Summary: The Hairpins@MnO2 nanosystem enables enzyme-free exponential amplification for miRNA imaging in living cells, offering high sensitivity and specificity. The method combines HCR and DNAzymes for efficient amplification, with a detection limit much lower than traditional HCR systems. It allows accurate differentiation of miRNA expression in cancer cells and normal cells, showing great potential in nucleic acid biological research.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mengyao Zhao et al.
Summary: In this study, we designed and synthesized a tumor-responsive and easily synthesized material for luminescence lifetime sensor, which allowed accurate identification and quantification of cells and tumors with high redox state. The material exhibited the capability of controlling luminescence lifetimes in the second near-infrared window.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yuping Zhao et al.
Summary: This study proposed a new strategy to investigate the interaction regulatory mechanisms between endoplasmic reticulum and autophagosomes by developing dual fluorescence lifetime probes localized to these two organelles. The research revealed that motile autophagosomes at the tips of endoplasmic reticulum drive the growth and sliding of ER tubules, ER reticulate tubules form a three-way junction centered on autophagosomes, and ER autophagy serves as a cell damage index during drug-induced apoptosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Hongyu Chen et al.
Summary: This study develops a separation layer suitable for the preparation of plasmon-enhanced gold nanoclusters (AuNCs) luminescent nanomaterials. Bovine serum albumin (BSA) is used as the separation layer to prepare AuNPs@BSA@Au35NCs through a controllable and in situ synthesis method. Compared with the previously reported silica layer, the BSA layer preparation is simpler, time-saving, and improves the quantum yield of AuNCs.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Zizhong Yang et al.
Summary: This study presents a Hairpins@MnO2 nanosystem for intracellular enzyme-free exponential amplification for miRNA imaging. The method combines hybridization chain reaction (HCR) and DNAzymes for efficient miRNA detection. The introduced nanosystem allows for a highly sensitive and specific detection of miRNA expression in living cells, with a detection limit 2.4 x 10(4) times lower than traditional HCR system.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Dan Sun et al.
Summary: Analysis of single-cell microRNA is essential for revealing genetic heterogeneity at the cell level. In this study, SERS and fluorescence imaging technology were used to achieve direct in situ, nondestructive, and highly sensitive detection of a small number of microRNA-21 (miR-21) in a single intact living cell. A multifunctional plasmonic nanoprobe was designed, allowing for highly sensitive and reliable detection of miR-21 through dual-signal switching. The combination of SERS and microdroplets encapsulation provided a feasible way to determine miR-21 secreted by single cells without cell lysis and time-consuming isolation steps. The research accurately and quantitatively evaluated the cellular heterogeneity in miR-21 expression, providing important reference information for understanding the effects of miRNAs on cancer diseases at the single-cell level.
Article
Chemistry, Analytical
Yuan Wang et al.
Summary: This study developed a fluorescence lifetime thermometer with high sensitivity and stability for detecting the temperature of intracellular mitochondria, utilizing modified Au nanoclusters. The thermometer successfully detected temperature changes at L929 cells' mitochondria under different stimuli, using fluorescence lifetime images of the nanoclusters.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Peng He et al.
Summary: The study presented an integrated smart nanodevice composed of Au@Cu2-xS@polydopamine nanoparticles and fuel DNA-conjugated tetrahedral DNA nanostructures for antitumor therapy and miRNA detection. Utilizing a SERS-FL dual-spectrum biosensor, the device achieved high detection sensitivity and low background signal for improved accuracy in diagnosing cancer cell miRNA.
Review
Chemistry, Multidisciplinary
Kingshuk Dutta et al.
Summary: Nucleic acids have potential applications in gene therapy and vaccine development, but their effective clinical translation faces significant challenges, with traditional design concepts of nucleic acid drug carriers being a major issue due to potential cytotoxicity. Innovative carrier designs using charge-conversion approaches have been proposed to overcome critical barriers in therapeutic delivery, such as serum deactivation and endosomal escape.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Qian Li et al.
Summary: A new fluorescence strategy based on S-S-AuNCs was proposed for highly sensitive detection of organophosphorus pesticides without additional substances. S-S-AuNCs exhibited unique responses to thiol compounds and low pH values, and were utilized to monitor the residue, distribution, and metabolization of organophosphorus pesticides in pakchoi.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Hongmei Zhong et al.
Summary: Dual-mode imaging, combining TP fluorescence imaging and MRI, shows promise in improving accuracy for early disease diagnosis, especially in pH-related diagnosis and treatment, with great potential to enhance clinical efficacy.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Puspam Keshri et al.
Summary: Fluorescence lifetime-based imaging and quantification of intercellular molecular tensions offer a novel approach to simultaneously measure tensile forces among multiple ligand-receptor pairs. This method was validated and DNA tension probes were developed for imaging E-cadherin-mediated tension, which were further applied to quantify the correlations between E-cadherin and N-cadherin tensions during an epithelial-mesenchymal transition process. The modular design of these probes has the potential to study the mechanical features of various physiological and pathological processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hongmei Zhong et al.
Summary: The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, utilizing two-photon carbon quantum dots and MnO2, is developed for two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment. It shows high selectivity, a great signal-to-noise ratio, a LOD of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 μm.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Rongcheng Han et al.
Article
Chemistry, Multidisciplinary
Ran Liu et al.
Review
Chemistry, Multidisciplinary
Friedrich C. Simmel et al.
Article
Chemistry, Analytical
Cheng Zhang et al.
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Yaokun Xia et al.
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Diego Bouzas-Ramos et al.
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Ying Yang et al.
CHEMICAL COMMUNICATIONS
(2018)
Review
Chemistry, Multidisciplinary
Shuqing He et al.
CHEMICAL SOCIETY REVIEWS
(2018)
Article
Chemistry, Multidisciplinary
Xinxin Jiang et al.
Article
Chemistry, Analytical
Sujuan Ye et al.
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Xue Xiao et al.
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Analytical
Xiaohong Tan et al.
ANALYTICAL CHEMISTRY
(2012)
Article
Chemistry, Multidisciplinary
Zhentao Luo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Review
Chemistry, Multidisciplinary
Mikhail Y. Berezin et al.