Related references
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Article
Multidisciplinary Sciences
Wei Huang et al.
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Chemistry, Multidisciplinary
Zheng Li et al.
Summary: Here we report a high-gain signal-on PEDOT:PSS OECT biosensing system using a light-fueled MXene/MOFs/NiO Schottky heterojunction. The system showed remarkable current gain as high as near 10^4, which is the highest among existing OECT biosensory devices. This work provides a generic protocol for developing novel signal-on PEDOT:PSS OECT platforms for biochemical detection and beyond.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Yi-Tong Xu et al.
Summary: By integrating a monocrystalline silicon solar cell into the circuit of an organic photoelectrochemical transistor (OPECT), the possibility of self-powered and light-modulated operation of OPECT optoelectronics was demonstrated. Different light-addressable configurations were constructed using depletion-mode and accumulation-mode OECTs, and their characteristics were systematically studied and compared. Light-controlled OPECT unipolar inverters were designed with various parameters depending on the incident irradiance, and optimization was done with respect to the power source and resistance. This work combines OPECT optoelectronics with flexible substrates and solar cells for potential applications in portable and wearable devices.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ge Gao et al.
Summary: This study addresses the challenge of achieving maximum transconductance (g(m)) at zero gate bias (V-G) in organic electrochemical transistors. By utilizing unique light-matter interplay in the newly emerged technique of organic photoelectrochemical transistor (OPECT), a dual-ligand photosensitive metal-organic framework (DL-PS-MOFs)/TiO2 nanorods (NRs) gated poly(ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) OPECT is developed, demonstrating enhanced performance with maximum g(m) at zero V-G. The device is further biologically interfaced with a miRNA-triggered growth of DNA spheres for sensitive miRNA-21 detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Feng-Zao Chen et al.
Summary: This study presents a biosensor based on MOF-on-MOF-derived semiconductor heterojunctions, which relies on the bioinduced AgI transition on ZnO@In2O3@AgI. The photocurrent switches from cathodic to anodic due to the generation of ZnO@In2O3@In2S3@Ag2S heterojunctions by bioproduced H2S. The biosensor shows good selectivity and sensitivity for detecting NSE with a low detection limit of 0.58 pg/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Peng Qu et al.
Summary: Organicphotoelectrochemical transistor (OPECT) biosensing is a promising approach for biomolecular sensing. This work demonstrates the direct enzymatic biocatalytic precipitation (BCP) modulation on a flower-like Bi(2)S(3) photosensitive gate, achieving high-efficiency OPECT operation with high transconductance (g (m)). The developed OPECT aptasensor shows good analysis performance for prostate-specific antigen (PSA).
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Cheng Yuan et al.
Summary: This study developed a polymer dot (Pdot)-gated accumulation-type organic photoelectrochemical transistor (OPECT) biosensor for sensitive urea detection. The Pdot/PTAA gating module showed superior performance compared to the de-doped PEDOT:PSS channel, and the urea-dependent status of Pdots was found to be correlated with the device's response. High-performance urea detection was achieved with a wide linear range of 1 μM-50 mM and a low detection limit of 195 nM. This work represents a generic platform for developing advanced accumulation-type OPECT and beyond, taking into account the diversity of the Pdot family and its interactions with other species.
Article
Chemistry, Multidisciplinary
Yizhou Zhong et al.
Summary: Organic photodiodes (OPDs) have the potential to be used in flexible, lightweight, and miniaturized photodetectors for wearable applications. However, the current and light responsivity of OPDs are limited, and alternative methods are needed to enhance the signal response. In this study, a miniaturized organic electrochemical transistor (OECT) is integrated with an OPD module to harness the potential of OPDs in acquiring physiological signals. The integrated photodetector (IPD) system uses the light intensity to regulate the OPD voltage output, which in turn modulates the OECT channel current. The high transconductance of the OECT enables efficient voltage-to-current conversion, improving the signal-to-noise ratio at the sensing site. The IPD achieves significantly higher photocurrent and responsivity compared to the standalone OPD, highlighting its potential as a wearable biosensor for detecting weak light-based signals from living systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Cheng-Jie Li et al.
Summary: Biomolecules-incorporated MOFs have been used as innovative gating modules for organic devices, demonstrating a variant gating effect based on sensitive responses. This study provides a proof-of-concept for the development of biomolecules-MOFs-gated electronics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiajun Song et al.
Summary: In this study, a high-performance flexible photodetector is realized by gating an organic electrochemical transistor with a perovskite solar cell. The device exhibits high gain, fast response time, and ultrahigh detectivity under a low working voltage, allowing it to track photoplethysmogram signals and peripheral oxygen saturation. This work offers a novel strategy for high-performance flexible photodetectors in low-power, user-friendly, and wearable optoelectronics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Rui Ban et al.
Summary: Organic photoelectrochemical transistor (OPECT) bioanalytics has emerged as a promising approach for biological measurements, with implications in next-generation photoelectrochemical (PEC) bioanalysis and future biorelated implementations. The combination of biological dissociation and bioetching has the potential to achieve innovative OPECT bioanalytics. In this study, alkaline phosphatase (ALP)-mediated bioetching of a CoOOH/BiVO4 gate was demonstrated for signal-on OPECT immunoassay of human immunoglobulin G (HIgG). The biosensor achieved sensitive detection of HIgG with high selectivity and sensitivity, showcasing bioetching-enabled high-efficacy OPECT bioanalysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zheng Li et al.
Summary: This study demonstrates a H-cell-supported OPECT device that solves the shared electrolyte issue and enables binding-free detection of membrane ALP in HeLa cells. The sensitization of TiO2 nanotubes electrode by ALP catalytic chemistry triggers altered channel currents.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jin Hu et al.
Summary: Advanced organic bioelectronics enable seamless integration between modern electronics and biological systems, leading to improved physiological monitoring and pathological examinations. Photon-regulated bioelectronics, which offer non-contact impact, remote control, and self-powered operation, are highly desirable. However, there have been limited studies on advanced photon-enabled organic photoelectrochemical transistor (OPECT) biosensors operating at zero gate bias.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Analytical
Yuan Gao et al.
Summary: This study presents a new liposome-mediated method for highly sensitive photoelectrochemical (PEC) immunoassays by forming a ZIS NSs/SnS2 type-I heterojunction on FTO electrodes. The PEC sensor constructed showed good stability and selectivity for heart-type fatty acid binding protein (h-FP), with a high sensitivity dynamic linear response range of 0.1-1000 pg/mL and a lower detection limit of 55 fg/mL.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Feng-Zao Chen et al.
Summary: This work presents a high-performance MOF-based photoelectrochemical sensor for the detection of tetracycline. By combining with ZnIn2S4 nanosheets and fluorine-doped tin oxide, it can reduce the photocurrent signal through interaction with tetracycline. The sensor exhibits fast response to ultra-low concentrations of tetracycline.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
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Materials Science, Multidisciplinary
Yi-Tong Xu et al.
Summary: Organic photoelectrochemical transistors modulate the invisible ionic circuit, allowing for unique photonic electronics towards logic and sensor applications. This work not only represents new photonic bioelectronics but also provides a generic mechanism for the design and development of advanced opto-logics and bio-analytics.
ADVANCED OPTICAL MATERIALS
(2022)
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Multidisciplinary Sciences
Sophia L. Bidinger et al.
Summary: This study demonstrates the translation of the AC pulsed potential approach to an organic electrochemical transistor (OECT) and shows the current modulation effect achieved through aptamer functionalization. Unlike traditional EAB sensors, this aptamer-based OECT sensor maintains stable output current even with miniaturization.
Article
Chemistry, Multidisciplinary
Hai-Yan Wang et al.
Summary: This study explores a new technological direction in single-cell analysis by utilizing the rich interplay between light and bio-matter. A PEC nanoreactor is designed for single-cell sampling and detection of intracellular microRNA. The use of light stimulation enables zero-background Faradaic detection of non-electrogenic miR at the single-cell level, revealing differences in miR concentration between the near-nucleus region and the main cytosol.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
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Multidisciplinary Sciences
Eyal Stein et al.
Summary: This study demonstrates a simple and tunable approach for fabricating ambipolar organic electrochemical transistors (OECTs) and circuits by judicious selection of p- and n-type materials for blend-based organic mixed ionic-electronic conductors (OMIECs). These ambipolar OECTs exhibit high transconductance, excellent stability, and high gains, providing a new paradigm for the fabrication of ambipolar OMIECs and circuits with little constraints on materials design and synthesis.
NATURE COMMUNICATIONS
(2022)
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Meng-Jiao Lu et al.
Summary: This work demonstrates the biological tuning of surface charge for an organic photo-electrochemical transistor (OPECT) biosensor. By manipulating the disassembly of DNA concatemers, the effective gate voltage and transfer characteristics of the OPECT can be significantly improved with enhanced resolution. The opto-bioelectronic device presented in this study converts events of charged molecules into amplified electrical signals and provides a generic platform for studying biological tunability and light-biomatter interplay.
Article
Chemistry, Multidisciplinary
Pushpa R. Paudel et al.
Summary: The study revised current scaling laws, taking into account ion drift and diffusion, and revealed that the maximum transconductance of OECTs is found at the transition between the depletion and accumulation region of the transistor, providing an explanation for the observed transconductance peak shift.
ADVANCED FUNCTIONAL MATERIALS
(2021)
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Chemistry, Analytical
Ying Fu et al.
Summary: Analyzing ribonucleic acid (RNA) is crucial for early disease diagnosis, and a portable biosensing platform based on disposable organic electrochemical transistors has been developed for ultra-sensitive analysis of microRNA (miRNA) biomarkers within 1 hour. The technology allows for fast and highly selective detection of RNA biomarkers, offering potential for low-cost mobile diagnosis of various diseases.
ANALYTICAL CHEMISTRY
(2021)
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Yi-Fan Ruan et al.
Summary: A dual-functional photocathodic single-cell nanotool has been developed for direct intracellular drug delivery and evaluation of oxidative stress, pushing the boundary of current single-cell electroanalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Dimitra Athanasiadou et al.
Summary: DNA serves as a promising scaffold for guiding biomineralization, with DNA nanostructures templating calcium-based and silica biominerals. Through molecular recognition in DNA nanotechnology, controllable 1D, 2D, and 3D nanostructures can be formed, making them attractive templates for the synthesis of mineralized tissues.
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(2021)
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Siew Ting Melissa Tan et al.
Summary: Organic electrochemical transistors (OECTs) have shown promising performance as transducers and amplifiers of low potentials due to their exceptional transconductance enabled by the volumetric charging of organic mixed ionic/electronic conductors (OMIECs). However, current approaches that directly conduct chemical reactions within the OECT electrolyte do not fully leverage the OECT's large transconductance, resulting in sub-unity transduction of gate to drain current. This study presents an alternative device architecture that separates chemical transduction and amplification processes to achieve high-gain chemical OECT transducers.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
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Arun Richard Chandrasekaran
Summary: DNA nanotechnology has advanced from structural design to application-oriented research, facing challenges such as susceptibility to nuclease attack in biological applications. Recent strategies have been developed to enhance nuclease resistance of DNA nanostructures, with studies focusing on stability in biological fluids.
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Matthew D. Newton et al.
Summary: The study demonstrates that the dinuclear ruthenium(II) complex can thread and lock into force-extended DNA in a two-step mechanism, with one stereoisomer showing the highest binding affinity reported. Interestingly, the complex behaves differently on torsionally constrained DNA and negatively supercoiled DNA, making it a potential long-lived luminescent label for biological applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Hong Liu et al.
Summary: A rapid, low-cost, and portable SARS-CoV-2 IgG detection platform based on OECTs was reported, with remote control via mobile phone. By optimizing ion concentrations and pH values, specific detection of the virus was achieved in minutes, showing promise in the diagnosis and prognosis of COVID-19.
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Yongheng Wang et al.
Summary: Nanoparticles releasing an oxaliplatin prodrug and a cationic DNA intercalator within temozolomide-resistant gliomas inhibit tumor growth without causing detectable toxicity. Combining anticancer drugs with distinct mechanisms of action, selective drug release, and convection-enhanced delivery may represent a translational strategy for the treatment of TMZ-resistant gliomas.
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NATURE BIOMEDICAL ENGINEERING
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Angela F. De Fazio et al.
Summary: The self-assembly of inorganic nanoparticles into larger structures allows for the fabrication of novel materials with collective properties; recently developed methods for controlling nanoparticle organization have enabled the fabrication of new materials; DNA modifications and molecular intercalators have been utilized as tools for manipulating DNA-nanoparticle structures.
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