Variable fragmentation and ionization of amyloid-beta epimers and isomers

Review Chemistry, Multidisciplinary

Detection and analysis of chiral molecules as disease biomarkers

Yaoran Liu et al.

Summary: The chirality of small metabolic molecules plays an important role in physiological processes and health assessment. Abnormal ratios of enantiomers in biofluids and tissues are associated with various diseases. Chiral small molecules show great potential as biomarkers for disease diagnosis, prognosis, drug-effect monitoring, pharmacodynamics, and personalized medicine. However, analyzing small chiral molecules in clinical settings remains challenging due to their diversity and low concentration levels.

NATURE REVIEWS CHEMISTRY (2023)

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Article Multidisciplinary Sciences

Antibody binding of amyloid beta peptide epimers/isomers and ramifications for immunotherapies and drug development

Elizabeth R. Readel et al.

Summary: Extracellular deposition of amyloid beta (A beta) peptide contributes to Alzheimer's disease (AD). Efforts have been made to create effective antibodies targeting A beta peptides. Modified A beta peptides found in AD patients may affect the response of these immunotherapies. Immunoprecipitation was used to examine the binding affinity of antibodies against aberrant A beta peptides, while tandem mass spectrometry showed variable results for these peptides.

SCIENTIFIC REPORTS (2023)

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Article Physics, Atomic, Molecular & Chemical