Pursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level

In the era that we seek personalization in material things, it is becoming increasingly clear that the individualized management of medicine and nutrition plays a key role in life expectancy and quality of life, allowing participation to some extent in our welfare and the use of societal resources in a rationale and equitable way. The implementation of precision medicine and nutrition are highly complex challenges which depend on the development of new technologies able to meet important requirements in terms of cost, simplicity, and versatility, and to determine both individually and simultaneously, almost in real time and with the required sensitivity and reliability, molecular markers of different omics levels in biofluids extracted, secreted (either naturally or stimulated), or circulating in the body. Relying on representative and pioneering examples, this review article critically discusses recent advances driving the position of electrochemical bioplatforms as one of the winning horses for the implementation of suitable tools for advanced diagnostics, therapy, and precision nutrition. In addition to a critical overview of the state of the art, including groundbreaking applications and challenges ahead, the article concludes with a personal vision of the imminent roadmap.

Automated summary

In the era of personalization, personalized management of medicine and nutrition is crucial for life expectancy and quality of life. Implementing precision medicine and nutrition is a complex challenge that requires new technologies to meet cost, simplicity, and versatility requirements, as well as accurately determining molecular markers in biofluids at different omics levels almost in real time. This review critically discusses recent advances and positions electrochemical bioplatforms as suitable tools for advanced diagnostics, therapy, and precision nutrition.