Always enough but never too much: the how and why of downregulating tissue oxygenation

Review Physiology

Acute oxygen sensing by vascular smooth muscle cells

Alejandro Moreno-Dominguez et al.

Summary: An adequate supply of oxygen is crucial for life forms on earth, and when oxygen levels are low, the body produces adaptive reflexes to increase oxygen uptake and distribution to tissues. This paper analyzes the vasomotor responses to hypoxia, specifically hypoxic pulmonary vasoconstriction and hypoxic vasodilation, which help regulate blood flow in the lungs and systemic arteries. Arterial smooth muscle cells contain an acute O-2 sensing system that detects changes in oxygen levels and regulates contraction. The article summarizes current knowledge on oxygen sensing and signaling systems in acute vasomotor responses to hypoxia and discusses the similarities and differences in different arterial territories.

FRONTIERS IN PHYSIOLOGY (2023)

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Review Physiology

THE ROLE OF GLOBINS IN CARDIOVASCULAR PHYSIOLOGY

T. C. Stevenson Keller et al.

Summary: Globin proteins exist in various cell types of the vasculature and have the ability to interact with molecular oxygen and nitric oxide. They play important roles in regulating vascular contraction, tissue perfusion, and vascular reactivity. Understanding the impact of globin proteins on vascular physiology is of great significance for further research on their functions.

PHYSIOLOGICAL REVIEWS (2022)

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Article Endocrinology & Metabolism

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

Michael P. Murphy et al.

Summary: This article discusses the important roles of reactive oxygen species (ROS) in health and disease, and proposes guidelines and best practices for the nomenclature and assessment of ROS, oxidative reactions, and oxidative damage in cells, tissues, and in vivo.

NATURE METABOLISM (2022)

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Review Biochemistry & Molecular Biology

Oxidative eustress: On constant alert for redox homeostasis

Helmut Sies

Summary: The spatiotemporal control of redox signaling in cells relies on continuous fine-tuning, with molecules like H2O2 playing a key role. Oxidative eustress operates within a specific physiological range, and is managed through both short-term and long-term homeostatic mechanisms to respond to stress.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology