☆ 4.6 Review

The cardiovascular subtleties of testosterone on gender-affirming hormone therapy

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Peripheral Vascular Disease

Hypertension in transgender individuals

Michael S. Irwig

Summary: This article examines the prevalence rates of hypertension among transgender and gender-diverse populations. The findings suggest that a significant proportion of these populations are affected by hypertension. Routine monitoring of blood pressure is recommended, especially after the initiation of gender-affirming hormone therapy. Two large studies indicate that estrogen plus an antiandrogen is associated with a decrease in systolic blood pressure, while testosterone is associated with an increase in systolic blood pressure.

JOURNAL OF HUMAN HYPERTENSION (2023)

Add to Collection

Review Medicine, Research & Experimental

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Yvonne Baumer et al.

Summary: While it is known that social determinants can significantly impact cardiovascular health, the molecular mechanisms by which they lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes the biological effects of adverse social determinants, linking translational and laboratory studies with epidemiologic findings. The topics covered include biomarkers of chronic stress, the role of inflammation, immune cell distribution and characterization, and epigenetic regulation. The review highlights critical knowledge gaps and the need for targeted interventions to improve cardiometabolic health for at-risk populations.

CLINICAL SCIENCE (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

When it's time for the sex talk, words matter

Austin T. Robinson et al.

Summary: The traditional assumption in biomedical research studies that young, healthy white males are the default human has faced increasing scrutiny and criticism. The underrepresentation of women in biomedical research has been recognized and addressed, with a current call for papers on the topic. This article discusses the terminology (man/woman vs. male/female) for human research participants when considering sex as a biological variable, emphasizing the importance of gender identity to overall health. Though the authors may have differing views on terminology, they all agree on the importance of including biological sex in research studies.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

Add to Collection

Article Cell Biology

Testosterone and dihydrotestosterone modulate the redox homeostasis of endothelium

George N. Koukoulis et al.

Summary: The study found that testosterone and dihydrotestosterone increase oxidative stress and inflammation in endothelial cells, leading to increased nitric oxide synthesis and decreased antioxidant enzyme activity. These findings help explain the effects of testosterone on the cardiovascular system.

CELL BIOLOGY INTERNATIONAL (2022)

Add to Collection

Article Pediatrics

Weight Status, Medication Use, and Recreational Activities of Treatment-Naive Transgender Youth

Mirae J. Fornander et al.

Summary: Studies of transgender/gender diverse (TGD) youth show a high prevalence of overweight/obesity, with female sex assigned at birth (SAB) participants having higher BMIz values. Watching/listening to media and parent-reported creative arts involvement were associated with higher BMIz, while spending time with friends and family was associated with lower BMIz.

CHILDHOOD OBESITY (2022)

Add to Collection

Article Immunology

The Imbalance in Th17 and Treg Cells in Polycystic Ovarian Syndrome Patients with Autoimmune Thyroiditis

Ming Ma et al.

Summary: The study revealed that the ratio of Th17/Treg cells and the expression of Th17-related factors were significantly higher in PCOS-AIT patients. Testosterone treatment led to decreased Th17 cell proportion and increased Treg cell proportion in CD4(+) T cells from PCOS-AIT patients, suggesting a therapeutic potential in targeting the Th17/Treg cell axis for the treatment of PCOS-AIT.

IMMUNOLOGICAL INVESTIGATIONS (2022)

Add to Collection

Article Psychology, Clinical

Assigned-Female-at-Birth Trans Masculine and Non-Binary Individuals Differ in Their Body Satisfaction and Desire for Gender Affirming Treatments

Catherine Schaeff

Summary: Non-binary individuals are less likely to physically affirm their gender, suggesting less need for body modifications. Some non-binary individuals use gender affirming treatments to defeminize rather than masculinize their bodies.

ARCHIVES OF SEXUAL BEHAVIOR (2022)

Add to Collection

Article Nursing

Initiation of Gender-Affirming Testosterone Therapy in a Lactating Transgender Man

Sara Oberhelman-Eaton et al.

Summary: The study investigated a 30-year-old transgender lactating man who self-administered subcutaneous testosterone when initiating gender-affirming therapy. The results showed no observable side effects on the infant's safety and health during the study period.

JOURNAL OF HUMAN LACTATION (2022)

Add to Collection

Article Biology

Specialized androgen synthesis in skeletal muscles that actuate elaborate social displays

Eric R. Schuppe et al.

Summary: Androgens play a crucial role in mediating reproductive behaviors, including elaborate displays used in courtship and territorial interactions. This study found that certain bird species can produce androgens locally in their muscles to support their social and sexual displays, even when testosterone levels are low in the bloodstream. In mammals, however, the capacity for de novo synthesis of androgens seems to be limited to superfast muscles. This research reveals an important dimension of androgen regulation in behavior.

JOURNAL OF EXPERIMENTAL BIOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women

Kirstie A. De Jong et al.

Summary: This study investigated the left ventricular geometric patterns in obese women with polycystic ovary syndrome (PCOS). The results suggest that obese women with PCOS are more likely to develop concentric hypertrophy of the left ventricle compared to obese women without PCOS. This calls for additional cardiovascular risk assessment in normotensive obese women with PCOS.

PLOS ONE (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Hormones and Sex-Specific Medicine in Human Physiopathology

Maria Raza Tokatli et al.

Summary: This article provides a broad review of the role of hormone regulation in gender medicine and gender differences across key clinical areas. The study highlights the influence of sex differences in immune response, cardiovascular diseases, neurological disorders, cancer, and COVID-19. It also emphasizes the importance of gender implications in occupational health and health policy, calling for more personalized clinical medicine and public health approaches.

BIOMOLECULES (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Evaluation of the Interaction of Sex Hormones and Cardiovascular Function and Health

Myrthe M. A. Willemars et al.

Summary: The effects of sex hormones on the cardiovascular system are poorly understood. Recent studies have revealed the association between sex hormones and cardiovascular diseases, as well as the different symptoms and progression in men and women. Abnormal levels of sex hormones pose an independent risk for cardiovascular diseases, and hormone-based therapies may not be beneficial for cardiovascular health.

CURRENT HEART FAILURE REPORTS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Th17 cell-linked mechanisms mediate vascular dysfunction induced by testosterone in a mouse model of gender-affirming hormone therapy

Jeimison D. Santos et al.

Summary: This study found that testosterone can cause cardiovascular dysfunction in females by enhancing Th17 cell-related mechanisms, leading to increased blood pressure. Furthermore, changes in immune-cell balance may play a crucial role in gender-affirming hormone therapy (GAHT) in transmasculine individuals.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Sex differences in arterial hypertension A scientific statement from the ESC Council on Hypertension, the European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professions, the ESC Council for Cardiology Practice, and the ESC Working Group on Cardiovascular Pharmacotherapy

Eva Gerdts et al.

Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.

EUROPEAN HEART JOURNAL (2022)

Add to Collection

Article Endocrinology & Metabolism

The effects of testosterone on transgender males on carotid intima-media thickness and serum inflammatory markers compared within patients with polycystic ovary syndrome

Ayse Ozlem Balik et al.

Summary: This study evaluated the effects of testosterone on carotid intima-media thickness (CIMT) and serum inflammatory markers in transgender males (TGM) and polycystic ovary syndrome (PCOS). It found that CIMT was significantly higher in TGM individuals compared to PCOS and controls, but not associated with inflammation. This suggests that increased CIMT may be a deleterious effect of exogenous testosterone exposure. Regular clinical and radiological evaluation is recommended for these individuals.

GYNECOLOGICAL ENDOCRINOLOGY (2022)

Add to Collection

Article Psychology, Clinical

Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

E. Coleman et al.

Summary: This study introduces the latest developments in transgender healthcare and the role of the World Professional Association for Transgender Health (WPATH) and its Standards of Care (SOC). SOC-8 is a new set of guidelines for transgender healthcare, aiming to provide healthcare professionals with clinical guidance to assist transgender and gender diverse (TGD) individuals in achieving comfort and overall health. The guidelines are based on the best available science and expert consensus, and recommendations were developed through systematic literature reviews and expert opinions.

INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH (2022)

Add to Collection

Article Physiology

Impact of sex and sex hormones on pathophysiology and progression of aortic stenosis in a murine model

Marie-Ange Fleury et al.

Summary: This study found that sex-specific differences play an important role in the pathophysiology of AS. Women with AS present extensive fibrotic remodeling, while men develop more calcification deposit. Male sex and testosterone play a significant role in upregulating pro-calcifying genes and hemodynamic progression of AS. On the other hand, female mice appear to be protected against calcification, characterized by downregulation of pro-osteogenic genes, but show similar AS hemodynamic progression.

PHYSIOLOGICAL REPORTS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Biventricular dysfunction and lung congestion in athletes on anabolic androgenic steroids: a speckle tracking and stress lung echocardiography analysis

Antonello D'Andrea et al.

Summary: In athletes abusing steroids, speckle tracking echocardiography analysis revealed impaired right ventricular systolic deformation, closely associated with reduced functional capacity during physical effort, and more pulmonary congestion during exercise.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

Add to Collection

Article Obstetrics & Gynecology

Testosterone administration increases leukocyte-endothelium interactions and inflammation in transgender men

Francesca Iannantuoni et al.

Summary: Testosterone treatment in transgender men increases leukocyte-endothelium interactions and levels of adhesion molecules and proinflammatory cytokines, indicating the necessity to monitor cardiovascular risk in these patients.

FERTILITY AND STERILITY (2021)

Add to Collection

Review Peripheral Vascular Disease

Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review

Paul J. Connelly et al.

Summary: Limited studies suggest that transgender men undergoing gender-affirming hormone therapy typically do not experience significant changes in blood pressure; while blood pressure in transgender women may show trends of increase or decrease. However, the current research is characterized by significant methodological limitations and insufficient quality.

JOURNAL OF HYPERTENSION (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

The effect of transgender hormonal treatment on high density lipoprotein cholesterol efflux capacity

Daan M. van Velzen et al.

Summary: Total HDL-CEC decreased during HT in trans women, with a specific reduction in ABCA1 CEC. This finding might contribute to a higher CVD risk.

ATHEROSCLEROSIS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Cross-sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure

Debora Conte Kimura Lichtenecker et al.

Summary: The study found that female rats undergoing testosterone therapy had changes in renal morphology and function, including increased kidney weight, decreased urine osmolarity, reduced glomerular filtration rate, larger glomerular area, and higher systolic blood pressure. This suggests that testosterone therapy in female rats may lead to adaptations similar to those observed in transmen on long-term testosterone therapy.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2021)

Add to Collection

Article Reproductive Biology

Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats

Jay S. Mishra et al.

Summary: Preeclampsia and testosterone-induced gestational hypertension models show upregulation of AT(1)R and downregulation of AT(2)R, increasing AT(2)R activity could help restore the balance between AT(1)R and AT(2)R and improve gestational vascular function.

BIOLOGY OF REPRODUCTION (2021)

Add to Collection

Article Neurosciences

Sex neurosteroids: Hormones made by the brain for the brain

L. Fester et al.

Summary: Hippocampal neurons have the ability to synthesize sex steroids from cholesterol, with estradiol and testosterone playing important roles in maintaining synaptic transmission and connectivity. The synthesis of these steroids is regulated by internal and external factors, and there are sex-specific differences in how estradiol and dihydrotestosterone affect synaptic functions. The link between GnRH-induced estradiol synthesis and cyclical changes in spine density in the female hippocampus suggests a complex interaction between the hypothalamus and hippocampus in regulating neuronal responses to sex neurosteroids.

NEUROSCIENCE LETTERS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Health disparities: Intracellular consequences of social determinants of health

Rebecca T. Emeny et al.

Summary: Health disparities are influenced by exposures to socioeconomic status, living conditions, race/ethnicity, diet, and environmental pollutants. These exposures make up a person's exposome, also known as social determinants of health (SDOH), which have a greater impact on health than health care. Intracellular redox rheostats are modulated by the SDOH-exposome, as well as genetic predisposition and age, leading to chronic inflammation and immunosenescence, affecting various diseases.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Add to Collection

Review Peripheral Vascular Disease

Social Determinants of Health and Cardiovascular Disease: Current State and Future Directions Towards Healthcare Equity

Mohammad Hashim Jilani et al.

Summary: Social determinants of health have a significant impact on cardiovascular health and contribute to disparities in risk factors and outcomes of cardiovascular disease. Favorable social conditions have protective effects on cardiovascular health, while unfavorable social conditions are associated with higher burden of risk factors and poor outcomes.

CURRENT ATHEROSCLEROSIS REPORTS (2021)

Add to Collection

Article Peripheral Vascular Disease

Blood Pressure Effects of Gender-Affirming Hormone Therapy in Transgender and Gender-Diverse Adults

Katherine Banks et al.

Summary: This study found that after starting gender-affirming hormone therapy, systolic blood pressure decreased in the transfeminine group and increased in the transmasculine group, with these changes maintained throughout the follow-up period. The prevalence of stage 2 hypertension decreased by 47% in the transfeminine group within 2 to 4 months of GAHT initiation. Further research is needed to explore the effects of GAHT in older gender-diverse individuals and optimal formulations of GAHT.

HYPERTENSION (2021)

Add to Collection

Article Urology & Nephrology

Long-Term Gender-Affirming Hormone Therapy and Cognitive Functioning in Older Transgender Women Compared With Cisgender Women and Men

Jason O. van Heesewijk et al.

Summary: Long-term gender-affirming hormone therapy in older transgender women may have beneficial effects on cognitive functioning. This study found that transgender women performed similarly to cisgender men in most cognitive tests, with cardiovascular and psychological factors partly explaining differences in MMSE scores between transgender women and cisgender control groups. The study suggests that long-term GHT effects on cognitive functioning in older transgender women are minimal.

JOURNAL OF SEXUAL MEDICINE (2021)

Add to Collection

Article Cell Biology

Cardiovascular Properties of the Androgen-Induced PCOS Model in Rats: The Role of Oxidative Stress

Jovana Joksimovic Jovic et al.

Summary: PCOS affects the heart mainly through changes in cardiodynamic parameters, blood pressure, and cardiac tissue morphology, with oxidative stress potentially being a contributing factor to the development of cardiovascular risk in women with PCOS.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Article Health Care Sciences & Services

Propensity Score Analysis Assessing the Burden of Non-Communicable Diseases among the Transgender Population in the United States Using the Behavioral Risk Factor Surveillance System (2017-2019)

Jennifer R. Pharr et al.

Summary: Research prioritizing the assessment of non-communicable diseases burden among transgender individuals revealed that they are more likely to suffer from chronic conditions and risk factors compared to cisgender individuals, including hypertension, hypercholesteremia, prediabetes, depression, and other cardiovascular and metabolic disorders. These findings highlight the need for health equity models to address the disparities observed among transgender populations.

HEALTHCARE (2021)

Add to Collection

Article Obstetrics & Gynecology

Short-term testosterone use in female mice does not impair fertilizability of eggs: implications for the fertility care of transgender males

C. B. Bartels et al.

Summary: The study showed that testosterone injections in female mice caused virilization, but ovaries were still able to produce fertilizable eggs. This research provides insights for future clinical trials on fertility treatment options for transgender men.

HUMAN REPRODUCTION (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

Maria Manti et al.

CARDIOVASCULAR RESEARCH (2020)

Add to Collection

Article Endocrinology & Metabolism

Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth

Natalie J. Nokoff et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

Gender Differences in Cardiac Hypertrophy

Jian Wu et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2020)

Add to Collection

Article Obstetrics & Gynecology

Parental desire and fertility preservation in assigned female at birth transgender people living in Belgium

Justine Defreyne et al.

FERTILITY AND STERILITY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association

Salim S. Virani et al.

CIRCULATION (2020)

Add to Collection

Article Endocrinology & Metabolism

Compromised endothelial function in transgender men taking testosterone

Barbara I. Gulanski et al.

CLINICAL ENDOCRINOLOGY (2020)

Add to Collection

Article Pediatrics

Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents

Maartje Klaver et al.

PEDIATRICS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Modulation of Vascular Function by Perivascular Adipose Tissue: Sex Differences

Jamaira A. Victorio et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Add to Collection

Article Immunology

Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome

Juliano Vilela Alves et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Biology

Testosterone aggravates cerebral vascular injury by reducing plasma HDL levels

Tao Jin et al.

OPEN LIFE SCIENCES (2020)

Add to Collection

Review Public, Environmental & Occupational Health

Health of transgender men in low-income and middle-income countries: a scoping review

Ayden Scheim et al.

BMJ GLOBAL HEALTH (2020)

Add to Collection

Review Pharmacology & Pharmacy

Hypertension: a new treatment for an old disease? Targeting the immune system

Gisele Facholi Bomfim et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes

Min Hou et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Cardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population

Talal Alzahrani et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2019)

Add to Collection

Article Endocrinology & Metabolism

Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome is not related to insulin or LH

Saad A. Amer et al.

JOURNAL OF ENDOCRINOLOGY (2019)

Add to Collection

Review Endocrinology & Metabolism

Size and Distribution of Transgender and Gender Nonconforming Populations A Narrative Review

Michael Goodman et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2019)

Add to Collection

Review Endocrinology & Metabolism

The endocrine function of adipose tissues in health and cardiometabolic disease

Ludger Scheja et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Add to Collection

Article Obstetrics & Gynecology

A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men

H. M. Kinnear et al.

HUMAN REPRODUCTION (2019)

Add to Collection

Review Endocrinology & Metabolism

Endocrinology of Transgender Medicine

Guy T'Sjoen et al.

ENDOCRINE REVIEWS (2019)

Add to Collection

Article Endocrinology & Metabolism

Cardiometabolic Effects of Testosterone in Transmen and Estrogen Plus Cyproterone Acetate in Transwomen

Daan M. van Velzen et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Add to Collection

Review Physiology

SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux

Wen-Jun Shen et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Add to Collection

Article Physiology

Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension

Tiago J. Costa et al.

FRONTIERS IN PHYSIOLOGY (2018)

Add to Collection

Article Medicine, Research & Experimental

Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study

Anna Wiik et al.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2018)

Add to Collection

Article Endocrinology & Metabolism

Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE-/- Mice

Laura G. Goetz et al.

ENDOCRINOLOGY (2018)

Add to Collection

Article Endocrinology & Metabolism

Health and Cardiometabolic Disease in Transgender Adults in the United States: Behavioral Risk Factor Surveillance System 2015

Natalie J. Nokoff et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2018)

Add to Collection

Article Andrology

Cross-sex hormone therapy in transgender persons affects total body weight, body fat and lean body mass: a meta-analysis

M. Klaver et al.

ANDROLOGIA (2017)

Add to Collection

Review Neurosciences

Understanding the Broad Influence of Sex Hormones and Sex Differences in the Brain

Bruce S. McEwen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Add to Collection

Article Peripheral Vascular Disease

Role of Kidneys in Sex Differences in Angiotensin II-Induced Hypertension

Lei Wang et al.

HYPERTENSION (2017)

Add to Collection

Article Medicine, General & Internal

Surgical and pharmacological reassignment: influence on transsexual cardiovascular risk profile

Marco M. Ciccone et al.

INTERNAL MEDICINE JOURNAL (2017)

Add to Collection

Article Endocrinology & Metabolism

Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients

Daniel I. Spratt et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Add to Collection

Review Endocrinology & Metabolism

Sex Steroids and Cardiovascular Outcomes in Transgender Individuals: A Systematic Review and Meta-Analysis

Spyridoula Maraka et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Add to Collection

Article Endocrinology & Metabolism

Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline

Wylie C. Hembree et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Add to Collection

Review Physiology

ROLE OF THE IMMUNE SYSTEM IN HYPERTENSION

Bernardo Rodriguez-Iturbe et al.

PHYSIOLOGICAL REVIEWS (2017)

Add to Collection

Review Andrology

Effects of testosterone therapy on BMI, blood pressure, and laboratory profile of transgender men: a systematic review

I. Velho et al.

ANDROLOGY (2017)

Add to Collection

Review Endocrinology & Metabolism

Testosterone therapy for transgender men

Michael S. Irwig

LANCET DIABETES & ENDOCRINOLOGY (2017)

Add to Collection

Article Endocrinology & Metabolism

Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture

Laura G. Goetz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

Add to Collection

Review Pharmacology & Pharmacy

Perivascular adipose tissue inflammation in vascular disease

Ryszard Nosalski et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Add to Collection

Review Medicine, Research & Experimental

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

Angela K. Lucas-Herald et al.

CLINICAL SCIENCE (2017)

Add to Collection

Article Cardiac & Cardiovascular Systems

Effect of resveratrol and orchidectomy on the vasorelaxing influence of perivascular adipose tissue

Charlotte Boydens et al.

HEART AND VESSELS (2016)

Add to Collection

Review Physiology

Reactive oxygen species: players in the cardiovascular effects of testosterone

Rita C. Tostes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2016)

Add to Collection

Article Reproductive Biology

Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure in Adult Female Rats

Amar S. More et al.

BIOLOGY OF REPRODUCTION (2016)

Add to Collection

Article Endocrinology & Metabolism

Supra-physiological dose of testosterone induces pathological cardiac hypertrophy

Prapawadee Pirompol et al.

JOURNAL OF ENDOCRINOLOGY (2016)

Add to Collection

Article Peripheral Vascular Disease

Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta

Jay S. Mishra et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2016)

Add to Collection

Article Surgery

Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation

John P. Davis et al.

JOURNAL OF VASCULAR SURGERY (2016)

Add to Collection

Article Audiology & Speech-Language Pathology

Effects on Voice Fundamental Frequency and Satisfaction with Voice in Trans Men during Testosterone Treatment-A Longitudinal Study

Ulrika Nygren et al.

JOURNAL OF VOICE (2016)

Add to Collection

Article Medicine, General & Internal

Transgender people: health at the margins of society

Sam Winter et al.

LANCET (2016)

Add to Collection

Article Multidisciplinary Sciences

Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification

Dongxing Zhu et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Physiology

20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats

Carolina Dalmasso et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Association of testosterone with estrogen abolishes the beneficial effects of estrogen treatment by increasing ROS generation in aorta endothelial cells

Tiago J. Costa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Add to Collection

Article Physiology

Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats

Rodrigo Maranon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)

Add to Collection

Article Medicine, Research & Experimental

Testosterone induces leucocyte migration by NADPH oxidase-driven ROS- and COX2-dependent mechanisms

Andreia Z. Chignalia et al.

CLINICAL SCIENCE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice

Johan B. Fagman et al.

FASEB JOURNAL (2015)

Add to Collection

Article Psychiatry

Concomitant psychiatric problems and hormonal treatment induced metabolic syndrome in gender dysphoria individuals: A 2 year follow-up study

Marco Colizzi et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2015)

Add to Collection

Article Endocrinology & Metabolism

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

Danish Saleheen et al.

LANCET DIABETES & ENDOCRINOLOGY (2015)

Add to Collection

Article Physiology

Neural Control of the Circulation: How Sex and Age Differences Interact in Humans

Michael J. Joyner et al.

COMPREHENSIVE PHYSIOLOGY (2015)

Add to Collection

Article Peripheral Vascular Disease

Prenatal Testosterone Exposure Induces Hypertension in Adult Females via Androgen Receptor-Dependent Protein Kinase Cδ-Mediated Mechanism

Chellakkan S. Blesson et al.

HYPERTENSION (2015)

Add to Collection

Article Psychology, Clinical

Testosterone Treatment and MMPI-2 Improvement in Transgender Men: A Prospective Controlled Study

Colton L. Keo-Meier et al.

JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY (2015)

Add to Collection

Article Endocrinology & Metabolism

Role of Androgens in Sex Differences in Cardiac Damage During Myocardial Infarction

Thi Y. L. Le et al.

ENDOCRINOLOGY (2014)

Add to Collection

Article Peripheral Vascular Disease

Elevated Testosterone Levels During Rat Pregnancy Cause Hypersensitivity to Angiotensin II and Attenuation of Endothelium-Dependent Vasodilation in Uterine Arteries

Vijayakumar Chinnathambi et al.

HYPERTENSION (2014)

Add to Collection

Article Urology & Nephrology

Cross-Sex Hormone Therapy in Trans Persons Is Safe and Effective at Short-Time Follow-Up: Results from the European Network for the Investigation of Gender Incongruence

Katrien Wierckx et al.

JOURNAL OF SEXUAL MEDICINE (2014)

Add to Collection

Article Urology & Nephrology

Short- and Long-Term Clinical Skin Effects of Testosterone Treatment in Trans Men

Katrien Wierckx et al.

JOURNAL OF SEXUAL MEDICINE (2014)

Add to Collection

Article Urology & Nephrology

Effects of Three Different Testosterone Formulations in Female-to-Male Transsexual Persons

Carla Pelusi et al.

JOURNAL OF SEXUAL MEDICINE (2014)

Add to Collection

Article Medicine, Research & Experimental

Voice in Female-To-Male Transsexual Persons After Long-Term Androgen Therapy

Marjan Cosyns et al.

LARYNGOSCOPE (2014)

Add to Collection

Article Obstetrics & Gynecology

Transgender Men Who Experienced Pregnancy After Female-to-Male Gender Transitioning

Alexis D. Light et al.

OBSTETRICS AND GYNECOLOGY (2014)

Add to Collection

Article Endocrinology & Metabolism

Transsexual patients' psychiatric comorbidity and positive effect of cross-sex hormonal treatment on mental health: Results from a longitudinal study

Marco Colizzi et al.

PSYCHONEUROENDOCRINOLOGY (2014)

Add to Collection

Review Endocrinology & Metabolism

Management of female- to- male transgender persons: medical and surgical management, life expectancy

Louis J. Gooren

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2014)

Add to Collection

Article Physiology

Adrenal Androgens and Androgen Precursors-Definition, Synthesis, Regulation and Physiologic Actions

Adina Turcu et al.

COMPREHENSIVE PHYSIOLOGY (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Sex hormones in the cardiovascular system

Roger Lyrio dos Santos et al.

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis

Zhenping Li et al.

CARDIOVASCULAR PATHOLOGY (2013)

Add to Collection

Article Peripheral Vascular Disease

The His and Hers of the Renin-Angiotensin System

Lucinda M. Hilliard et al.

CURRENT HYPERTENSION REPORTS (2013)

Add to Collection

Article Endocrinology & Metabolism

Prevalence of cardiovascular disease and cancer during cross-sex hormone therapy in a large cohort of trans persons: a case-control study

K. Wierckx et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)

Add to Collection

Article Urology & Nephrology

Effects of long-term high dose testosterone administration on vaginal epithelium structure and estrogen receptor-α and -β expression of young women

M. Baldassarre et al.

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2013)

Add to Collection

Article Sport Sciences

Impaired Post Exercise Heart Rate Recovery in Anabolic Steroid Users

M. R. dos Santos et al.

INTERNATIONAL JOURNAL OF SPORTS MEDICINE (2013)

Add to Collection

Article Physiology

Female spontaneously hypertensive rats have greater renal anti-inflammatory T lymphocyte infiltration than males

Ashlee J. Tipton et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2012)

Add to Collection

Review Pharmacology & Pharmacy

Sexual dimorphism in rodent models of hypertension and atherosclerosis

Kristen J. Bubb et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Add to Collection

Article Cardiac & Cardiovascular Systems

Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysms

Xuan Zhang et al.

CIRCULATION RESEARCH (2012)

Add to Collection

Review Endocrinology & Metabolism

The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?

Andrew Lansdown et al.

CLINICAL ENDOCRINOLOGY (2012)

Add to Collection

Article Endocrinology & Metabolism

Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder

Aya Nakamura et al.

ENDOCRINE JOURNAL (2012)

Add to Collection

Article Peripheral Vascular Disease

Testosterone Induces Vascular Smooth Muscle Cell Migration by NADPH Oxidase and c-Src-Dependent Pathways

Andreia Z. Chignalia et al.

HYPERTENSION (2012)

Add to Collection

Article Multidisciplinary Sciences

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way

Monan Angela Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Obstetrics & Gynecology

Fetal programming of adult hypertension in female rat offspring exposed to androgens in utero

K. Sathishkumar et al.

EARLY HUMAN DEVELOPMENT (2011)

Add to Collection

Article Endocrinology & Metabolism

A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones

Henk Asscheman et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2011)

Add to Collection

Article Medicine, General & Internal

Cardiovascular-Renal and Metabolic Characterization of a Rat Model of Polycystic Ovary Syndrome

Licy L. Yanes et al.

GENDER MEDICINE (2011)

Add to Collection

Article Endocrinology & Metabolism

Testosterone modulation of cardiac β-adrenergic signals in a rat model of heart failure

Junfeng Sun et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2011)

Add to Collection

Article Peripheral Vascular Disease

Androgen-Dependent Hypertension Is Mediated by 20-Hydroxy-5,8,11,14-Eicosatetraenoic Acid-Induced Vascular Dysfunction Role of Inhibitor of κB Kinase

Cheng-Chia Wu et al.

HYPERTENSION (2011)

Add to Collection

Letter Dermatology

Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone

WenChieh Chen et al.

EXPERIMENTAL DERMATOLOGY (2010)

Add to Collection

Article Obstetrics & Gynecology

The impact of testosterone administration to female-to-male transsexuals on insulin resistance and lipid parameters compared with women with polycystic ovary syndrome

Susanne Cupisti et al.

FERTILITY AND STERILITY (2010)

Add to Collection

Review Pharmacology & Pharmacy

Gender and the renin-angiotensin-aldosterone system

Kimiaki Komukai et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2010)

Add to Collection

Article Peripheral Vascular Disease

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans Role for Nitrite-Derived NO

Vikas Kapil et al.

HYPERTENSION (2010)

Add to Collection

Article Urology & Nephrology

Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals

Andreas Mueller et al.

JOURNAL OF SEXUAL MEDICINE (2010)

Add to Collection

Review Behavioral Sciences

Aldosterone: A forgotten mediator of the relationship between psychological stress and heart disease

Laura D. Kubzansky et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2010)

Add to Collection

Article Obstetrics & Gynecology

Histology of genital tract and breast tissue after long-term testosterone administration in a female-to-male transsexual population

Michael Grynberg et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2010)

Add to Collection

Article Endocrinology & Metabolism

Chronic anabolic androgenic steroid exposure alters corticotropin releasing factor expression and anxiety-like behaviors in the female mouse

Beth A. Costine et al.

PSYCHONEUROENDOCRINOLOGY (2010)

Add to Collection

Article Cardiac & Cardiovascular Systems

Sex differences and central protective effect of 17β-estradiol in the development of aldosterone/NaCl-induced hypertension

Baojian Xue et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Add to Collection

Article Endocrinology & Metabolism

Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals

J. W. Jacobeit et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2009)

Add to Collection

Article Toxicology

Doping and effects of anabolic androgenic steroids on the heart: histological, ultrastructural, and echocardiographic assessment in strength athletes

N. A. Hassan et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2009)

Add to Collection

Article Endocrinology & Metabolism

Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: Evidence for a biphasic effect at physiological and supra-physiological concentrations

K. O. Rowell et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2009)

Add to Collection

Article Peripheral Vascular Disease

Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats

Alexandre A. da Silva et al.

HYPERTENSION (2008)

Add to Collection

Article Obstetrics & Gynecology

Increased arterial stiffness in female-to-male transsexuals treated with androgen

Yayoi Emi et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2008)

Add to Collection

Article Endocrinology & Metabolism

Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals

Andreas Mueller et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Add to Collection

Article Urology & Nephrology

Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals

Jens W. Jacobeit et al.

JOURNAL OF SEXUAL MEDICINE (2007)

Add to Collection

Article Obstetrics & Gynecology

Association between polycystic ovary syndrome and female-to-make transsexuality

Tsuyoshi Baba et al.

HUMAN REPRODUCTION (2007)

Add to Collection

Article Peripheral Vascular Disease

Estrogen and hypertension

Muhammad S. Ashraf et al.

CURRENT HYPERTENSION REPORTS (2006)

Add to Collection

Article Cardiac & Cardiovascular Systems

Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function

MA Cavasin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Add to Collection

Article Endocrinology & Metabolism

The effects of the aromatase inhibitor anastrozole on bone metabolism and cardiovascular risk indices in ovariectomized, androgen-treated female-to-male transsexuals

MCM Bunck et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2006)

Add to Collection

Article Cardiac & Cardiovascular Systems

Testosterone augments endotoxin-mediated cerebrovascular inflammation in male rats

A Razmara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

Add to Collection

Article Endocrinology & Metabolism

Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-κB-dependent pathway

AK Death et al.

ENDOCRINOLOGY (2004)

Add to Collection

Article Peripheral Vascular Disease

Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity

LM Harrison-Bernard et al.

HYPERTENSION (2003)

Add to Collection

Article Cardiac & Cardiovascular Systems

Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure

MS Taylor et al.

CIRCULATION RESEARCH (2003)

Add to Collection

Article Endocrinology & Metabolism

The human kidney is a progesterone-metabolizing and androgen-producing organ

M Quinkler et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Add to Collection

Article Cardiac & Cardiovascular Systems

Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction

MA Cavasin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Testosterone up-regulates scavenger receptor B1 and stimulates cholesterol efflux from macrophages

C Langer et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Add to Collection

Review Cardiac & Cardiovascular Systems

Sex hormones and hypertension

RK Dubey et al.

CARDIOVASCULAR RESEARCH (2002)

Add to Collection

Review Physiology

Mechanisms of estrogen action

S Nilsson et al.

PHYSIOLOGICAL REVIEWS (2001)

Add to Collection

Article Multidisciplinary Sciences

Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase

L Nathan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Add to Collection

Article Cardiac & Cardiovascular Systems

Androgen receptor expression is greater in macrophages from male than from female donors - A sex difference with implications for atherogenesis

JA McCrohon et al.

CIRCULATION (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.