Trade-offs in safety study design decisions on teratogenic gadolinium effects

Summary: This study aimed to evaluate the association between prenatal magnetic resonance imaging exposure with and without gadolinium-based contrast agents and fetal and neonatal death and neonatal intensive care unit admission. The study found no significant difference in fetal and neonatal death rates between prenatal exposure to gadolinium-based contrast agents and non-gadolinium-based contrast agents. The study's findings provide reassurance about the safety of prenatal exposure to gadolinium-based contrast agents used in magnetic resonance imaging.