Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 160, Issue -, Pages 41-53Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.10.001
Keywords
Ageing; Mouse models; Delayed ageing; Accelerated ageing; Caloric restriction
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Funding
- COST (European Cooperation in Science and Technology)
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Ageing is a process that gradually increases the organism's vulnerability to death. It affects different biological pathways, and the underlying cellular mechanisms are complex. In view of the growing disease burden of ageing populations, increasing efforts are being invested in understanding the pathways and mechanisms of ageing. We review some mouse models commonly used in studies on ageing, highlight the advantages and disadvantages of the different strategies, and discuss their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, we discuss examples of models of delayed or accelerated ageing and their modulation by caloric restriction. (C) 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license.
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