Frontotemporal dementia: Past, present, and future

INTRODUCTIONThe history of frontotemporal dementia (FTD) is both old and new. This study explores its historical roots, dating back to the 19th century, while recognizes it as a distinct neurological entity only a few decades ago. METHODSThis qualitative study and literature review provides an overview of FTD's historical background, birth, evolution, and future directions. RESULTSRecognition of FTD was hindered by rigid perceptions of dementia, the division between neurology and psychiatry, reliance on IQ-based assessment, limited neuroimaging capabilities, and lack of pathological proof. Overcoming these barriers involved revisiting early pioneers' approaches, focusing on focal impairment, establishing non-Alzheimer's disease cohorts, fostering collaboration, and developing diagnostic criteria. Current gaps include the need for biology-oriented psychiatry education, biological biomarkers, and culturally sensitive, objective clinical instruments predicting underlying pathology. DISCUSSIONIndependent multidisciplinary centers are essential. The future of FTD lies in disease-modifying therapies, presenting new opportunities for healthcare professionals and researchers.

Automated summary

This study explores the historical roots of frontotemporal dementia (FTD), dating back to the 19th century, and recognizes it as a distinct neurological entity only a few decades ago. The methods include qualitative study and literature review, providing an overview of FTD's historical background, birth, evolution, and future directions. The results indicate that recognition of FTD was hindered by various factors such as rigid perceptions of dementia, division between neurology and psychiatry, limited neuroimaging capabilities, and lack of pathological proof.