Demographically-adjusted normative data among Latinos for the version 3 of the Alzheimer's Disease Centers' Neuropsychological Test Battery in the Uniform Data Set

INTRODUCTIONWe developed demographically-adjusted normative data for Spanish- and English-speaking Latinos on the Version 3.0 of the National Alzheimer's Coordinating Center Uniform Data Set Neuropsychological Battery (UDS3-NB). METHODSHealthy Latino adults (N = 437) age 50-94 (191 Spanish- and 246 English-speaking) enrolled in Alzheimer's Disease Research Centers completed the UDS3-NB in their preferred language. Normative data were developed via multiple linear regression models on UDS3-NB raw scores stratified by language group with terms for demographic characteristics (age, years of formal education, and sex). RESULTSYounger age and more years of education were associated with better performance on most tests in both language groups, with education being particularly influential on raw scores among Spanish-speakers. Sex effects varied across tests and language groups. DISCUSSIONThese normative data are a crucial step toward improving diagnostic accuracy of the UDS3-NB for neurocognitive disorders among Latinos in the United States and addressing disparities in Alzheimer's disease and related dementias. HighlightsWe developed normative data on the UDS3-NB for Latinos in the US ages 50-94.Younger age and more years of education were linked to better raw scores in several cognitive tests.Education was particularly influential on raw scores among Spanish-speakers.Sex effects varied across tests and between English- and Spanish-speaking Latinos.These normative data might improve diagnostic accuracy of the UDS3-NB among Latinos.

Automated summary

Researchers developed normative data for the National Alzheimer's Coordinating Center Uniform Data Set Neuropsychological Battery (UDS3-NB) for Latino individuals in the US. Younger age and higher education were associated with better cognitive test scores, especially among Spanish-speakers. Sex effects varied across tests and language groups. These data can improve the diagnostic accuracy of the UDS3-NB among Latinos.