A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease

Corticobasal syndrome is a clinical entity characterized by asymmetric akinetic rigidity and a variety of higher cortical dysfunction. Predicting background pathology of corticobasal syndrome is rather challenging; however, clinical and neuroimaging findings may provide a clue to its etiopathological origin. Visuospatial dysfunction of posterior cortical atrophy and logopenic-type language impairment indicate the presence of Alzheimer's disease-related pathology, and they provide useful information in distinguishing Alzheimer's disease from other types of corticobasal syndrome. Here we describe a case of corticobasal syndrome who showed characteristic visuospatial symptoms with imaging evidence of Alzheimer's disease supported by amyloid-PET and tau/astrogliosis-PET. Early, accurate diagnosis based on clinical features and predictable biomarkers is mandatory to the success of early intervention in corticobasal syndrome associated with Alzheimer's disease.

Automated summary

Corticobasal syndrome is characterized by asymmetric akinetic rigidity and higher cortical dysfunction. Predicting its pathology is challenging, but clinical and neuroimaging findings can provide clues. Visuospatial dysfunction and language impairment indicate Alzheimer's disease-related pathology, aiding in distinguishing it from other types. Early diagnosis based on clinical features and biomarkers is crucial for successful intervention in corticobasal syndrome associated with Alzheimer's disease.