4.6 Article

Dupilumab sustains efficacy in patients with moderate-to-severe type 2 asthma regardless of ICS dose

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

A systematic literature review of burden of illness in adults with uncontrolled moderate/severe asthma

Alexandrosz Czira et al.

Summary: This article provides a systematic review of the burden of moderate/severe uncontrolled asthma, including prevalence, clinical measures, health-related quality of life, and economic burden. It reveals that patients with uncontrolled asthma have poor lung function, substantial exacerbation burden, and impaired quality of life. The direct, indirect, and total costs associated with managing uncontrolled asthma are also significant.

RESPIRATORY MEDICINE (2022)

Article Critical Care Medicine

Long-term safety and efficacy of dupilumab in patients with moderate-to-severe asthma (TRAVERSE): an open-label extension study

Michael E. Wechsler et al.

Summary: The study assessed the long-term safety and efficacy of dupilumab in patients with moderate-to-severe asthma over 96 weeks of treatment. The findings demonstrated good safety and efficacy during the study period, supporting the long-term use of dupilumab in this patient population.

LANCET RESPIRATORY MEDICINE (2022)

Article Respiratory System

Current unmet needs and potential solutions to uncontrolled asthma

William W. Busse et al.

Summary: Asthma patients often have poor asthma control, which not only affects the patients themselves but also burdens society. Solutions such as shared decision-making, good patient-clinician communication, self-management, multidisciplinary education, and new technology may help improve asthma control.

EUROPEAN RESPIRATORY REVIEW (2022)

Article Cardiac & Cardiovascular Systems

Dupilumab efficacy in subgroups of type 2 asthma with high-dose inhaled corticosteroids at baseline

Arnaud Bourdin et al.

Summary: Dupilumab reduced severe exacerbations and improved lung function and asthma control in sub-groups of patients with type 2 asthma and high-dose ICS at baseline.

RESPIRATORY MEDICINE (2022)

Article Allergy

Dupilumab is effective in type 2-high asthma patients receiving high-dose inhaled corticosteroids at baseline

Arnaud Bourdin et al.

Summary: Dupilumab significantly reduced severe exacerbations and improved lung function and asthma control in patients with type 2-high asthma on high-dose ICS at baseline.

ALLERGY (2021)

Article Allergy

Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics

Lina Ronnebjerg et al.

Summary: The study found a higher prevalence of severe asthma, with patients typically exhibiting more symptoms, activity limitations, heart disease, and lower lung function. Despite these impairments, many individuals with severe asthma did not have regular contact with healthcare providers.

JOURNAL OF ASTHMA AND ALLERGY (2021)

Article Allergy

Real-World Assessment of Asthma Specialist Visits Among US Patients with Severe Asthma

Jessica F. Most et al.

Summary: According to recent data, less than half of U.S. patients with severe asthma receive specialist care, with the lowest rates observed in older patients and those with non-respiratory comorbidities. Specialist care was associated with a lower prevalence of asthma exacerbations and rescue inhaler use.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Review Allergy

Mechanisms of Dupilumab

Hani Harb et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2020)

Review Allergy

Phenotypes and endotypes of adult asthma: Moving toward precision medicine

Ravdeep Kaur et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Allergy

Oral corticosteroid exposure and adverse effects in asthmatic patients

Patrick W. Sullivan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Medicine, General & Internal

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Klaus F. Rabe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

Inhaled corticosteroids and asthma control in adult-onset asthma: 12-year follow-up study

Iida Vahatalo et al.

RESPIRATORY MEDICINE (2018)

Review Biotechnology & Applied Microbiology

Targeting key proximal drivers of type 2 inflammation in disease

Namita A. Gandhi et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Allergy

The prevalence of severe refractory asthma

Pieter-Paul W. Hekking et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Immunology

Type 2 inflammation in asthma - present in most, absent in many

John V. Fahy

NATURE REVIEWS IMMUNOLOGY (2015)

Article Respiratory System

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Article Multidisciplinary Sciences

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

Lynn E. Macdonald et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

Andrew J. Murphy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Allergy

The natural history of asthma

Charles E. Reed

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Measurement properties and interpretation of three shortened versions of the asthma control questionnaire

EF Juniper et al.

RESPIRATORY MEDICINE (2005)

Article Critical Care Medicine

Can guideline-defined asthma control be achieved? The gaining optimal asthma control study

ED Bateman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)