Chromatin-transcription interface: The secret of eternal youth?

In their recent study in Nature, Debes et al. report an increase in RNA polymerase II (Pol II)-mediated transcriptional elongation speed associated with chromatin remodeling during aging in four metazoan animals, two human cell lines, and human blood. Their findings might help us understand why we age through evolutionarily conserved essential processes, and open a window to the molecular and physiological mechanisms influencing healthspan, lifespan and/or longevity.

Automated summary

In their recent study published in Nature, Debes et al. discovered an increase in RNA polymerase II (Pol II)-mediated transcriptional elongation speed associated with chromatin remodeling during aging in various organisms. This finding provides insights into the evolutionary conserved processes underlying aging and sheds light on the molecular and physiological mechanisms that influence healthspan, lifespan, and longevity.