Traceless Directing Group Enabled One-Pot Regiospecific Synthesis of 2,3-Diaryl-4-Fluoropyrroles

We describe a traceless group directed one-pot regiospecific cycloaddition strategy to construct 4-fluorinated pyrroles, which showcased promising anti-inflammatory activity previously. By taking advantage of this protocol, a range of 4-fluoropyrroles which are inaccessible via previous methods can be obtained, and a tentative reaction mechanism was proposed based on observed intermediates.

Automated summary

We present a traceless group directed one-pot regiospecific cycloaddition strategy for the synthesis of 4-fluorinated pyrroles, which have shown promising anti-inflammatory activity in previous studies. This method allows the synthesis of a variety of 4-fluoropyrroles that were previously inaccessible, and a proposed reaction mechanism is based on observed intermediates.