Access to 2-Sulfonyl-4-arylphenols and 2,6-Bis-sulfonyl 5-Aryl-4-arylidene-2-cyclohexenones via Metal Triflates-Catalyzed Domino Cyclocondensation of 1,3-Bis-sulfonylacetones and 3-Arylacroleins

Herein, metal triflates-catalyzed one-pot domino cyclocondensation of 1,3-bis-sulfonylacetones and 3-arylacroleins via (3+3) or (3+2+1) annulation has been proposed to construct diversified 2-sulfonyl-4-arylphenols and 2,6-bis-sulfonyl 5-aryl-4-arylidene-2-cyclohexenones. In this effective reaction, C-C and C=C bonds are formed via a cascade process and 3-arylacrolein acts as a C3 and C1 synthon during the formation of a six-membered ring system under mild conditions. A plausible mechanism has been proposed and discussed. image

Automated summary

Herein, a metal triflates-catalyzed one-pot domino cyclocondensation reaction of 1,3-bis-sulfonylacetones and 3-arylacroleins via (3+3) or (3+2+1) annulation has been proposed to construct diversified 2-sulfonyl-4-arylphenols and 2,6-bis-sulfonyl 5-aryl-4-arylidene-2-cyclohexenones. In this efficient reaction, C-C and C=C bonds are formed through a cascade process, and 3-arylacrolein acts as a C3 and C1 synthon during the formation of a six-membered ring system under mild conditions. The plausible mechanism has been proposed and discussed.