Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202300708
Keywords
Nitrogen heterocycles; Homogeneous catalysis; Synthetic methods; Radical reactions; Cyclization
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A photoredox-promoted approach for the synthesis of [1,4]diazepino[1,7-a]indol-6(7H)-ones starting from N-indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method involves a cascade radical addition on C-C double bond followed by intramolecular cyclization at indole C2-position, resulting in the formation of two diastereomeric indole-fused 1,4-diazepinones characterized by a N-C(aryl) axial chirality, with yields ranging from 51% to 99%.
A photoredox-promoted approach for the synthesis of [1,4]diazepino[1,7-a]indol-6(7H)-ones starting from N-indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C-C double bond followed by intramolecular cyclization at indole C2-position, affords two diastereomeric indole-fused 1,4-diazepinones characterized by a N-C(aryl) axial chirality in yields ranging from 51 to 99%.
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