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Mengzhen Wang et al.
Summary: Pyroptosis, a distinct mode of programmed cell death, differs significantly from apoptosis and cell necrosis. Mediated by the gasdermin protein, it leads to cellular outcomes such as swelling, membrane perforation, and release of cell contents. Recent research highlights the role of pyroptosis in disease etiology and progression, prompting scientists to explore ways to regulate pyroptosis pathways for disease management. However, there is a lack of research on the recent advancements in nanomaterials for modulating the pyroptosis pathway. This review article fills this gap by discussing the potential of nanomaterials in disease treatment through pyroptosis modulation and highlighting their mechanisms of action.
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Kaiyuan Liu et al.
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Xuya Yu et al.
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Jianquan Yang et al.
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Lei Li et al.
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Qingqing Zhang et al.
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He Wang et al.
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Lulu Zheng et al.
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ADVANCED FUNCTIONAL MATERIALS
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Ziyue Zu et al.
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ADVANCED FUNCTIONAL MATERIALS
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Wen Su et al.
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ADVANCED MATERIALS
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Meng-Jie Zhang et al.
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CHEMICAL COMMUNICATIONS
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Oncology
Xiangyi Kong et al.
Summary: Early detection and diagnosis of cancers are challenging, with late stage detection leading to high mortality rates. The development of novel and effective diagnosis and therapeutic methods for cancer treatments is crucial. Nanobots, as promising nanomedicine applications, have emerged as a forefront of multidisciplinary research. Progress in nanotechnology has enabled the assembly and deployment of functional molecular/nanosized machines, with nanobots increasingly utilized in cancer diagnosis and therapeutic treatment. This paper reviews the recent advancements of nanobots in cancer treatments, focusing on their fundamental features and applications in drug delivery, tumor sensing and diagnosis, targeted therapy, minimally invasive surgery, and comprehensive treatments. It also discusses the challenges and potential research opportunities of nanobots in revolutionizing cancer treatments. In the future, medical nanobots are expected to become more sophisticated and capable of performing multiple medical functions and tasks, becoming true nanosubmarines in the bloodstream.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
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Liang Zhang et al.
Summary: Covalent organic frameworks (COFs) have shown potential as porous materials for cancer phototherapy due to their unique characteristics. However, the aggregation-caused quenching effect and apoptosis resistance limit their effectiveness. This study demonstrated that linking AIEgens into COF networks was an effective strategy for inducing pyroptosis and enhancing antitumor immunity. The synergized system of AIE COF and αPD-1 effectively eradicated tumors and inhibited recurrence and metastasis in a tumor model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biotechnology & Applied Microbiology
Kamyar Hadian et al.
Summary: This article introduces the regulation of non-apoptotic cell death, such as necroptosis, pyroptosis, parthanatos, and ferroptosis, and provides an update on the development of small-molecule inhibitors targeting these pathways. Cell death is critical for the development and homeostasis of multicellular organisms, and dysregulation can lead to various diseases. Recent research has uncovered regulated forms of necrosis that are associated with degenerative diseases, inflammation, and cancer. Understanding these pathways offers new opportunities for therapeutic targeting.
NATURE REVIEWS DRUG DISCOVERY
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Yunxiu Zhang et al.
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ADVANCED MATERIALS
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Binbin Ding et al.
Summary: In this study, alkalescent sodium bicarbonate nanoparticles (NaHCO3 NPs) were prepared to neutralize lactic acid metabolism and activate cell death and immune pathways, leading to enhanced antitumor immunity and inhibition of tumor growth and metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Wenkai Lin et al.
Summary: Ir-HEcN is a metal complex decorated bacteria that targets tumor tissues and induces pyroptosis and immunogenic cell death of tumor cells under irradiation. It evokes anti-tumor immune responses and leads to the regression of solid tumors via enhanced photodynamic immunotherapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Guozheng Xing et al.
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Article
Engineering, Biomedical
Zhen Ya et al.
Summary: This study explored the feasibility of focused acoustic vortex (FAV)-mediated sonochemotherapy combined with immune checkpoint blockade (ICB) to reshape the immunosuppressive tumor microenvironment (TME) and potentiate systemic anti-tumor immunity. FAV-activated sonochemotherapy significantly enriched immunogenic cell death (ICD) inducers in tumors and amplified ICD of cancer cells compared to conventional focused ultrasound (FUS)-activated sonochemotherapy. This research provides a multifunctional strategy for enriching ICD inducers in tumors, amplifying ICD, and improving the immunosuppressive TME to enhance systemic anti-tumor immunity.
Article
Engineering, Biomedical
Yudi Deng et al.
Summary: Inducing pyroptosis in cancer cells can be achieved by delivering a drug complex to mitochondria, but the compensatory activation of mitophagy limits its anti-tumor effects. By inhibiting mitophagy, the pyroptosis can be intensified, leading to improved anti-tumor effects.
Article
Engineering, Biomedical
Zhenzhen Feng et al.
Summary: This study combines pyroptosis and augmented immunotherapy by designing an acid-responsive nanosystem. The system releases metal ions in response to the tumor microenvironment, initiating ROS-mediated pyroptosis. Additionally, the co-delivered immune adjuvant reverses the suppressive tumor immune microenvironment and induces inflammatory responses.
Article
Multidisciplinary Sciences
Liang Zhang et al.
Summary: This study presents a dual-inducer called COF-919, based on non-metallic AIEgen-based covalent organic frameworks, capable of triggering both pyroptosis and ferroptosis, resulting in enhanced anti-tumor immunity and inhibition of tumor growth and metastasis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Fengqiao Li et al.
Summary: This study reports a single-agent mRNA nanomedicine-based strategy that utilizes mRNA lipid nanoparticles (LNPs) encoding the N-terminus of gasdermin to trigger pyroptosis, eliciting robust antitumor immunity and sensitizing tumors to anti-PD-1 immunotherapy. The strategy turns cold tumors into hot ones and suppresses the growth of distant tumors, offering opportunities for cancer treatment.
NATURE COMMUNICATIONS
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Chemistry, Multidisciplinary
Yuheng Bao et al.
Summary: In this study, a highly efficient nitric oxide (NO) nanogenerator was developed by loading NO donor NMA into hyaluronic acid-modified hollow manganese dioxide nanoparticles. Under ultrasound irradiation, this nanogenerator can release Mn2+ at the tumor sites, leading to cascade tumor pyroptosis and cGAS-STING-based immunotherapy, effectively inhibiting tumor growth.
Review
Materials Science, Biomaterials
Zeyi Sun et al.
Summary: Metal-organic frameworks (MOFs) show great promise in biomedicine and nanomedicine. They are highly porous and easily modifiable, making them fascinating nanocarriers for drug delivery. The tailored components of MOFs can act as therapeutic agents, and their combinations can serve as carrier-free MOF-based nanodrugs. This review summarizes the advances in delivery systems and applications of nanoscale MOF-based materials as therapeutic agents, as well as discusses the challenges and future directions in the field of MOFs therapy.
JOURNAL OF MATERIALS CHEMISTRY B
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Binbin Ding et al.
Summary: By preparing alkaline sodium bicarbonate nanoparticles (NaHCO3 NPs), regulating lactic acid metabolism, and activating the pyroptosis pathway, it enhances immune responses and inhibits tumor growth and metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Kuikun Yang et al.
Summary: Nanomedicines, particularly polyprodrug nanomedicines, show promise in cancer therapies due to well-controlled composition and drug loading, presenting significant potential for combating tumors.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuxian Su et al.
Summary: The designed CA-Re photosensitizer can efficiently perform photodynamic therapy under hypoxic conditions and improve tumor immunogenicity through pyroptotic cell death, activating immune cells to ultimately eliminate tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Wang et al.
Summary: Gasdermin E (GSDME) is highly expressed in oral squamous cell carcinoma (OSCC) and is associated with better prognosis. Chemotherapy drugs can induce GSDME-mediated pyroptosis, and the loss of GSDME function attenuates the anti-tumor effect of cisplatin.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Chemistry, Physical
Junjie Zhou et al.
Summary: The study introduces a tumor-specific prodrug combining tanespimycin with chlorin e6 to induce pyroptosis in a targeted manner, enhancing the response to anti-PD-1 therapy and prolonging the survival of 4T1 breast tumor-bearing mice.
Review
Chemistry, Multidisciplinary
Lu-Lu Chen et al.
Summary: NIR-II imaging breakthrough imaging limitations in deep tissues, while NIR-II quantum dots exhibit excellent optical properties and have become promising fluorescent biomarkers in in vivo fluorescence imaging.
Review
Chemistry, Multidisciplinary
Jin Zhang et al.
Summary: This review discusses the use of stimuli-responsive nanoparticles (srNPs) in cancer immunotherapy, highlighting their potential to enhance anti-tumor immune responses by combining with tumor microenvironment and external stimuli. The goal is to achieve synergistic immunotherapy and long-term immune memory to prevent tumor recurrence.
Review
Oncology
Shuo Wang et al.
Summary: Research on the relationship between pyroptosis and cancer is gaining attention, with multiple strategies developed for inducing pyroptosis in cancer cells. However, there is currently no consensus on monitoring pyroptosis methods, indicating a need for further research in this area.
CANCER BIOLOGY & MEDICINE
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Article
Biotechnology & Applied Microbiology
Zhu Yu et al.
Summary: Sonodynamic therapy, utilizing ZIF-8 to encapsulate Ce6 and TPZ for targeted delivery, could induce pyroptosis of GC cells through ROS release and activation of TPZ, showing potential as a therapeutic method for cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Dan Li et al.
Summary: Polymeric vesicles, as promising drug delivery nanocarriers, have gained increasing attention in cancer therapy. This study provides a systematic review of various aspects of polymeric nanovesicles as drug delivery vectors for cancer treatment, including their characteristics, synthesis methods, and recent progress in antitumor drug delivery. The synergistic photothermal and imaging advantages of polymer nanovesicles contribute to improved anticancer effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
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Nanoscience & Nanotechnology
Weihong Guo et al.
Summary: In this study, VB12-sericin-PBLG-IR780 nanomicelles were successfully synthesized, which can induce pyroptosis through photothermal effect and promote DC maturation and activate antitumor immunity.
ACS APPLIED MATERIALS & INTERFACES
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Huizi Deng et al.
Summary: A combination treatment nanosystem based on chemodynamic therapy and photothermal therapy is developed for triggering ferroptosis and pyroptosis. The nanosystem shows promising cancer therapy effects and enhances immune response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yang Li et al.
Summary: Ion-interference therapy using ions to disrupt intracellular biological processes shows promise as a potential cancer treatment. In this study, NaCl nanocrystals were skillfully delivered to tumor cells and explosively released Na+/Cl- by using virus-mimicking and glutathione-responsive nanomaterials. This strategy effectively inhibited tumor growth by inducing cell swelling, reactive oxygen species generation, and depletion of glutathione.
Article
Chemistry, Multidisciplinary
Yao Liu et al.
Summary: In this study, an immunotherapy system based on red blood cell membrane encapsulated Listeria monacytagenes (Lmo@RBC) was developed to address the limitations of Lmo as a cancer vaccine. Lmo@RBC showed low systemic inflammatory response and enhanced accumulation in tumors, resulting in a strong and durable anti-tumor immune response with excellent therapeutic effects.
Review
Chemistry, Multidisciplinary
Jie Wang et al.
Summary: Cancer is a difficult-to-treat disease due to its high mortality rate and lack of effective diagnostic and treatment tools. Recent advancements in micro-/nanorobot technology provide opportunities for the development of cancer theragnostic platforms, which can enable precise drug delivery and improved permeation.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Penghao Ji et al.
Summary: Programmed cell death (PCD) plays a crucial role in combating tumors in the field of biomedicine. However, malignant tumor cells often develop resistance to commonly used anticancer drugs. A newly designed nanoassembly OA@IR820 targets mitochondria and releases ATP synthase inhibitor OA, leading to ATP synthesis inhibition and mitochondrial dysfunction, thereby promoting oxidative stress-mediated pyroptosis and offering a potential therapeutic strategy for malignant tumor treatment.
Article
Pharmacology & Pharmacy
Mingce Tian et al.
Summary: With the rapid development of nanotechnology, strategies related to nanomedicine have been utilized to overcome the drawbacks of traditional chemotherapy drugs, demonstrating potential for innovative drug delivery. Stimuli-responsive nanomaterials allow precise control of drug release and exhibit excellent specificity in response to various stimuli. Immunomodulators carried by nanomaterials can effectively regulate the immune system and enhance therapeutic effects on cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Yinan Ding et al.
Summary: Immunotherapy has emerged as a promising anticancer therapy, with the ability to activate immune cells, regulate the tumor immune microenvironment, and deliver drugs. Lipid nanovesicles as a drug delivery system have important applications in cancer immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qichao Yang et al.
Summary: A tumor microenvironment-activatable prodrug nanomicelle (PNM) was designed to trigger immunogenic pyroptosis and improve the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Xuan Wang et al.
Summary: Non-apoptotic cell death, such as ferroptosis, necroptosis, and pyroptosis, holds significant potential as an emerging cancer therapeutic target. Nanomedicine technology combined with different pathways and components can induce various forms of non-apoptotic cell death and achieve targeted and combination therapies.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Materials Science, Multidisciplinary
De-Run Chen et al.
Summary: Regulating the immunosuppressive status of the tumor immune microenvironment is challenging. Pyroptosis shows potential in tumor immune therapy by recruiting immune cells. This study designed a nanogel-based prodrug to reshape tumor immunity, resulting in increased immune cell numbers and improved response rate to anti-PD-1 therapy.
APPLIED MATERIALS TODAY
(2022)
Review
Chemistry, Medicinal
Linzhou Yin et al.
Summary: This article discusses the interplay between ferroptosis and tumor-related signaling pathways, and comprehensively summarizes the small-molecule compounds that may regulate cancer cell death by inducing ferroptosis, which will shed new light on the development of ferroptosis-related anticancer drugs in the future.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Haonan Li et al.
Summary: Monotherapy is not sufficient for clinical cancer treatment due to various challenges. Combinational cancer therapy has gained significance to overcome these challenges. Traditional combinatorial schemes using free drugs independently have issues such as diverse pharmacokinetics and biodistribution. To address these issues, carrier-free nanocombos based on self-assembling small-molecule prodrugs (SPNCs) have been developed, offering advantages like high drug loading and adjustable drug ratio with minimal toxicity.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Immunology
Sara Socorro Faria et al.
Summary: This article reviews the cellular and molecular mechanisms involved in inflammasome-mediated pyroptosis pathways in cancer cells. It discusses various therapeutic strategies against cancer, including immunotherapy, oncolytic virus therapy, and nanoparticle-based therapies, that can trigger and regulate pyroptosis cell death to reduce tumor growth and spread.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Chemistry, Multidisciplinary
Jiakang Jin et al.
Summary: This study explores the potential of targeting mitochondria to induce pyroptosis and enhance immunotherapy in osteosarcoma. The researchers synthesized a mitochondria-targeting polymer micelle and demonstrated its ability to induce immunogenic pyroptosis in osteosarcoma cells. Combination therapy with this micelle and an anti-PD-L1 antibody showed promising results in suppressing tumor proliferation and activating T cells.
Review
Biochemical Research Methods
Wiktoria Wilman et al.
Summary: Antibodies play a crucial role in therapeutics, and computational methods, including machine learning, are increasingly being used for antibody design and optimization. These methods offer improvements in structure prediction, antibody repertoire modeling, and generation of novel sequences.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Pharmacology & Pharmacy
Qiang Niu et al.
Summary: This study utilizes a new drug delivery system (Nig + DAC)@HmA to enhance pyroptosis through reinforced inflammation, leading to significant systemic antitumor immunity and impressive tumor suppression with negligible side effects.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Nanoscience & Nanotechnology
Jingqing Yao et al.
Summary: In this study, a controllable drug carrier, TMZ/Fe-TSL, was developed and shown to induce GBM cell death and promote ROS production when exposed to AMF. The way and mechanisms of cell death may involve ROS and pyroptosis.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Jing Liu et al.
Summary: This review summarizes the recent progress in PROTAC development targeting TME pathways and suggests potential directions for future PROTAC techniques as novel cancer treatment options.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Meng-Yun Liang et al.
Summary: The study developed a cascaded pH-activated supramolecular nanoprodrug (PDNP) that can effectively induce pyroptosis and enhance immune response through stepwise size shrinkage, combining with anti-PD-1 antibody to amplify tumor suppression.
Article
Biotechnology & Applied Microbiology
Xin Shen et al.
Summary: Periodontitis-associated bacteria may have the potential to inhibit the development of oral squamous cell carcinomas by regulating genome stability and modulating the DNA damage response and inflammatory pathways.
Article
Chemistry, Multidisciplinary
Bing Chen et al.
Summary: Metal-ion-based self-assembly supramolecular theranostics have great potential in biomedical applications, allowing for precise diagnosis, targeted drug delivery, and real-time therapy monitoring. This strategy opens up new research directions for developing novel drug delivery systems in cancer treatment.
FRONTIERS IN CHEMISTRY
(2022)
Review
Oncology
Hongxin Xie et al.
Summary: The biomedical application of metal-organic frameworks in cancer theranostics, specifically focusing on Zeolite Imidazole Framework-8 (ZIF-8), has gained significant attention due to its potential in cancer treatment and imaging. This review provides an update on recent discoveries and progress in the use of ZIF-8-based nanoplatforms for cancer research, highlighting challenges in clinical translation and proposing future development prospects.
Review
Oncology
Jinxiang Wu et al.
Summary: Understanding the formation mechanism of tumor immune microenvironment (TIME) is crucial for overcoming cancer. Pyroptosis has a dual role in modulating TIME. While several treatments targeting pyroptosis have been developed, the majority are still in preclinical studies and only a few have been used in clinic with unsatisfactory outcomes. Further research is needed to determine the role of pyroptosis in cancer and realize the application of pyroptosis-targeted treatments in clinical settings.
BIOMARKER RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Yixuan Liu et al.
Summary: This study reports the development of a polymer-based nanodrug delivery system for the efficient treatment of breast cancer using a combination of pyroptosis-starvation-chemotherapy. The system demonstrates targeted delivery to tumor sites, pH responsiveness, synergistic effect, and lack of severe side effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Leihou Shao et al.
Summary: Pyroptosis is a new type of regulated cell death that has great potential for treating cancers. However, current strategies to regulate cancer cell pyroptosis have limitations. In this study, biodegradable metal-organic frameworks (MOFs) were used to deliver glucose oxidase (GOx) intracellularly, promoting intracellular biocatalysis and selectively inducing cancer cell pyroptosis. The strategy of harnessing biodegradable MOFs for protein delivery and intracellular biocatalysis provides a powerful approach to regulate tumor cell pyroptosis for advanced therapeutic development.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Su -Wen Zhu et al.
Summary: In this study, pH-responsive nanomicelles (PDO NPs) were designed by loading a small molecular pro-drug synthesized by the Src inhibitor dasatinib and the chemotherapy drug oxaliplatin into the amphiphilic block copolymer iPDPA to enhance the immunological effects of chemotherapy for HNSCC. These nanomicelles can efficiently accumulate in tumor cells and achieve pH-responsive drug release. The PDO NPs can induce pyroptosis of tumor cells and potentiate antitumor immunity in subcutaneous and syngenetic orthotopic HNSCC mouse models, presenting a promising strategy to enhance immunochemotherapy for HNSCC.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Sijia Zhang et al.
Summary: This study explores the combination of regulating tumor glycometabolism with anti-PD-L1 therapy for tumor treatment. By using nanoparticles combined with anti-PD-L1, tumor development is significantly inhibited, increasing the survival time of mice. This strategy also has an immunological memory effect, successfully preventing tumor recurrence and metastasis.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Jia-Ying Zhou et al.
Summary: The new nanocomposite TiO2@Ru@siRNA has potential therapeutic effects on oral squamous cell carcinoma by reshaping the immune microenvironment through downregulating immunosuppressive factors, upregulating immune factors, and activating immune cells.
Article
Biochemical Research Methods
Minjun Kim et al.
Summary: Metal-organic frameworks (MOFs) are crystalline porous materials formed by coordination bonding between inorganic and organic species, with large specific surface areas and porosities. The direct carbonization of MOFs improves their conductivity, making them suitable for electrochemical applications.
Article
Multidisciplinary Sciences
Zhaoting Li et al.
Summary: Blocking cell membrane repair and sustained release of pro-inflammatory substances can enhance tumor cell pyroptosis and boost the anti-tumor immune response.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Wei Qiu et al.
Summary: This study introduces MRC nanoparticles that utilize the acidic tumor microenvironment to induce pyroptosis and enhance immune efficacy by delivering immune agonists and photosensitizers. The results show that this novel approach can remodel the tumor microenvironment and increase antitumor immunity. The study also provides insights into the molecular mechanisms underlying these therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Yang Gao et al.
Summary: A self-assembled peptide derivative (NSBSO) based on BSO was developed to selectively deplete tumor GSH and inhibit its biosynthesis, leading to ferroptosis and pyroptosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fernando Menegatti de Melo et al.
Summary: Inflammasomes are cytosolic complexes that play a vital role in host defense against pathogens and tissue damage. This study shows that quantum-dot-based iron oxide nanoparticles can activate the NLRP3 inflammasome and release proinflammatory cytokines. The activation is more pronounced when the nanoparticles are taken up by cells before inflammatory stimulation. These findings have implications for using the nanoparticles as both imaging and therapeutic tools.
Article
Chemistry, Multidisciplinary
Meng Wang et al.
Summary: This study utilizes pyroptosis-induced immune responses to promote immunotherapy in pancreatic cancer, transforming the tumor microenvironment and inhibiting tumor growth while attacking distant tumors.
Review
Oncology
Theodora Katopodi et al.
Summary: Chemoresistance in cancer is a significant issue, but cancer nanotherapeutics offer potential solutions through innovative delivery systems. However, challenges such as tumor biology complexity and a lack of complete understanding of nano-bio interactions remain obstacles to clinical translation and commercialization.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rui Sun et al.
Summary: The enhanced permeability and retention (EPR) effect has been considered the basis of tumor-targeted drug delivery, but its heterogeneity and limitations in clinical practice are now being recognized. Researchers are exploring alternative strategies independent of the EPR effect.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Immunology
Xiang Wei et al.
Summary: This article reviews the mechanisms, newly discovered influencing factors, anti-tumoral properties, and applications of pyroptosis in various diseases. Moreover, it provides updates on potential targeted therapies for inflammation and cancers, methods for clinical prevention, and addresses the challenges and future directions in the field.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Saba Daliran et al.
Summary: C-H functionalization, although simple, requires highly active and selective catalysts. Recent research has focused on using porous materials such as MOFs, COFs, and POPs as heterogeneous catalysts, due to their promising activity and tunability. These materials offer structural uniformity, easy tunability, and permanent porosity, and their catalytic selectivity can be controlled through engineering their microenvironments.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jie Tang et al.
Summary: This study demonstrates the synthesis of sodium stabilized mesoporous aluminosilicate nanoparticles as modulators for dendritic cell pyroptosis and antigen carriers, which significantly activate DC and induce pyroptotic cell death. In vivo studies show that these nanoparticles enhance cellular and humoral immune responses.
Review
Chemistry, Multidisciplinary
Xianbin Ma et al.
Summary: Nanogels, as a versatile drug delivery system, play a crucial role in cancer immunotherapy, offering advantages such as enhanced drug bioavailability and reduced immune-related adverse events.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Qingzhu Jia et al.
Summary: With advances in sequencing and instrument technology, bioinformatics analysis is being applied to large batches of single cells. Single-cell sequencing can be used to evaluate the characteristics of tumors, stromal cells, or immune cells and understand tumor progression, response to environmental changes, complexity of the tumor microenvironment, and interactions between cells. Additionally, single-cell analysis is crucial for exploring disease progression, guiding clinical decision-making, and facilitating precision treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Oncology
Naiem T. Issa et al.
Summary: In recent years, there has been exponential growth in knowledge of cancer initiation, progression, and metastasis, although challenges remain in cancer therapeutics. With the high cost of developing new drugs, repurposing existing medications has become an attractive option. Advances in computational modeling and machine learning have facilitated the discovery of new therapeutic targets and drug associations.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jingchao Li et al.
Summary: Immunotherapy harnesses the immune system to eliminate malignant cells, but faces challenges such as limited patient response rates and immune-related adverse events. Electromagnetic nanomaterials can induce immunogenic cell death and are used in combination with cancer immunotherapy for reprogramming the tumor microenvironment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Dan Wu et al.
Summary: Pyroptosis, a unique form of programmed cell death, has been closely associated with human diseases like inflammatory diseases and malignant tumors. Recent progress in cancer treatment based on nanoparticles-induced pyroptosis highlights design features and therapeutic advantages, while also proposing future directions in this emerging area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Sohail et al.
Summary: Nanocarriers have become a focus in cancer research in recent years due to their advantages of good biocompatibility, targeting, and controlled release profiles, potentially overcoming the shortcomings of conventional chemotherapy. Summarizing and analyzing various types of nanocarriers can drive in-depth research and development in this field.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Shiyao Zhou et al.
Summary: The study successfully designed a nanoplatform to trigger apoptosis-pyroptosis transformation and disrupt MDSC-mediated immunosuppression, achieving potent immune responses.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Sang Ah Yi et al.
Summary: Recent advances in 3D cell culture technology have enabled scientists to generate stem cell derived organoids that mimic the structural and functional characteristics of native organs. Current technologies are striving to identify essential factors for controlling organoid development processes, while there is a growing demand for engineering dynamic environments to generate reproducible and reliable organoids. Innovative biomaterial-based and advanced engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate research development.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Yang Lu et al.
Summary: NBS-1MT, an organic photo-immune activator, effectively triggers pyroptosis and disrupts the suppressive tumor microenvironment, activating the immune response and inhibiting tumor growth.
Review
Chemistry, Multidisciplinary
Linlin Duan et al.
Summary: Functional mesoporous materials are synthesized through self-assembly at different interfaces, allowing for unique mesostructures and precise control. Controlling interfacial tension is crucial for influencing the self-assembly process, and recent breakthroughs based on the monomicelles assembly mechanism show promise for enhancing synthesis efficiency and precision of mesoporous materials.
Review
Oncology
Sheera R. Rosenbaum et al.
Summary: Using immune checkpoint inhibitors (ICI) has significantly improved overall survival for certain cancer patients, but many tumors do not respond due to a lack of tumor-infiltrating lymphocytes (TIL). Converting immune cold tumors to hot tumors is a key obstacle in cancer treatment. Promoting tumor-localized necroptosis and pyroptosis may enhance responses to ICI.
Article
Chemistry, Multidisciplinary
Honggang Xiong et al.
Summary: The study highlights the importance of epigenetic alterations and immunosuppressive factors in limiting T cell activation in the tumor microenvironment. The newly designed tumor microenvironment-inspired prodrug nanomicelle releases active substances that inhibit tumor growth by promoting pyroptosis, ultimately enhancing the efficiency of immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Junwei Hou et al.
Summary: ICP and CCP are processes of cell pyroptosis activated by different molecular mechanisms, affecting antitumor immunity and therapeutic outcomes.
Article
Chemistry, Multidisciplinary
Binbin Ding et al.
Summary: This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy, which can release ions to induce intracellular osmotic imbalance and trigger cell death mechanisms. In vivo tests confirm that ZrNPs-induced pyroptosis exhibits superior antitumor immunity activity, inhibiting tumor growth and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Sadia Nadeem et al.
Summary: The study presents a virus-spike tumor-activatable pyroptotic agent for cancer-specific therapy, which can induce pyroptosis in tumor cells. This agent can accumulate in tumors after systemic administration and be degraded by intracellular glutathione to activate inflammasomes and lead to pyroptotic cell death. This structure-dependent and tumor intracellular GSH activatable pyroptotic agent represents a novel paradigm for cancer-specific pyroptotic nanomedicine development.
Article
Chemistry, Multidisciplinary
Xin Liu et al.
Summary: This study introduces an azo-containing polymer for combined photothermal and thermodynamic therapy in the NIR II biowindow, which can induce cancer cell death even under a hypoxic tumor microenvironment. RNA-sequencing is used to reveal the impact of the combined therapy on the cell transcriptome.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Cell Biology
Jia-yuan Zhang et al.
Summary: Pyroptosis is induced by alpha-ketoglutarate through caspase-8-mediated cleavage of GSDMC. This process involves elevation of ROS levels leading to oxidation of DR6 and endocytosis, ultimately resulting in pyroptosis. The acidic environment and production of L-2HG play a crucial role in enhancing the efficiency of alpha-KG-induced pyroptosis in cancer cells.
Article
Chemistry, Multidisciplinary
Yao Xiao et al.
Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.
Review
Engineering, Biomedical
Qian-Ni Ye et al.
Summary: Considerable breakthroughs have been made in the treatment of malignant tumors using antibody drugs, but challenges such as instability in vivo, poor tumor penetration, and limited response rate remain. Biomaterials-based delivery systems have been reported to enhance the efficacy of antibody drugs in recent years. The integration of biomaterials with therapeutic antibodies shows promise in enhancing cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Oncology
Lisha Li et al.
Summary: Pyroptosis is a type of programmed cell death that can activate the immune system to kill cancer cells, yet it may also promote tumor development by changing the immune microenvironment.
Review
Immunology
Yi Huang et al.
Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
Review
Biochemistry & Molecular Biology
Yi Zuo et al.
Summary: Pyroptosis is a programmed cell death mechanism related to Caspase-1, triggering inflammatory reactions by releasing proinflammatory factors. GSDMD plays a key role in pyroptosis, and recent studies have highlighted its importance in the occurrence and development of diabetic nephropathy.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2021)
Review
Medicine, Research & Experimental
Sheng-Kai Hsu et al.
Summary: New types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, have emerged in recent years, playing significant roles in cancer progression modulation and being closely related to immune regulation in the tumor microenvironment. Pyroptosis, in particular, has been identified as crucial for host defense and bridging innate and adaptive immunity, showing benefits for cancer immunotherapies.
Article
Materials Science, Biomaterials
Ying Long et al.
Summary: The newly developed pH-responsive liposome loaded with multiple drugs showed enhanced anti-tumor activity against gastric cancer by inducing apoptosis, autophagy, pyroptosis, and inhibiting tumor invasion and metastasis through the VEGFR2/STAT3 pathway. The naturally-derived hybrid cell membrane coating improved the biointerfacing of nanocomplexes, leading to prolonged circulation time and enhanced targeting ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Physical
Rui Xu et al.
Summary: The study presents a dual-inductive nano-system for anti-cancer effects through ferroptosis and pyroptosis, utilizing a nanodrug constructed with piperlongumine-loaded metal-organic framework coated with transferrin-decorated pH sensitive lipid layer. The nanodrug demonstrated ideal anticancer effects in xenograft mice model, proving the effectiveness and promise of the dual-inductive nanoplatform for cancer treatment.
NANOSCALE HORIZONS
(2021)
Review
Nanoscience & Nanotechnology
Yu Fu et al.
Summary: With the development of nanotechnology, carrier-free nanomedicines have emerged as a promising approach to overcome limitations in traditional drug delivery systems. Particularly in the field of cancer immunotherapy, they have shown significant progress and potential.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pian Yu et al.
Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Pharmacology & Pharmacy
Mingming Song et al.
Summary: The study successfully developed a nanoparticle system based on biomaterials for co-delivery of MET and DOX into melanoma tumors, resulting in the inhibition of melanoma progression.
Review
Oncology
Minoru Suzuki
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Immunology
Yuying Liu et al.
SCIENCE IMMUNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Evelyn Ploetz et al.
ADVANCED MATERIALS
(2020)
Review
Cell Biology
Xing He et al.
Article
Multidisciplinary Sciences
Zhiwei Zhou et al.
Article
Multidisciplinary Sciences
Zhibin Zhang et al.
Article
Chemistry, Multidisciplinary
Fei Gong et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Pengfei Zhao et al.
Article
Cell Biology
Junwei Hou et al.
NATURE CELL BIOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Bin Yang et al.
Article
Chemistry, Multidisciplinary
Yang Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Oncology
Qianqian Duan et al.
Article
Chemistry, Multidisciplinary
Peng Gao et al.
Review
Chemistry, Multidisciplinary
Cristobal Quintana et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Review
Chemistry, Multidisciplinary
D. Rodriguez-San-Miguel et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Review
Chemistry, Multidisciplinary
Han Wang et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Review
Immunology
Petr Broz et al.
NATURE REVIEWS IMMUNOLOGY
(2020)
Article
Engineering, Biomedical
Sjoerd T. T. Schetters et al.
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Review
Immunology
Nina Van Opdenbosch et al.
Article
Immunology
Ping-Hsien Lee et al.
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Review
Immunology
Pontus Orning et al.
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Chemistry, Multidisciplinary
Haile Liu et al.
ADVANCED MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Jin-Xuan Fan et al.
Article
Biochemistry & Molecular Biology
Jian Hu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2019)
Review
Chemistry, Multidisciplinary
Kevin J. McHugh et al.
ADVANCED MATERIALS
(2018)
Article
Oncology
Kyohei Nakamura et al.
Editorial Material
Biotechnology & Applied Microbiology
Conor A. Bradley
NATURE REVIEWS DRUG DISCOVERY
(2018)
Article
Multidisciplinary Sciences
Shuhui Bian et al.
Article
Multidisciplinary Sciences
Yupeng Wang et al.
Review
Oncology
Jinjun Shi et al.
NATURE REVIEWS CANCER
(2017)
Article
Chemistry, Multidisciplinary
Liang Cheng et al.
ADVANCED FUNCTIONAL MATERIALS
(2017)
Article
Chemistry, Multidisciplinary
Ming-Xue Wu et al.
ADVANCED MATERIALS
(2017)
Article
Engineering, Biomedical
Yonghui Lu et al.
Article
Multidisciplinary Sciences
Jingjin Ding et al.
Review
Pharmacology & Pharmacy
Yoshiro Tahara et al.
ADVANCED DRUG DELIVERY REVIEWS
(2015)
Article
Biochemistry & Molecular Biology
Sylvia F. Boj et al.
Article
Cell Biology
Wan-ting He et al.
Review
Chemistry, Multidisciplinary
Maria Molina et al.
CHEMICAL SOCIETY REVIEWS
(2015)
Article
Multidisciplinary Sciences
Jianjin Shi et al.
Article
Biochemistry & Molecular Biology
Hui Gao et al.
Review
Pharmacology & Pharmacy
Nicolas Bertrand et al.
ADVANCED DRUG DELIVERY REVIEWS
(2014)
Review
Pharmacology & Pharmacy
Johan Unga et al.
ADVANCED DRUG DELIVERY REVIEWS
(2014)
Review
Biochemistry & Molecular Biology
H. Inoue et al.
CELL DEATH AND DIFFERENTIATION
(2014)
Article
Multidisciplinary Sciences
Jiujiu Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Review
Oncology
Manuel Hidalgo et al.
Article
Biochemistry & Molecular Biology
Robert F. Murphy
NATURE CHEMICAL BIOLOGY
(2011)
Article
Oncology
Shuiping Tu et al.
Review
Chemistry, Multidisciplinary
Maria Vallet-Regi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2007)
Review
Oncology
RE Peschel et al.
