Relapse primary central nervous system lymphoma successfully consolidated with allogeneic stem cell transplantation with thiotepa/busulfan/fludarabine conditioning

Primary central nervous system lymphoma (PCNSL) is generally characterized by a poor prognosis and frequent relapsing disease. Consolidation therapy in the upfront setting usually consists of an autologous stem cell transplantation. We report the case of a 19-year old Caucasian male who had previously undergone an allogeneic stem cell transplantation with complete engraftment for the treatment of juvenile myelomonocytic leukaemia when he was one year old. He presented with two episodes of (donor-derived) PCNSL from allogeneic stem cells, however after induction chemotherapy he failed to harvest stem cells for the consolidation with autologous stem cell transplantation. He was consolidated successfully with a second allogeneic stem cell transplantation with another donor after conditioning with thiotepa, busulfan and fludarabine.

Automated summary

We report a case of a 19-year-old patient who experienced two episodes of donor-derived PCNSL after undergoing allogeneic stem cell transplantation in childhood. Despite failed induction chemotherapy, successful consolidation therapy was achieved through a second allogeneic stem cell transplantation after conditioning with thiotepa, busulfan, and fludarabine.