4.8 Article

Tetrahedral Framework Nucleic Acids Based Small Interfering RNA Targeting Receptor for Advanced Glycation End Products for Diabetic Complications Treatment

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

A dynamic DNA tetrahedron framework for active targeting

Taoran Tian et al.

Summary: An active targeting strategy-enabled DNA tetrahedron delivery vehicle has been developed for stable drug encapsulation and stimuli-responsive on-demand release, providing a universal platform for various drug delivery requirements.

NATURE PROTOCOLS (2023)

Article Chemistry, Multidisciplinary

Typhaneoside-Tetrahedral Framework Nucleic Acids System: Mitochondrial Recovery and Antioxidation for Acute Kidney Injury treatment

Ran Yan et al.

Summary: Acute kidney injury (AKI) is a global problem with high mortality rate and is also a risk factor for chronic kidney disease. This study developed a promising nanomedicine, tFNA-Typ complex (TTC), which can target mitochondria and renal tubule, and has enhanced antiapoptotic and antioxidative effects, as well as promoting mitochondria and kidney function restoration. This dual-targeted nanoparticle could have critical clinical applications for AKI treatment in the future.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

Effects of Puerarin-Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head

Yuxuan Zhao et al.

Summary: Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease that causes severe pain and poor quality of life. Puerarin (Pue), a natural isoflavone glycoside, shows potential in treating ONFH by promoting osteogenesis and inhibiting apoptosis of bone mesenchymal stem cells (BMSCs). However, the limitations of Pue, such as low solubility, fast degradation, and inadequate bioavailability, hinder its clinical application. In this study, tetrahedral framework nucleic acids (tFNAs) are used as carriers for Pue, resulting in a tFNA/Pue complex (TPC) that exhibits enhanced stability, biocompatibility, and tissue utilization. In vitro and in vivo models are established to investigate the effects of TPC on osteogenesis and apoptosis of BMSCs under glucocorticoid-induced conditions. The findings demonstrate that TPC can restore osteogenesis dysfunction and attenuate BMSC apoptosis through hedgehog and Akt/Bcl-2 pathways, offering a promising treatment for GC-induced ONFH.

SMALL (2023)

Article Chemistry, Multidisciplinary

Functionalized DNA Nanomaterials Targeting Toll-Like Receptor 4 Prevent Bisphosphonate-Related Osteonecrosis of the Jaw via Regulating Mitochondrial Homeostasis in Macrophages

Tao Zhang et al.

Summary: A tetrahedral DNA nanomaterial (TDN-TLR4-4siR) modified with Toll-like receptor 4 (TLR4) siRNA on each vertex successfully reversed the imbalance in polarization of M1 macrophages induced by Zoledronic Acid (ZA) treatment, reducing the proportion of M1 macrophages. TDN-TLR4-4siR also decreased intracellular ROS production and restored mitochondrial membrane potential. Additionally, the TDN-TLR4-4siR group exhibited decreased sequestra formation and accelerated healing of the extraction wound, resulting in a reduced incidence of rat BRONJ by reprogramming polarized macrophages. Therefore, this study establishes a novel strategy using TDN-TLR4-4siR nanomaterial to regulate mitochondrial homeostasis of polarized macrophages to prevent BRONJ.

ADVANCED FUNCTIONAL MATERIALS (2023)

Article Chemistry, Multidisciplinary

Amelioration of Osteoarthritis via Tetrahedral Framework Nucleic Acids Delivering Microrna-124 for Cartilage Regeneration

Sirong Shi et al.

Summary: This study presents a novel therapeutic strategy for osteoarthritis (OA) treatment by synthesizing tetrahedral framework nucleic acids (tFNAs) carrying miR-124 (T-miR3). T-miR3 efficiently prevents OA progression by inhibiting chondrocyte apoptosis, smoothing cartilage surfaces, suppressing extracellular matrix degradation, and increasing synovial thickness.

ADVANCED FUNCTIONAL MATERIALS (2023)

Article Chemistry, Multidisciplinary

A Transdermal Drug Delivery System Based on Nucleic Acid Nanomaterials for Skin Photodamage Treatment

Yu Xie et al.

Summary: A transdermal drug delivery system, composed of tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA), is developed for the topical treatment of skin photodamage. The tFNAs-LA (TLA) nanocomposite exhibits excellent biocompatibility and various therapeutic effects. In both in vitro and in vivo experiments, TLA promotes tissue healing, inhibits apoptosis activation and reactive oxygen species production, and regulates inflammatory responses.

ADVANCED FUNCTIONAL MATERIALS (2023)

Review Chemistry, Multidisciplinary

Functionalizing Framework Nucleic-Acid-Based Nanostructures for Biomedical Application

Tao Zhang et al.

Summary: This article discusses the strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) and their potential biomedical applications. tFNAs have the ability to scavenge reactive oxygen species, enhance cellular endocytosis and tissue permeability, and promote cell-material interactions. They can be used to treat inflammatory and degenerative diseases, and also have potential applications in targeted therapies, tissue regeneration, antitumor strategies, and antibacterial treatment through their structural programmability.

ADVANCED MATERIALS (2022)

Article Biochemistry & Molecular Biology

The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration

Luqin Wan et al.

Summary: This study reveals that inflammation and cell pyroptosis mediated by the NLRP3 inflammasome play a promoting role in the pathogenesis of diabetic keratopathy (DK). Under physiological conditions, the NLRP3 inflammasome is necessary for corneal wound healing and nerve regeneration. However, under the diabetic condition, sustained activation of the NLRP3 inflammasome leads to delayed corneal wound healing and impaired nerve regeneration. Mechanistically, accumulated advanced glycation end products (AGEs) promote hyperactivation of the NLRP3 inflammasome through ROS production. Blocking the AGEs/ROS/NLRP3 inflammasome axis significantly accelerates diabetic corneal epithelial wound closure and nerve regeneration.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Review Genetics & Heredity

Drug delivery systems for RNA therapeutics

Kalina Paunovska et al.

Summary: This article provides an overview of the importance of RNA-based gene therapy and describes the molecular mechanisms of RNA therapies and different drug delivery systems. It also discusses the path from preclinical research to clinical approval for these therapies.

NATURE REVIEWS GENETICS (2022)

Review Biochemistry & Molecular Biology

Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives

Mariyam Khalid et al.

Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.

BIOMOLECULES (2022)

Article Endocrinology & Metabolism

Exercise-Linked Skeletal Irisin Ameliorates Diabetes Associated Osteoporosis by Inhibiting the Oxidative Damage-Dependent miR-150-FNDC5/Pyroptosis Axis

Jyotirmaya Behera et al.

Summary: Recent evidence suggests that physical exercise has a positive impact on skeletal development and can protect against bone loss and deterioration. This study investigated the effects of exercise on bone mass and mechanical quality in mice with type 2 diabetes mellitus. The results showed that diabetes leads to a decrease in Irisin, which further contributes to bone loss through inflammation. Exercise, along with certain interventions, can restore Irisin levels and improve bone formation in diabetic mice. This study demonstrates that exercise-induced skeletal Irisin can ameliorate diabetes-associated glucose intolerance and bone loss.

DIABETES (2022)

Article Chemistry, Multidisciplinary

Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral-Framework Nucleic-Acid Nanostructures Functionalized with Osteogenic Growth Peptide

Tianxu Zhang et al.

Summary: OGP-tFNAs can protect hematopoietic cells and their microenvironment from chemotherapy-induced injuries and myelosuppression, while promoting hematopoiesis regeneration.

ADVANCED SCIENCE (2022)

Article Chemistry, Multidisciplinary

A Lysosome‐Activated Tetrahedral Nanobox for Encapsulated siRNA Delivery (Adv. Mater. 46/2022)

Yang Gao et al.

ADVANCED MATERIALS (2022)

Review Cell & Tissue Engineering

Prospects and challenges of dynamic DNA nanostructures in biomedical applications

Taoran Tian et al.

Summary: DNA nanostructures, with their predictable physicochemical nature, have been widely utilized in various fields, particularly in biomedical applications. These structures possess stimulus-responsive mechanisms that enable their application in basic research, drug delivery, biosensor development, and tissue engineering. However, there are challenges to overcome regarding their clinical translation.

BONE RESEARCH (2022)

Review Food Science & Technology

The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

Domenico Sergi et al.

Summary: AGEs are a group of molecules produced through non-enzymatic reactions, implicated in complications of diabetes and metabolic health, contributing to the development of type 2 diabetes and obesity.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Article Medicine, Research & Experimental

Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats

Nada H. Eisa et al.

Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Multidisciplinary Sciences

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Zhengzheng Yan et al.

Summary: SLP76 plays an important role in RAGE-mediated pro-inflammatory signaling, and targeting its signaling pathway could be a therapeutic approach for sepsis.

NATURE COMMUNICATIONS (2021)

Article Urology & Nephrology

Targeting inflammation through RAGE antagonism

Monica Wang

Nature Reviews Nephrology (2021)

Article Cell Biology

Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice

Michaele B. Manigrasso et al.

Summary: RAGE antagonists have beneficial effects on diabetes complications, but usually target the extracellular domains of RAGE. However, a small molecule antagonist targeting the ctRAGE-DIAPH1 interaction, known as RAGE229, has shown positive effects in mitigating diabetic complications by attenuating inflammatory signaling.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

AGE/RAGE in diabetic kidney disease and ageing kidney

Xia-Qing Wu et al.

Summary: Diabetic kidney disease is a major cause of chronic kidney disease, and controlling blood glucose is effective in preventing it. However, the formation of AGEs related to high glucose plays a central role in the pathogenesis of DKD, causing oxidative stress and inflammation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Chemistry, Medicinal

Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

Selena Le Bagge et al.

MEDICINAL RESEARCH REVIEWS (2020)

Review Urology & Nephrology

Genetics of diabetes mellitus and diabetes complications

Joanne B. Cole et al.

NATURE REVIEWS NEPHROLOGY (2020)

Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Biochemistry & Molecular Biology

Therapeutic siRNA: state of the art

Bo Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Chemistry, Multidisciplinary

DNA Nanotechnology-Enabled Drug Delivery Systems

Qinqin Hu et al.

CHEMICAL REVIEWS (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Review Genetics & Heredity

RNases H: Structure and mechanism

Malwina Hyjek et al.

DNA REPAIR (2019)

Article Dentistry, Oral Surgery & Medicine

The effect of NLRP inflammasome on the regulation of AGEs-induced inflammatory response in human periodontal ligament cells

Xiaowei Yi et al.

JOURNAL OF PERIODONTAL RESEARCH (2019)

Review Endocrinology & Metabolism

Clinical/Translational Aspects of Advanced Glycation End-Products

Chang Zeng et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Review Food Science & Technology

Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents

Mohammad Alizadeh et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Review Endocrinology & Metabolism

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Yan Zheng et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Review Medicine, Research & Experimental

Targeting RAGE Signaling in Inflammatory Disease

Barry I. Hudson et al.

ANNUAL REVIEW OF MEDICINE, VOL 69 (2018)

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Review Nutrition & Dietetics

Dietary Advanced Glycation End Products and Their Role in Health and Disease

Jaime Uribarri et al.

ADVANCES IN NUTRITION (2015)

Review Biochemistry & Molecular Biology

Role of advanced glycation end products in cellular signaling

Christiane Ott et al.

REDOX BIOLOGY (2014)

Review Chemistry, Physical

Delivery materials for siRNA therapeutics

Rosemary Kanasty et al.

NATURE MATERIALS (2013)

Review Endocrinology & Metabolism

AGE restriction in diabetes mellitus: a paradigm shift

Helen Vlassara et al.

NATURE REVIEWS ENDOCRINOLOGY (2011)

Review Cardiac & Cardiovascular Systems

Advanced glycation end products - Sparking the development of diabetic vascular injury

Alison Goldin et al.

CIRCULATION (2006)

Article Biochemistry & Molecular Biology

Asymmetry in the assembly of the RNAi enzyme complex

DS Schwarz et al.