4.8 Article

Phenylboronic Acid-Modified Gold Nanoclusters as a Nanoantibiotic to Treat Vancomycin-Resistant Enterococcus faecalis-Caused Infections

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Multi-Targeted Peptide-Modified Gold Nanoclusters for Treating Solid Tumors in the Liver

Feng Xiao et al.

Summary: In this study, a modified nanoparticle aggregate (AP(1)P(2)-PEG NCs) was designed for the treatment of unresectable solid liver tumors. The findings suggest that the nanoparticle aggregate can achieve the mutual promotion of autophagy and apoptosis in liver tumor cells, leading to a better anti-tumor effect.

ADVANCED MATERIALS (2023)

Article Chemistry, Multidisciplinary

Radiofrequency-Activated Pyroptosis of Bi-Valent Gold Nanocluster for Cancer Immunotherapy

Qingqing Zhang et al.

Summary: Pyroptosis of tumor cells was induced by biGC@PNA with a precisely stoichiometric ratio of Au(I) ion/Au(0) atom through its radiofrequency (RF)-heating effect. The activated pyroptosis resulted in a robust immunogenic cell death (ICD) effect, enhancing the antitumor immune responses and suppressing tumor metastasis and relapse. The noninvasive RF field provides a promising strategy for improving cancer immunotherapy.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain

Xiaoyan Liu et al.

Summary: This study demonstrates that nanoplastics can be deposited in the brain via nasal inhalation, leading to neurotoxicity and altered animal behavior. Smaller nanoplastics particles are more readily taken up by cells and can reach the mouse brain through aerosol inhalation.

NANO LETTERS (2022)

Review Chemistry, Physical

Impact of nanomaterials on the intestinal mucosal barrier and its application in treating intestinal diseases

Wenshuai Hao et al.

Summary: This review comprehensively discusses the impact of typical nanomaterials on the intestinal mucosal barrier (IMB) and summarizes the treatment of intestinal diseases by using nanomaterials. Factors such as dosage, size, morphology, and surface functional groups of nanomaterials influence the effects on the IMB. There is huge potential for nanomaterials to regulate the IMB and achieve optimal therapeutic effects for antibiotics, oral vaccines, and drug carriers.

NANOSCALE HORIZONS (2022)

Article Chemistry, Multidisciplinary

Aminophenol-Decorated Gold Nanoparticles for Curing Bacterial Infections

Le Wang et al.

Summary: This study presents the modification of gold nanoparticles with aminophenol, which demonstrates a broad spectrum of antibacterial effects and strong efficacy against multidrug-resistant bacteria. The mechanisms of action include damaging bacterial cell walls and inhibiting bacterial protein synthesis. In vivo experiments also show promising results in treating abdominal bacterial infections.

NANO LETTERS (2022)

Article Chemistry, Multidisciplinary

Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria

Xiaohui Zhao et al.

Summary: Antibiotic resistance is a serious threat to human health and nanotechnology, particularly gold nanomaterials, provides an effective solution with their excellent antibacterial efficacy and biosafety, making them potential alternatives to traditional antibiotics.

ACS NANO (2022)

Article Multidisciplinary Sciences

ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus-infected chronic skin wound healing

Wenshuai Liu et al.

Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.

SCIENCE ADVANCES (2022)

Article Chemistry, Multidisciplinary

Multifunctional Gold Nanoclusters for Effective Targeting, Near-Infrared Fluorescence Imaging, Diagnosis, and Treatment of Cancer Lymphatic Metastasis

Zeyang Pang et al.

Summary: Developing effective lymph-node targeting and imaging probes is crucial for the early detection and diagnosis of tumor metastasis. Researchers have developed dualligand-/multiligand-capped gold nanoclusters (GNCs) that can specifically target LN cancer metastasis and provide near-infrared fluorescence imaging, diagnosis, and treatment.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Origins of the pH-Responsive Photoluminescence of Peptide-Functionalized Au Nanoclusters

Laura Zanetti-Polzi et al.

Summary: Through theoretical investigation, we have revealed the impact of peptide-ligand environment on the pH-responsive fluorescence of gold nanoclusters. Our findings show that subtle changes in the hexapeptide sequence can significantly alter the pH response of the clusters, providing insights into the underlying mechanism.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Dual-Stage Irradiation of Size-Switchable Albumin Nanocluster for Cascaded Tumor Enhanced Penetration and Photothermal Therapy

Peiying He et al.

Summary: The microenvironment of triple-negative breast cancer (TNBC) reduces the delivery and penetration of therapeutic agents, making it difficult to eliminate cancer cells completely. In this study, a photothermal nanocluster was constructed using a size-shrinkage and ligand modification strategy, allowing for deep penetration and efficient eradication of TNBC cells.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

N-Terminal Lysozyme Conjugation to a Cationic Polymer Enhances Antimicrobial Activity and Overcomes Antimicrobial Resistance

Tong Zhang et al.

Summary: Microbial resistance to antibiotics is a major challenge in global healthcare. A study found that a photoinduced cationic polymer conjugated with lysozyme can effectively overcome bacterial resistance and improve therapeutic efficacy in a rat periodontitis model. This discovery provides an efficient strategy to enhance antimicrobial activities and overcome antimicrobial resistance.

NANO LETTERS (2022)

Article Chemistry, Multidisciplinary

Fluorescent and Antibacterial Aminobenzeneboronic Acid (ABA)-Modified Gold Nanoclusters for Self-Monitoring Residual Dosage and Smart Wound Care

Le Wang et al.

Summary: The smart dressing can self-monitor the amount of residual nanomedicine in order to evaluate the appropriate time points for the replacement of wound dressings, thus preventing secondary damage to wounds. This novel dressing holds great promise for broad clinical applications.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections

Le Wang et al.

Summary: Oral administration of two starting materials can robustly synthesize gold nanoparticles in vivo, which exhibit excellent antibacterial efficacy against multidrug resistant bacteria, long half-life, and high biosafety.

NANO LETTERS (2021)

Review Clinical Neurology

Ototoxicity of Non-aminoglycoside Antibiotics

Leonard P. Rybak et al.

Summary: This review summarizes the ototoxicity of non-aminoglycoside antibiotics, discussing antibiotics such as capreomycin, macrolides, and vancomycin that have been associated with hearing loss in animal studies and in patients, especially in neonates. It emphasizes the importance of being aware of the ototoxic potential of these antibiotics, given the extensive focus on the ototoxicity of aminoglycoside antibiotics in the literature.

FRONTIERS IN NEUROLOGY (2021)

Article Nanoscience & Nanotechnology

Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections

Yangzhouyun Xie et al.

Summary: The long-term and extensive use of antibiotics has led to the emergence of multidrug-resistant bacteria, which is a global public health issue. In this study, non-antibiotic small molecule-modified gold nanoclusters were developed as a potential substitute for commercial antibiotics. The modification of 4,6-diamino-2-pyrimidinethiol (DAPT)-modified AuNCs (DAPT-AuNCs) showed promising results in fighting against a broad spectrum of bacterial strains, including multidrug-resistant ones, and could be applied in innovative dressings for wound care.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Nanoscience & Nanotechnology

Au Nanoclusters Ameliorate Shigella Infectious Colitis by Inducing Oxidative Stress

Xiaoxiao Wu et al.

Summary: This study demonstrates that ultrasmall gold nanoclusters (Au NCs) have bactericidal effects against Shigella and can effectively treat infections. Au NCs interfere with oxidative metabolism genes, increase ROS levels, and disrupt bacterial cell membranes as part of their mechanism of action. In vivo experiments show that Au NCs effectively alleviate intestinal damage caused by Shigella infections.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Chemistry, Multidisciplinary

Controlling the pyridinium-zwitterionic ligand ratio on atomically precise gold nanoclusters allowing for eradicating Gram-positive drug-resistant bacteria and retaining biocompatibility

Zeyang Pang et al.

Summary: In this study, a dual-ligand-functionalised gold nanocluster was developed to combat infections caused by multidrug-resistant bacteria. The gold nanocluster showed effective antibacterial activity against MDR Gram-positive bacteria by inducing bacterial aggregation, disrupting bacterial membrane integrity and potential, and generating reactive oxygen species. Furthermore, combining the gold nanocluster with common antibiotics significantly enhanced its antibacterial activity in both in vitro and animal models of skin infections. This study demonstrates a new strategy using multifunctional gold nanomaterials to address the challenge of MDR bacteria.

CHEMICAL SCIENCE (2021)

Article Nanoscience & Nanotechnology

Gold Nanoclusters as an Antibacterial Alternative Against Clostridium difficile

Huan Yang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Engineering, Biomedical

Synergistic Antimicrobial Titanium Carbide (MXene) Conjugated with Gold Nanoclusters

Kaiyuan Zheng et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Review Chemistry, Multidisciplinary

Surface chemistry of gold nanoparticles for health-related applications

Jiangjiang Zhang et al.

CHEMICAL SCIENCE (2020)

Article Chemistry, Physical

Conjugating gold nanoclusters and antimicrobial peptides: From aggregation-induced emission to antibacterial synergy

Youkun Zheng et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

Article Chemistry, Multidisciplinary

Gold Nanoparticles Cure Bacterial Infection with Benefit to Intestinal Microflora

Juanjuan Li et al.

ACS NANO (2019)

Review Chemistry, Multidisciplinary

Toward Total Synthesis of Thiolate-Protected Metal Nanoclusters

Qiaofeng Yao et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

Review Chemistry, Multidisciplinary

Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity

Zhen Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

Review Infectious Diseases

Vancomycin toxicity in neonates: a review of the evidence

Jodi M. Lestner et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2016)

Review Chemistry, Multidisciplinary

Metal nanoclusters: novel probes for diagnostic and therapeutic applications

Yu Tao et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Biochemistry & Molecular Biology

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria

Ines M. Torcato et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Article Neurosciences

A differentially amplified motion in the ear for near-threshold sound detection

Fangyi Chen et al.

NATURE NEUROSCIENCE (2011)

Letter Microbiology

Is Vancomycin Ototoxicity a Significant Risk?

Ryan K. Shields et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

Article Chemistry, Multidisciplinary

Method for analysis of nanoparticle hemolytic properties in vitro

Marina A. Dobrovoiskaia et al.

NANO LETTERS (2008)

News Item Multidisciplinary Sciences

The bacteria fight back

Gary Taubes

SCIENCE (2008)

Article Immunology

Appropriate antibiotic use and why it is important: the challenges of bacterial resistance

JM Lieberman

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2003)

Review Biotechnology & Applied Microbiology

The future challenges facing the development of new antimicrobial drugs

A Coates et al.

NATURE REVIEWS DRUG DISCOVERY (2002)