4.8 Article

An Extracellular Vesicle-Cloaked Multifaceted Biocatalyst for Ultrasound-Augmented Tendon Matrix Reconstruction and Immune Microenvironment Regulation

Related references

Note: Only part of the references are listed.
Review Orthopedics

Outcomes and Complications of Open Versus Minimally Invasive Repair of Acute Achilles Tendon Ruptures: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Ahmed Khalil Attia et al.

Summary: This study compared the effectiveness of open repair and minimally invasive surgery (MIS) for Achilles tendon ruptures through a comprehensive search and meta-analysis of literature. The results showed that open repair had longer surgical time, higher risk of superificial infections and ankle stiffness, while MIS had a higher risk of temporary sural nerve palsy. The rerupture rate and functional outcomes were similar between the two methods. Therefore, MIS is a safe and reliable technique, but more high-quality research is needed before recommending it as the gold standard for managing Achilles tendon ruptures.

AMERICAN JOURNAL OF SPORTS MEDICINE (2023)

Article Chemistry, Multidisciplinary

Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing

Yuting Deng et al.

Summary: This study develops a cobalt selenide-based biocatalyst with an amorphous Ru@CoSe nanolayer for ultrafast and broadspectrum catalytic ROS-elimination. The biocatalyst shows excellent catalase-like kinetics and can efficiently rescue the proliferation of mesenchymal stem cells in an oxidative stress environment. The study offers an effective nanomedicine for catalytic ROS-scavenging and ultrafast healing of inflammatory wounds, and provides a strategy to design biocatalytic metal compounds.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

A Library of ROS-Catalytic Metalloenzyme Mimics with Atomic Metal Centers

Sujiao Cao et al.

Summary: Metal-N-coordinated centers supported by carbonaceous substrates have been synthesized and compared in terms of catalytic activities, substrate selectivities, kinetics, and reactive oxygen species (ROS) products. The electronic structures of the metal centers were found to be highly related to the ROS-catalytic paths and activities.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Modulating Electron Transfer in Vanadium-Based Artificial Enzymes for Enhanced ROS-Catalysis and Disinfection

Ling Li et al.

Summary: This study reports a new method for designing the active centers of vanadium-based artificial enzymes by modulating electron transfer, which enhances catalytic performance and shows potential for combating drug-resistant bacteria and treating wounds.

ADVANCED MATERIALS (2022)

Article Cell Biology

Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo

Xiangze Li et al.

Summary: The use of EUG-BMSC-EVs can protect TSCs from oxidative stress and enhance their functionality in tendon injury. These findings provide a foundation for the potential clinical use of EUG-BMSC-EVs as a new therapeutic approach for tendon regeneration.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Article Engineering, Biomedical

Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity

Benjamin R. Freedman et al.

Summary: A hydrogel with high-capacity drug storage function has been found to promote tissue healing in tendon injuries. This hydrogel has a tough structure on one side and an adhesive surface on the other, allowing it to support tendon gliding and strong adhesion. Through experiments, it has been shown that this hydrogel enhances healing and reduces scar formation in rat models of tendon rupture, and can sustainably release drugs. It has potential for biomedical applications.

NATURE BIOMEDICAL ENGINEERING (2022)

Article Engineering, Biomedical

Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration

Yue Kang et al.

Summary: In this study, we designed and synthesized an exosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, which enhanced osteogenic, angiogenic and anti-inflammatory capabilities simultaneously. The composite scaffold promoted in vitro osteogenesis and angiogenesis, as well as in vivo new bone formation and osseointegration.

BIOACTIVE MATERIALS (2022)

Article Biochemistry & Molecular Biology

Roles of Oxidative Stress in Acute Tendon Injury and Degenerative Tendinopathy-A Target for Intervention

Pauline Po Yee Lui et al.

Summary: Both acute and chronic tendon injuries are difficult to treat currently. This review explores the potential relationship between oxidative stress and tendon disorders. Inhibiting oxidative stress has been shown to promote tenogenic differentiation and enhance tendon repair. Anti-oxidative therapies have been researched to reduce tendon fibrosis and adhesion, and promote healing in tendinopathy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Multidisciplinary Sciences

Construction of a two-dimensional artificial antioxidase for nanocatalytic rheumatoid arthritis treatment

Bowen Yang et al.

Summary: The study constructs a two-dimensional metal-organic framework nanosheet catalyst that mimics the coordination environments of natural enzymes, and demonstrates its anti-inflammatory and anti-arthritic effects.

NATURE COMMUNICATIONS (2022)

Review Pharmacology & Pharmacy

Effects of BMSC-Derived EVs on Bone Metabolism

Xuchang Zhou et al.

Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.

PHARMACEUTICS (2022)

Article Chemistry, Multidisciplinary

Multifaceted Catalytic ROS-Scavenging via Electronic Modulated Metal Oxides for Regulating Stem Cell Fate

Qinyu Tian et al.

Summary: Developing an electronic modulated metal oxide, Mn-Co3O4, with efficient and multifaceted catalytic ROS-scavenging properties for protecting and regulating stem cells in oxidative-stress microenvironments. It enhances MSCs functions and promotes tissue regeneration, providing a new avenue for designing biocatalytic metal oxides.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Catalase-Mimetic Artificial Biocatalysts with Ru Catalytic Centers for ROS Elimination and Stem-Cell Protection

Yimin Sun et al.

Summary: It is important to explore high-efficiency ROS-elimination materials for combating oxidative stress in various diseases, especially in stem-cell-based biotherapeutics. This study reports an innovative concept of designing ROS-elimination artificial biocatalysts with Ru catalytic centers, which mimic the Fe-N active centers of natural catalase. The results show that the artificial biocatalysts with Ru cluster centers have exceptional ROS-elimination activity and can provide efficient protection for stem cells in high ROS level conditions.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Energy-Supporting Enzyme-Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy

Shikun Wang et al.

Summary: Tendon injury is a prevalent and challenging motor system disease. This study focuses on the insufficient regenerative capability and dysregulation of immune microenvironment as the main causes of functional loss. By designing a smart scaffold, the study successfully repairs the oxidative stress and mitochondrial impairment, remodels the microenvironment, and promotes tendon regeneration.

ADVANCED SCIENCE (2022)

Article Nanoscience & Nanotechnology

Ir Cluster-Anchored MOFs as Peroxidase-Mimetic Nanoreactors for Diagnosing Hydrogen Peroxide-Related Biomarkers

Shengdong Mu et al.

Summary: In this study, a new nanoreactor was created by mimicking peroxidase to meet the needs of bio-diagnosis. The nanoreactor showed exceptional diagnostic activity and high substrate selectivity, enabling ultrasensitive and visual detection of various biomarkers.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Nanoscience & Nanotechnology

Nanoscale Zeolitic Imidazolate Framework-8 Activator of Canonical MAPK Signaling for Bone Repair

Xiaomeng Gao et al.

Summary: This study demonstrates that nano ZIF-8 can drive rat bone mesenchymal stem cells differentiation into osteoblasts, with better osteogenic effect compared to ionic conditions of Zn at the same concentration. The cellular uptake mechanisms were revealed to involve caveolae-mediated endocytosis and macropinocytosis. Additionally, transcriptome sequencing identified upregulation of multiple osteogenic pathways, primarily phosphorylating ERK to activate the canonical mitogen-activated protein kinase pathway for promoting osteogenesis.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA

Meng Zhao et al.

Summary: The study demonstrates that MSC-EVs can alleviate mtDNA damage and inflammation after acute kidney injury, with their effects partially dependent on the TFAM signaling pathway. This suggests that MSC-EVs are promising nanotherapeutics for diseases characterized by mitochondrial damage, highlighting the essential role of TFAM in maintaining their regenerative capacity.

ACS NANO (2021)

Article Biochemical Research Methods

Isolation and characterization of extracellular vesicle subpopulations from tissues

Rossella Crescitelli et al.

Summary: This study presents a protocol for isolating multiple EV subpopulations directly from tissues, including enzymatic treatment, ultracentrifugation, density separation, electron microscopy characterization, etc., which can be completed in 22 hours. The approach can be applied to tissues such as human melanoma metastases and can be adopted by researchers experienced with cell culture and EV isolation.

NATURE PROTOCOLS (2021)

Review Pharmacology & Pharmacy

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

Qian Hu et al.

Summary: Recent studies have shown the importance of extracellular vesicles (EVs) in mediating interactions between macrophages and tissue cells, influencing tissue inflammation, injury, and repair processes. The release of EVs can affect the activation and polarization of macrophages, leading to various inflammatory disease conditions.

ACTA PHARMACEUTICA SINICA B (2021)

Review Pharmacology & Pharmacy

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J. Deprez et al.

Summary: Ultrasound, in addition to its clinical imaging application, has been extensively explored as a tool to enhance drug delivery. Therapeutic ultrasound can permeabilize biological barriers, enabling drugs to reach otherwise impermeable tissues and offering a new approach for drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Multidisciplinary Sciences

Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria

Yanping Long et al.

Summary: The rise of drug-resistant bacteria poses a threat to human health, requiring the development of new non-antibiotic strategies. In this study, researchers have synthesized a hedgehog artificial macrophage capable of effectively combating MRSA, potentially paving the way for the development of novel antibacterial materials.

NATURE COMMUNICATIONS (2021)

Review Orthopedics

Treatment of Acute Achilles Tendon Ruptures: A Systematic Review and Meta-analysis of Complication Rates With Best- and Worst-Case Analyses for Rerupture Rates

Dexter Seow et al.

Summary: The meta-analysis showed that surgical treatment was superior to nonsurgical treatment in terms of reruptures, while minimally invasive surgery was found to be advantageous over open repair, particularly for minor complications. No single treatment option was significantly favorable across all complications, highlighting the need for individualized decisions based on the specific case.

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

Article Orthopedics

Dynamic exacerbation in inflammation and oxidative stress during the formation of peritendinous adhesion resulted from acute tendon injury

Pengfei Li et al.

Summary: The study found that various indicators, such as inflammatory factors and oxidative stress, significantly increased 24 hours after tendon injury, while fibrosis and inflammation around the tendon began to worsen 48 hours after surgery. Prompt and effective measures should be taken as soon as possible after tendon injury.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

Article Nanoscience & Nanotechnology

Homology and Immune Checkpoint Dual-Targeted Sonocatalytic Nanoagents for Enhancing Sonodynamic Tumor Therapy

Xin Wei et al.

Summary: A new TiO2-based Sonocatalytic nanoagent functionalized with malignant melanoma cell membrane and programmed cell death-ligand 1 antibody was synthesized for enhanced sonodynamic tumor therapy. In vitro experiments proved that the functionalized nanoagent exhibited precise targeting effects and high tumor cell uptake, resulting in the generation of localized ROS for tumor cell killing.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Nanoscience & Nanotechnology

Conjugated Coordination Porphyrin-based Nanozymes for Photo-/Sono-Augmented Biocatalytic and Homologous Tumor Treatments

Fangxue Du et al.

Summary: A novel malignant melanoma cell membrane-coated Pd-based CP nanoplatform (Trojan Porzymes) has been synthesized for biocatalytic and homologous tumor therapies, showing high CP loading ratio, uniform nanoscale size, single-atom nanostructure, homologous targeted ability, and high-efficiency photo/sono-augmented biocatalytic activities. The Trojan Porzymes can generate abundant center dot OH and O-1(2) via chemodynamic path and visible light or ultrasound excitation, and they demonstrate homologous targeting ability to tumor cells and efficient accumulation in cancer tissues. This research may provide a new strategy for future clinical malignant melanoma treatments by combining biocatalytic and homologous approaches.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Pd-Single-Atom Coordinated Biocatalysts for Chem-/Sono-/Photo-Trimodal Tumor Therapies

Fangxue Du et al.

Summary: A novel and facile Pd-single-atom-coordinated porphyrin-based polymeric network for chem-/sono-/photo-trimodal tumor therapies has been designed, showing highly efficient biocatalytic sites and synergistic trimodal therapeutic effects in both in vitro and in vivo experiments.

ADVANCED MATERIALS (2021)

Article Multidisciplinary Sciences

Gradient bimetallic ion-based hydrogels for tissue microstructure reconstruction of tendon-to-bone insertion

Renhao Yang et al.

Summary: The gradient bimetallic ion-based hydrogel, constructed through one-step coordinative crosslinking of sulfhydryl groups with copper and zinc ions, can induce regenerative capacity in vitro while simultaneously promoting tenogenesis and osteogenesis, showing significant effects on tissue regeneration in a rat rotator cuff tear model.

SCIENCE ADVANCES (2021)

Review Nanoscience & Nanotechnology

Extracellular vesicle-coated nanoparticles

Parinaz Fathi et al.

Summary: Synthetic nanoparticles have been used for theranostic applications in targeting imaging and therapy of diseased tissues. Coating nanoparticles with membrane-derived extracellular vesicles (EVs) offers a promising approach for expanding nanoparticle targeting and enhancing immune evasion properties for increased circulation time. Applications of EV coating on nanoparticles are mainly focused on cancer treatment.
Article Emergency Medicine

Effects of extracellular vesicles from mesenchymal stem cells on oxygen-glucose deprivation/reperfusion-induced neuronal injury

Shuang-shuang Gu et al.

Summary: This study demonstrated the neuroprotective effects of BMSC-sEVs against OGD/R-induced cell injury by suppressing oxidative stress and apoptosis processes. The Ca2+/CaMK II signaling pathways may be involved in this neuroprotection mechanism.

WORLD JOURNAL OF EMERGENCY MEDICINE (2021)

Article Cell & Tissue Engineering

Exosome-educated macrophages and exosomes differentially improve ligament healing

Connie S. Chamberlain et al.

Summary: The researchers used exosomes from MSCs to improve healing effects and compared the therapeutic effects of exosomes and EEMs in different models. The results showed that both exosomes and EEMs can improve healing outcomes through different mechanisms, facilitating tissue remodeling.

STEM CELLS (2021)

Review Orthopedics

The role of the macrophage in tendinopathy and tendon healing

Joo Y. Sunwoo et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

Article Chemistry, Multidisciplinary

Metal-Organic-Framework-Engineered Enzyme-Mimetic Catalysts

Lang Ma et al.

ADVANCED MATERIALS (2020)

Article Orthopedics

Postoperative Complications Following Repair of Acute Achilles Tendon Rupture

X. J. Ruben Stavenuiter et al.

FOOT & ANKLE INTERNATIONAL (2019)

Article Cell & Tissue Engineering

Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing

Connie S. Chamberlain et al.

STEM CELLS (2019)

Article Medicine, Research & Experimental

Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells regulate inflammation and enhance tendon healing

Zhengzhou Shi et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Review Cell Biology

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

Ankita Nandi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Multidisciplinary Sciences

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Tuying Yong et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

Peng Qin et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Oncology

A revisited concept: Contact inhibition of growth. From cell biology to malignancy

Domenico Ribatti

EXPERIMENTAL CELL RESEARCH (2017)

Review Rheumatology

Inflammatory mechanisms in tendinopathy - towards translation

Neal L. Millar et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Article Chemistry, Physical

Exosome-Coated Metal-Organic Framework Nanoparticles: An Efficient Drug Delivery Platform

Bernhard Illes et al.

CHEMISTRY OF MATERIALS (2017)

Review Nutrition & Dietetics

Nutritional research may be useful in treating tendon injuries

Luke Curtis

NUTRITION (2016)

Article Multidisciplinary Sciences

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease

Neal L. Millar et al.

NATURE COMMUNICATIONS (2015)

Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

Laura Ann Mulcahy et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Article Biochemistry & Molecular Biology

Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs

Hongjiang Ruan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Orthopedics

Light microscopic histology of Achilles tendon ruptures - A comparison with unruptured tendons

N Maffulli et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2000)