3D Printed Customizable Microsampling Devices for Neuroscience Applications

Multifunctional devices that incorporate chemical or physical measurements combined with ways to manipulate brain tissue via drug delivery, electrical stimulation, or light for optogenetics are desired by neuroscientists. The next generation in vivo brain devices will likely utilize the extensive flexibility and rapid processing of 3D printing. This Perspective demonstrates how close we are to this reality for advanced neuroscience measurements. 3D printing provides the opportunity to improve microsampling-based devices in ways that have not been previously available. Not only can 3D printing be used for actual device creation, but it can also allow printing of peripheral objects necessary to assemble functional devices. The most probable 3D printing set up for microsampling devices with appropriate nm to mu m feature size will likely require 2-photon polymerization-based printers. This Perspective describes the advantages and challenges for 3D printing of microsampling devices as an initial step to meet the next generation device needs of neuroscientists.

Automated summary

This Perspective article discusses the potential of 3D printing technology in improving neuroscience measurement devices. It explores the use of 3D printing for device creation and the printing of peripheral objects required for functional devices. The most suitable 3D printing setup for microsampling devices with specific feature sizes is likely to involve 2-photon polymerization-based printers.