Chemodynamic/Photothermal Synergistic Cancer Immunotherapy Based on Yeast Microcapsule-Derived Au/Pt Nanoparticles

In recent years, microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, the use of microorganisms alone to activate the immune response for antitumor therapy was unsatisfactory. In this study, we biosynthesized gold nanoparticles (AuNPs) and platinum nanoparticles (PtNPs) based on yeast microcapsules to activate the immune response for antitumor treatment in synergy with chemodynamic therapy (CDT) and photothermal therapy (PTT). We generated AuNPs and PtNPs on yeast microcapsules (YAP) and fabricated nanoscale particles (Bre-YAP) by ultrasonic fragmentation and differential centrifugation. Bre-YAP retained the glucan component of yeast as an adjuvant; in the meantime, these two kinds of metal nanoparticles contained were excellent CDT and PTT mediators. By inspection, they could reach a high level of distribution in tumors and tumor-draining lymph nodes (TDLNs). Under the laser irradiation of tumors, this immunological nanomaterial significantly remodeled the microenvironments of tumors and TDLNs. The primary tumors were effectively inhibited or even eradicated, and the overall survival of mice was significantly improved as well. Therefore, yeast microcapsule-based Bre-YAP with immune properties could be used as an effective cancer treatment modality.

Automated summary

Microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, using microorganisms alone for antitumor therapy was unsatisfactory. In this study, gold nanoparticles and platinum nanoparticles were synthesized based on yeast microcapsules to activate the immune response for antitumor treatment in synergy with chemodynamic therapy and photothermal therapy. The results showed that this immunological nanomaterial significantly improved the tumor microenvironments, effectively inhibiting or even eradicating primary tumors and improving the overall survival of mice. Therefore, yeast microcapsule-based immunomodulatory nanoparticles could be an effective cancer treatment modality.