4.8 Article

Combinatorial Screening of Cationic Lipidoids Reveals How Molecular Conformation Affects Membrane-Targeting Antimicrobial Activity

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Multiple Routes to Bicontinuous Cubic Liquid Crystal Phases Discovered by High-Throughput Self-Assembly Screening of Multi-Tail Lipidoids

James Jennings et al.

Summary: In this article, a high-throughput synthesis of lipidoids that assemble into liquid crystalline phases is conducted. The screening approach leads to the discovery of 12 different lipidoid structures capable of forming bicontinuous double gyroid phases. Unexpected design criteria for phase selection are uncovered through small-angle X-ray scattering (SAXS) data. Two examples of functional materials from lipidoid liquid crystals are demonstrated.

SMALL (2023)

Review Chemistry, Medicinal

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

Evgeniya A. Saverina et al.

Summary: In the past, the focus was mainly on individual antibacterial activity, but now there is a shift towards affecting more complex cellular frameworks and using multiple strategies to combat biofilms at different stages. Quaternary ammonium compounds (QACs) play a key role in these treatments. This review summarizes the literature data on the effectiveness of using commercially available and newly synthesized QACs, as well as synergistic treatment techniques based on them. It also discusses the development and application of antimicrobial coatings to prevent biofilm formation on various surfaces.

ACS INFECTIOUS DISEASES (2023)

Article Infectious Diseases

Structure-Activity Relationships of Cationic Lipidoids against Escherichia coli

James Jennings et al.

Summary: Membrane-active molecules are a promising strategy to target and kill pathogenic bacteria. This study tested a library of lipid-like compounds against Gram-negative bacteria to understand the structure-activity relationships and mechanisms of antimicrobial activity. The results showed that specific structural features, including hydrophobicity and charge density, play a crucial role in the antibacterial activity.

ANTIBIOTICS-BASEL (2023)

Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

Article Biotechnology & Applied Microbiology

Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria

Nermina Malanovic et al.

Summary: OCT is a well-established antiseptic molecule that is increasingly important for effective infection prevention and therapy due to the spread of antimicrobial resistance. Our study reveals the unspecific mechanism of action of OCT, which contributes to its broad antimicrobial profile and makes development of bacterial resistance less likely.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2022)

Article Biochemistry & Molecular Biology

Membrane Activity of LL-37 Derived Antimicrobial Peptides against Enterococcus hirae: Superiority of SAAP-148 over OP-145

Paulina Piller et al.

Summary: The development of antimicrobial agents against multidrug-resistant bacteria is crucial in the medical field. This study found that SAAP-148, an antimicrobial peptide, showed higher efficiency in killing bacteria and had stronger effects on membranes at both cellular and molecular levels compared to OP-145.

BIOMOLECULES (2022)

Article Biophysics

Distribution of cholesterol in asymmetric membranes driven by composition and differential stress

Malavika Varma et al.

Summary: The asymmetric lipid membranes of eukaryotic cells help to maintain stability, with cholesterol distribution between leaflets determined by chemical equilibrium. By controlling cholesterol mixing, it is possible to counteract biases in phospholipid numbers and regulate stress in the membrane under asymmetric conditions.

BIOPHYSICAL JOURNAL (2022)

Review Chemistry, Medicinal

Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Mallikarjuna N. Nadagouda et al.

Summary: Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that have gained much attention in research. They have various applications such as disinfectants, inhibitors of biofilm growth, and antibacterials.

MEDICINAL CHEMISTRY RESEARCH (2022)

Article Multidisciplinary Sciences

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

Rhythm Shukla et al.

Summary: The mechanism of action of Teixobactin has been revealed, showing that it damages bacterial cell membranes by binding to lipid II. This unique mode of action allows Teixobactin to target bacteria without harming human cells, making it a highly effective antibiotic.

NATURE (2022)

Article Biology

Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

Enrico F. Semeraro et al.

Summary: This study investigated the real-time response of Escherichia coli to lactoferricin-derived antimicrobial peptides (AMPs) using millisecond time-resolved synchrotron small-angle X-ray scattering. The results showed that the AMPs quickly permeabilize the cytosolic membrane, blocking important physiological processes and causing bacterial death. Additionally, even at sublethal peptide concentrations, damage and leakage of the cell envelope were observed. The most efficient AMP studied outperformed others in terms of membrane permeabilization speed and the lowest intracellular peptide concentration required to inhibit bacterial growth.

ELIFE (2022)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Review Chemistry, Multidisciplinary

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Bee Ha Gan et al.

Summary: Bacterial infections caused by 'superbugs' are on the rise globally, with traditional antibiotics becoming less effective, posing a risk of entering a post-antibiotic era. Antimicrobial peptides (AMPs) have garnered attention for their clinical potential as a new class of antibiotics to combat antimicrobial resistance. This review discusses various aspects of AMPs, including their physicochemical properties, mechanisms of action, and chemical synthesis strategies for developing novel AMPs.

CHEMICAL SOCIETY REVIEWS (2021)

Article Engineering, Biomedical

Bridging the Antimicrobial Activity of Two Lactoferricin Derivatives in E. coli and Lipid-Only Membranes

Lisa Marx et al.

Summary: The study showed that LF11-215 and LF11-324 can effectively target inner bacterial components and impact bacterial membranes. Both peptides exhibited comparable membrane binding in mimics containing different phospholipids, while also demonstrating concentration-dependent dye leakage activity.

FRONTIERS IN MEDICAL TECHNOLOGY (2021)

Review Chemistry, Physical

Structure-activity relationship of cationic surfactants as antimicrobial agents

Chengcheng Zhou et al.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2020)

Review Biotechnology & Applied Microbiology

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Nanoscience & Nanotechnology

Gemini Peptide Amphiphiles with Broad-Spectrum Antimicrobial Activity and Potent Antibiofilm Capacity

Ruilian Qi et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Multidisciplinary Sciences

The architecture of the Gram-positive bacterial cell wall

L. Pasquina-Lemonche et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

J. H. Lorent et al.

NATURE CHEMICAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Experimental concepts for linking the biological activities of antimicrobial peptides to their molecular modes of action

Nermina Malanovic et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Article Chemistry, Multidisciplinary

Protonation-Driven Aqueous Lyotropic Self-Assembly of Synthetic Six-Tail Lipidoids

James Jennings et al.

LANGMUIR (2020)

Article Cell Biology

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

Anna de Breij et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Neurosciences

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

Jianguo Li et al.

FRONTIERS IN NEUROSCIENCE (2017)

Article Nanoscience & Nanotechnology

Selective Antimicrobial Activities and Action Mechanism of Micelles Self-Assembled by Cationic Oligomeric Surfactants

Chengcheng Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Nanoscience & Nanotechnology

Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes

Chengcheng Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Article Chemistry, Medicinal

Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus

Megan C. Jennings et al.

ACS INFECTIOUS DISEASES (2015)

Review Biotechnology & Applied Microbiology

Quaternary Ammonium Biocides: Efficacy in Application

Charles P. Gerba

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

Article Chemistry, Medicinal

TMEDA-derived biscationic amphiphiles: An economical preparation of potent antibacterial agents

Jacob W. Black et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Chemistry, Physical

Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions

Xavier Mulet et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2013)

Article Biochemical Research Methods

Combinatorial Library of Lipidoids for In Vitro DNA Delivery

Shuo Sun et al.

BIOCONJUGATE CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix

Cecilia Leal et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The Importance of Interfacial Activity

Ramesh Rathinakumar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Chemistry, Multidisciplinary

Biomolecular engineering by combinatorial design and high-throughput screening: Small, soluble peptides that permeabilize membranes

Ramesh Rathinakumar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Biotechnology & Applied Microbiology

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc et al.

NATURE BIOTECHNOLOGY (2008)

Article Multidisciplinary Sciences

Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

Lihua Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

An intracellular lamellar-nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents

Rumiana Koynova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biotechnology & Applied Microbiology

Cationic antiseptics: diversity of action under a common epithet

P Gilbert et al.

JOURNAL OF APPLIED MICROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion

AB Schromm et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)