Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 7, Pages 1244-1247Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08702j
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- National Science Foundation
- Air Force Office of Scientific Research
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Dynamics of metabolon formation in mitochondria was probed by studying diffusional motion of two sequential Krebs cycle enzymes in a microfluidic channel. Enhanced directional co-diffusion of both enzymes against a substrate concentration gradient was observed in the presence of intermediate generation. This reveals a metabolite directed compartmentation of metabolic pathways.
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