4.7 Article

DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 30, Pages 6552-6555

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01003a

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Funding

  1. National Natural Science Foundation of China [21405038, 21135001, 21305036]
  2. Foundation for Innovative Research Groups of NSFC [21221003]
  3. 973'' National Key Basic Research Program [2011CB91100-0]
  4. Fundamental Research Funds for the Central Universities

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In this communication, we find that the single-walled carbon nanotubes (SWNTs) can demonstrate an excellent ssDNA concentration-dependent surface enhanced Raman scattering (SERS) effect after the decoration of DNA-templated in situ grown AgNPs on the surface. Inspired by this, the SWNT@AgNPs hybrid nanocomposite was employed to achieve microRNA detection which is also sensitive to crude extraction from human breast cancer cells and even patient tissues before and after chemotherapy.

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